The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic–ischemic brain in young mice

2002 ◽  
Vol 67 (6) ◽  
pp. 429-433 ◽  
Author(s):  
M. Akisu ◽  
A. Huseyinov ◽  
M. Baka ◽  
M. Yalaz ◽  
N. Kultursay
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Platelet Activating Factor ◽  
Dietary Supplementation ◽  
Leukotriene B4 ◽  
Ischemic Brain ◽  
Young Mice

Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model

2009 ◽  
Vol 247 (8) ◽  
pp. 1039-1050 ◽  
Author(s):  
Sabrina Viau ◽  
Marie-Annick Maire ◽  
Bruno Pasquis ◽  
Stéphane Grégoire ◽  
Niyazi Acar ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Dry Eye ◽  
Rat Model ◽  
Dietary Supplementation

scholarly journals Sexual maturity and fertility-related measures in young Nellore bulls receiving long-term dietary supplementation with rumen-protected polyunsaturated fatty acids

2019 ◽  
Vol 139 ◽  
pp. 16-27
Author(s):  
Guilherme Fazan Rossi ◽  
Erika Aline Ribeiro Dias ◽  
Natália Marins Bastos ◽  
Dayane Priscila Vrisman ◽  
Naiara Nantes Rodrigues ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Sexual Maturity ◽  
Dietary Supplementation

scholarly journals Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells

2008 ◽  
Vol 294 (5) ◽  
pp. G1181-G1190 ◽  
Author(s):  
Jing Lu ◽  
Michael S. Caplan ◽  
Dan Li ◽  
Tamas Jilling
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Intestinal Epithelial Cells ◽  
Platelet Activating Factor ◽  
Intestinal Epithelial ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Protein Palmitoylation ◽  
Induced Apoptosis ◽  
Phosphatidylinositol 3

We have shown earlier that platelet-activating factor (PAF) causes apoptosis in enterocytes via a mechanism that involves Bax translocation to mitochondria, followed by caspase activation and DNA fragmentation. Herein we report that, in rat small intestinal epithelial cells (IEC-6), these downstream apoptotic effects are mediated by a PAF-induced inhibition of the phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (Akt) signaling pathway. Treatment with PAF results in rapid dephosphorylation of Akt, phosphoinositide-dependent kinase-1, and the YXXM p85 binding motif of several proteins and redistribution of Akt-pleckstrin homology domain-green fluorescent protein, i.e., an in vivo phosphatidylinositol ( 3 , 4 , 5 )-trisphosphate sensor, from membrane to cytosol. The proapoptotic effects of PAF were inhibited by both n-3 and n-6 polyunsaturated fatty acids but not by a saturated fatty acid palmitate. Indomethacin, an inhibitor of prostaglandin biosynthesis, did not influence the baseline or PAF-induced apoptosis, but 2-bromopalmitate, an inhibitor of protein palmitoylation, inhibited all of the proapoptotic effects of PAF. Our data strongly suggest that an inhibition of the PI 3-kinase/Akt signaling pathway is the main mechanism of PAF-induced apoptosis in enterocytes and that polyunsaturated fatty acids block this mechanism very early in the signaling cascade independently of any effect on prostaglandin synthesis, and probably directly via an effect on protein palmitoylation.

scholarly journals Dietary Supplementation with n-3 Polyunsaturated Fatty Acids Reduces Torpor Use in a Tropical Daily Heterotherm

2016 ◽  
Vol 89 (6) ◽  
pp. 536-545 ◽  
Author(s):  
Pauline Vuarin ◽  
Pierre-Yves Henry ◽  
Martine Perret ◽  
Fabien Pifferi
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Supplementation
Sign in / Sign up

Export Citation Format

Share Document