Non-HDL-Cholesterin

2020 ◽  
Vol 18 (06) ◽  
pp. 242-246
Author(s):  
Leonie Adam ◽  
Thomas Bobbert
Keyword(s):  
Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Intermediate Density Lipoprotein ◽  
Intermediate Density ◽  
Niedriges Hdl ◽  
Ldl Cholesterin

ZUSAMMENFASSUNGDie diabetische Stoffwechsellage korreliert häufig mit einer Dyslipidämie, die sich typischerweise durch erhöhte Triglyzeride, niedriges HDL-Cholesterin und eine hohe Konzentration an small dense LDL-Cholesterin (LDL: low-density lipoprotein) auszeichnet. Zur kardiovaskulären Risikostratifizierung bei Diabetes mellitus Typ 2 eignet sich die Verwendung von Non-HDL-Cholesterin (HDL: high-density lipoprotein), um sämtliche potenziell atherogene Lipoproteine – VLDL (very-low-density lipoprotein), IDL (intermediate-density lipoprotein), LDL, Lipoprotein(a), Chylomikronen, Remnants – zu erfassen.

The Passage of Apoproteins from Plasma Lipoproteins into the Lipoproteins of Peripheral Lymph in Man

1977 ◽  
Vol 53 (3) ◽  
pp. 221-226
Author(s):  
D. Reichl ◽  
N. B. Myant ◽  
J. J. Pflug ◽  
D. N. Rudra
Keyword(s):  
Intravenous Injection ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Lipoproteins ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Intermediate Density Lipoprotein ◽  
Peripheral Lymph ◽  
Apoprotein B ◽  
Intermediate Density

1. The transport of apoprotein B from the lipoproteins of plasma into the lipoproteins of lymph draining the foot has been studied in four men with type III hyperlipoproteinaemia. 2. Three subjects were given autologous 125I-labelled very-low-density lipoprotein (VLDL) and 131I-labelled low-density lipoprotein (LDL) by intravenous injection; the fourth was given autologous 125I-labelled VLDL and 131I-labelled intermediate-density lipoprotein (IDL) plus LDL. 3. The 125I/131I ratios in serum and lymph apoprotein B, and the 125I and 131I specific radioactivities of apoprotein B in VLDL, IDL and LDL from serum and lymph, indicate that apoprotein B in the circulating VLDL can reach peripheral lymph without the intermediacy of circulating LDL.

scholarly journals HUBUNGAN LINGKAR PINGGANG DENGAN PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Mentari Simbar ◽  
Karel Pandelaki ◽  
M. C.P Wongkar
Keyword(s):  
Diabetes Mellitus ◽  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Cross Sectional ◽  
Diabetes Melitus

Abstract: Waist circumference is often used to evaluate abdominal fat mass. Waist circumference is correlated with abdominal mass and is a predictor of type 2 diabetes mellitus compared to BMI. Diabetes Mellitus Type 2 (T2DM) is more common in individuals with overweight and obesity. T2DM is not only occured due to carbohydrate metabolism disorder of lipid metabolism but also due to dyslipidemia. Dyslipidemia caused by substances called lipoprotein VLDL (Very Low Density Lipoprotein) or triglycerides, decreased HDL cholesterol (High Density Lipoprotein) and the formation of small dense LDL (Low Density Lipoprotein) which are atherogenic. This study aimed to determine the relationship of waist circumference with the lipid profile in T2DM patients Prof. R.D. Kandou Hospital Manado. This was a descriptive cross sectional analytic study. There were 53 respondents that met the inclusion criteria. This study was conducted for three months starting from September – November 2013 in the Endocrine Clinic. Conclusions: There was no significant correlation between waist circumference and total cholesterol, LDL, and triglycerides levels. However, there is a significant correlation between waist circumference and HDL levels.Keywords: Waist circumference, total cholesterol, HDL, LDL, Triglycerides, T2DMAbstrak: Lingkar pinggang sering digunakan sebagai penilai massa lemak abdominal, karena lingkar pinggang berkorelasi dengan massa lemak abdominal dan merupakan prediktor Diabetes Melitus Tipe 2 (DMT2) yang paling kuat dibandingkan dengan IMT. DMT2 lebih sering terjadi pada individu dengan berat badan lebih dan obesitas. Pada DMT2 bukan saja terjadi gangguan metabolisme karbohidrat melainkan juga terdapat metabolisme lipid, keadaan ini disebut dislipidemia. Dislipidemia terjadi akibat gangguan metabolisme lipoprotein yaitu Very Low Density Lipoprotein (VLDL), trigliserida, penurunan kolesterol High Density Lipoprotein (HDL), dan terbentuknya small dense Low Density Lipoprotein (LDL) yang bersifat aterogenik. Penelitian ini bertujuan untuk mengetahui hubungan lingkar pinggang dengan profil lipid pada pasien DMT2 di RSUP Prof. R.D. Kandou Manado. Jenis penelitian ini ialah deskriptif analitik dengan pendekatan cross sectional. Responden penelitian sebanyak 53 pasien yang memenuhi kriteria inklusi. Penelitian ini dilakukan selama tiga bulan yaitu dari bulan September – November 2013 di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. R.D. Kandou Manado. Simpulan: Tidak terdapat hubungan yang bermakna antara lingkar pinggang dengan kadar kolesterol total, kadar LDL, dan trigliserida. Terdapat hubungan bermakna antara lingkar pinggang dan kadar HDL.Kata kunci: Lingkar Pinggang, Kolesterol Total, HDL, LDL, Trigliserida, DMT2

The Composition of Low-Density Lipoprotein and Very-Low-Density Lipoprotein Subfractions in Primary Hypothyroidism and the Effect of Hormone-Replacement Therapy

1979 ◽  
Vol 57 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Fiona C. Ballantyne ◽  
A. A. Epenetos ◽  
Muriel Caslake ◽  
S. Forsythe ◽  
D. Ballantyne
Keyword(s):  
Ldl Cholesterol ◽  
Statistical Significance ◽  
Hormone Replacement ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Primary Hypothyroidism ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Intermediate Density Lipoprotein ◽  
Intermediate Density

1. The lipid and protein composition of subfractions of plasma low-density lipoprotein (LDL) has been determined in nine patients with primary hypothyroidism before and after 3 months of thyroxine therapy. Analyses were also made of subfractions of very-low-density lipoprotein (VLDL) in four of the patients. 2. Before therapy seven of the patients had elevated LDL-cholesterol and two had increased VLDL-cholesterol concentrations. On thyroxine replacement the mean LDL-cholesterol fell to normal. No significant change occurred in the concentration of cholesterol in VLDL or in high-density lipoprotein (HDL). 3. The concentrations of cholesterol, triglyceride and apolipoprotein B (apoB) were increased in the LDL subfraction of Sf 10·4–20, which corresponds mainly to intermediate-density lipoprotein. This subfraction showed a marked fall on therapy. The cholesterol and apoB concentrations in the major LDL fraction of Sf 5·7–12 also decreased on therapy, but the fall in the subfraction of Sf 3·5–6·5 did not reach statistical significance. 4. Only the VLDL subfraction of smallest size (Sf 20–60) had any abnormality before therapy, with an increased concentration of cholesterol. On thyroxine the concentration of triglyceride rose in the VLDL subfractions. 5. These data suggest that thyroxine exerts its major effect on lipoprotein metabolism by promoting the conversion into LDL of intermediate-density lipoprotein, formed by catabolism of VLDL.

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