Bilateral femoral capital physeal fractures in an adult cat with suspected congenital primary hypothyroidism

2019 ◽  
Vol 47 (01) ◽  
pp. 48-54
Author(s):  
Marius Diehm ◽  
Ricarda Dening ◽  
Peter Dziallas ◽  
Peter Wohlsein ◽  
Marion Schmicke ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Mild Hypothermia ◽  
Primary Hypothyroidism ◽  
Hair Coat ◽  
Presumptive Diagnosis ◽  
Total Thyroxine ◽  
Thyroid Stimulation Hormone ◽  
Adult Cat ◽  
Physical Findings ◽  
Physeal Fractures

AbstractA 4-year-old, neutered male European shorthair was presented for evaluation of right hind limb lameness. Radiographs revealed bilateral femoral capital physeal fractures, widened vertebral growth plates and constipation. Physical findings included lethargy, mental dullness, mild hypothermia, retarded growth, pharyngeal stridor, moderate muscle atrophy of pelvic limbs, hair coat abnormalities, and lack of defecation and urination. A thyroid panel revealed thyroid hormone values below detection limits and high thyroid stimulation hormone values. A presumptive diagnosis of congenital primary hypothyroidism was made, however also an early onset acquired primary hypothyroidism could not be ruled out. Results of the insulin-like growth factor (IGF-1) and the parathyroid hormone as well as an adrenocorticotropic hormone stimulating test were normal. A bilateral femoral head and neck excision was performed. Levothyroxine supplementation was started at a dosage of 50 µg (11 µg/kg) BID and later adjusted to 100 µg (22 µg/kg) BID based on total thyroxine concentrations. The tomcat showed full clinical recovery and normal clinical behaviour. The case shows that primary hypothyroidism may be considered in cats presented with femoral capital physeal fractures.

DISORDERS OF GLYCOGEN METABOLISM

PEDIATRICS ◽  
1952 ◽  
Vol 9 (3) ◽  
pp. 263-279
Author(s):  
WILLIAM H. LANGEWISCH ◽  
JOHN A. BIGLER
Keyword(s):  
Glycogen Storage Disease ◽  
Adrenocorticotropic Hormone ◽  
Storage Disease ◽  
Glycogen Metabolism ◽  
Glycogen Storage ◽  
Laboratory Evidence ◽  
Physical Findings ◽  
Treatment Prognosis

Five cases have been presented with evidence of disordered glycogen metabolism. Two cases of glycogen storage disease of the liver are included which were confirmed by biopsy, together with clinical and laboratory evidence. Treatment of one of the cases with adrenocorticotropic hormone resulted in a disappearance of hypoglycemia and acetonuria during the period of therapy. Two cases of glycogen storage disease of the heart are reported together with clinical histories and necropsy reports. An ECG which was recorded on one of the patients is included. A case of galactosemia is reported together with extensive laboratory evidence of marked galactose intolerance. The criteria for the diagnosis of these entities are reviewed and the symptomatology, physical findings, treatment, prognosis and pathologic manifestations are discussed.

scholarly journals Isolated growth hormone deficiency in a Chihuahua with a GH1 mutation

2020 ◽  
Vol 32 (5) ◽  
pp. 733-736
Author(s):  
Aki Iio ◽  
Shingo Maeda ◽  
Tomohiro Yonezawa ◽  
Yasuyuki Momoi ◽  
Tomoki Motegi
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Point Mutations ◽  
Reference Intervals ◽  
Hormone Deficiency ◽  
Deciduous Teeth ◽  
Hair Coat ◽  
Elevated Alkaline Phosphatase ◽  
Baseline Cortisol ◽  
Total Thyroxine

A 6-mo-old female Chihuahua was presented with recurrent episodes of hypoglycemia and collapse. Physical examination revealed proportionate dwarfism, retained puppy hair coat, retained deciduous teeth, and open fontanelles. Routine blood tests revealed hypoglycemia, thrombocytosis, hypoproteinemia, and elevated alkaline phosphatase activity. The urinalysis, radiographs, and ultrasonographs were unremarkable. Endocrine testing revealed that insulin-like growth factor 1 was below the detection limit; concentrations of total thyroxine, baseline cortisol, and cortisol stimulated by tetracosactide acetate were within their reference intervals. The pituitary gland showed no organic abnormalities on magnetic resonance imaging. For definitive diagnosis, we conducted the stimulation test for growth hormone (GH) release and diagnosed isolated GH deficiency. Genetic investigation revealed that the present case had 4 point mutations in intronic regions and a 6-bp deletion in exon 5 of GH1. The bioinformatics tool PROVEAN algorithm predicted that the deletion in exon 5 could be deleterious to the function of GH1.

scholarly journals Combined atypical primary hypoadrenocorticism and primary hypothyroidism in a dog

2016 ◽  
Vol 85 (6) ◽  
pp. 355-364
Author(s):  
B. Vanmal ◽  
V. Martlé ◽  
D. Binst ◽  
P. Smets ◽  
S. Daminet ◽  
...  
Keyword(s):  
Complete Resolution ◽  
Low Dose ◽  
Primary Hypothyroidism ◽  
Abdominal Ultrasonography ◽  
Maintenance Rate ◽  
Blood Examination ◽  
Total Thyroxine ◽  
One Year ◽  
Schmidt’S Syndrome

A dog with combined atypical primary hypoadrenocorticism and primary hypothyroidism is described. The dog presented with waxing and waning, vague complaints since more than a year and had been treated with several drugs without complete resolution of signs. Based on the abnormalities on physical examination, blood examination and abdominal ultrasonography, atypical primary hypoadrenocorticism and primary hypothyroidism were diagnosed. Glucocorticoid supplementation was started and gradually tapered to maintenance rate because of polydipsia. Ten days later, levothyroxine supplementation was started at a very low dose and was gradually increased based on serum total thyroxine concentrations. The dog rapidly improved and recovered completely. Follow-up over a one-year period did not reveal new abnormalities. The presence of combined primary hypoadrenocorticism and primary hypothyroidism has been infrequently described in dogs and may resemble the Schmidt’s syndrome in humans.

scholarly journals Congenital hypothyroidism and concurrent renal insufficiency in a kitten

2014 ◽  
Vol 85 (1) ◽  
Author(s):  
Chee Kin Lim ◽  
Chantal T. Rosa ◽  
Yolanda De Witt ◽  
Johan P. Schoeman
Keyword(s):  
Renal Insufficiency ◽  
Early Recognition ◽  
Clinical Signs ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Long Bones ◽  
Developmental Abnormality ◽  
Short Hair ◽  
Total Thyroxine ◽  
Low Serum

A 3-month-old male domestic short-hair kitten was presented with chronic constipation and disproportionate dwarfism. Radiographs of the long bones and spine revealed delayed epiphyseal ossification and epiphyseal dysgenesis. Diagnosis of congenital primary hypothyroidism was confirmed by low serum total thyroxine and high thyroid stimulating hormone concentrations. Appropriate supplementation of levothyroxine was instituted. The kitten subsequently developed mild renal azotaemia and renal proteinuria, possibly as a consequence of treatment or an unmasked congenital renal developmental abnormality. Early recognition, diagnosis and treatment are vital as alleviation of clinical signs may depend on the cat’s age at the time of diagnosis.

scholarly journals Primary Hypothyroidism and Thyroid Goiter in an Adult Cat

2014 ◽  
Vol 28 (2) ◽  
pp. 682-686 ◽  
Author(s):  
M. Galgano ◽  
I. Spalla ◽  
C. Callegari ◽  
M. Patruno ◽  
E. Auriemma ◽  
...  
Keyword(s):  
Primary Hypothyroidism ◽  
Thyroid Goiter ◽  
Adult Cat

PRIMARY HYPOTHYROIDISM WITH GROSSLY ELEVATED PLASMA TOTAL THYROXINE AND TRIIODOTHYRONINE LEVELS

1983 ◽  
Vol 19 (3) ◽  
pp. 295-303 ◽  
Author(s):  
G. J. BECKETT ◽  
J. A. TODD ◽  
G. J. HUGHES ◽  
I. W. CAMPBELL
Keyword(s):  
Primary Hypothyroidism ◽  
Elevated Plasma ◽  
Total Thyroxine

A Study of Thyroid Function in Psychiatric In-patients

1978 ◽  
Vol 133 (3) ◽  
pp. 211-218 ◽  
Author(s):  
D. G. McLarty ◽  
W. A. Ratcliffe ◽  
J. G. Ratcliffe ◽  
J. G. Shimmins ◽  
A. Goldberg
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Age Distribution ◽  
Psychiatric Hospitals ◽  
Primary Hypothyroidism ◽  
Hormone Levels ◽  
Total Thyroxine ◽  
Thyroid Hormone Levels

SummaryThe prevalence of abnormal serum total thyroxine (T4) and triiodothyronine (T3) concentrations were determined in 1,206 in-patients in two associated psychiatric hospitals. The biochemical pattern of primary hypothyroidism occurred in five females and one male (prevalence 0.5 per cent), but in only one patient was the diagnosis clinically obvious. Eight patients (all female) were clinically hyperthyroid (prevalence 0.7 per cent), of whom six were previously undiagnosed. There was no evidence that phenothiazines or benzodiazepine therapy had any significant effect on thyroid hormone levels. The small differences in thyroid hormone levels between psychiatric diagnostic groups could be explained by differences in age distribution.

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