Low-dose desmopressin infusion: renal action in healthy women in moderate salt retention and depletion, and interactions with prostanoids

2002 ◽  
Vol 67 (4) ◽  
pp. 263-273 ◽  
Author(s):  
G.C. Agnoli ◽  
R. Borgatti ◽  
M. Cacciari ◽  
P. Lenzi ◽  
M. Marinelli ◽  
...  
Keyword(s):  
Low Dose ◽  
Healthy Women ◽  
Renal Action

Elevated Plasma Fibrinogen and Increased Fibrin Turnover among Healthy Women who both Smoke and Use Low-dose Oral Contraceptives

1999 ◽  
Vol 82 (09) ◽  
pp. 1112-1116 ◽  
Author(s):  
Anne-Marie Vissac ◽  
Jean-Michel Kirzin ◽  
Pierre Bourgeat ◽  
Jean Amiral ◽  
Rachid Agher ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Low Dose ◽  
Factor Vii ◽  
Elevated Plasma ◽  
Thrombotic Risk ◽  
Mean Values ◽  
Healthy Women ◽  
Dose Oral ◽  
Fibrinolytic Capacity ◽  
D Dimer

SummaryAmong users of low-dose oral contraceptives (OC), cardiovascular diseases occur mainly in smokers. The mechanisms by which OC and smoking increase the risk for arterial thrombotic risk have not been adequately explained. Epidemiological evidence suggests that changes in blood coagulation and fibrinolysis may play an important role as determinants of thrombotic events. Therefore, we have investigated the associations of OC and smoking with haemostatic variables among 194 premenopausal healthy women. Fourty women were current users of low-dose OC and 62 women were smokers. After adjustment for age and body mass index, mean values of factor XIIa, factor VII activity and antigen, fibrinogen, D-dimer, global fibrinolytic capacity were significantly higher in OC users than in non-users. Mean levels of PAI activity and t-PA antigen were significantly lower in OC users than in non-users. Smokers had significantly higher mean values of fibrinogen than non-smokers. Two-way analysis of variance showed that the differences in mean levels of fibrinogen and D-dimer between OC users and non users were restricted to smokers. The positive and significant interactions between OC use and smoking in their effects on haemostatic variables were consistent with respect to age and type of OC. These preliminary data suggest that elevated plasma levels of fibrinogen and intravascular fibrin deposition may play a role in the pathogenesis of arterial thrombotic disease among women who are both low-dose OC users and smokers.

Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women

2001 ◽  
Vol 69 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Bernardo Bonanni ◽  
Harriet Johansson ◽  
Sara Gandini ◽  
Aliana Guerrieri-Gonzaga ◽  
Rosalba Torrisi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Low Dose ◽  
Insulin Like Growth Factor ◽  
Healthy Women ◽  
Factor System

Low-dose tamoxifen trial in healthy women

1997 ◽  
Vol 33 ◽  
pp. S10-S11
Author(s):  
B. Bonanni ◽  
A. Decensi ◽  
R. Travaglini ◽  
A. Guerrieri Gonazaga ◽  
A. Tessadrelli ◽  
...  
Keyword(s):  
Low Dose ◽  
Healthy Women

scholarly journals Spinal-Induced Hypotension in Preeclamptic and Healthy Parturients Undergoing Cesarean Section

2019 ◽  
Vol 7 (6) ◽  
pp. 996-1000 ◽  
Author(s):  
Atanas Sivevski ◽  
Emilija Ivanov ◽  
Dafina Кaradjova ◽  
Maja Slaninka-Miceska ◽  
Igor Kikerkov
Keyword(s):  
Cesarean Section ◽  
Incidence Rate ◽  
Spinal Anaesthesia ◽  
Low Dose ◽  
Induced Hypotension ◽  
Healthy Women ◽  
Severe Hypotension ◽  
Blood Pressures ◽  
Widespread Belief ◽  
Higher Doses

BACKGROUND: There is a widespread belief that spinal anaesthesia in patients with preeclampsia might cause severe hypotension and decreased uteroplacental perfusion. This study aimed to evaluate the incidence and severity of spinal induced-hypotension in preeclamptics and healthy parturients. METHODS: Total of 78 patients (40 healthy and 38 preeclamptic) undergoing a C-Section with spinal anaesthesia were included. Spinal anaesthesia was performed with a mixture of 8-9 mg isobaric 0.5% bupivacaine, 20 mcg fentanyl and 100 mcg morphine (total volume 2.2-2.4 ml). Blood pressures (BP)-SBP, DBP, MAP were recorded non-invasively before performing spinal anaesthesia and at 2.5 minutes after a spinal puncture. RESULTS: The BP falls (%) from baseline were significantly greater in the healthy parturients compared to those with preeclampsia (25.8% ± 10.1 vs 18.8% ± 17.0 for SBP, 28.5% ± 8.8 vs 22.5% ± 10.4 for DBP, and 31.2% ± 14.2 vs 18.2% ± 12.6% for MAP, p < 0.05). The incidence rate of hypotension in the preeclamptics was 25% compared to 53% in healthy parturients (p < 0.001). Higher doses of vasopressors both ephedrine (16.5 ± 8.6 vs 6.0 ± 2.0 mg) and phenylephrine (105 ± 25 mg) in the healthy women were required. There was no need for phenylephrine treatment in the preeclamptic group. CONCLUSION: This study showed that the incidence and severity of spinal-induced hypotension in preeclamptic patients are less than in healthy women. The use of low dose spinal anaesthesia also contributed to this statement.

The effects of a low-dose gestodene-containing oral contraceptive on endometrial histology in healthy women

1996 ◽  
Vol 1 (4) ◽  
pp. 325-329 ◽  
Author(s):  
C. M. H. Coenen ◽  
J. M. G. Hollanders ◽  
R. Rolland ◽  
D. Spielmann ◽  
J. Bulten
Keyword(s):  
Oral Contraceptive ◽  
Low Dose ◽  
Healthy Women

Low-dose progestin-releasing contraceptives are associated with a higher pain threshold in healthy women

2015 ◽  
Vol 104 (5) ◽  
pp. 1182-1189 ◽  
Author(s):  
Manuela Menezes Máximo ◽  
Patrícia Silveira Silva ◽  
Carolina Sales Vieira ◽  
Thaís Mangetti Gonçalvez ◽  
Júlio Cesar Rosa-e-Silva ◽  
...  
Keyword(s):  
Pain Threshold ◽  
Low Dose ◽  
Healthy Women

COAGULATION AND FIBRINOLYTIC STUDIES DURING CONTINUOUS USE OF LOW DOSE GESTAGEN

1970 ◽  
Vol 65 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Inga Marie Nilsson ◽  
Stig Kullander ◽  
Birger Åstedt
Keyword(s):  
Fibrinolytic Activity ◽  
Low Dose ◽  
Coagulation Factors ◽  
Fibrinolytic System ◽  
Histochemical Method ◽  
Venous Stasis ◽  
Chlormadinone Acetate ◽  
Healthy Women ◽  
Continuous Use ◽  
Apparently Healthy

ABSTRACT Coagulation factors and the fibrinolytic system were studied in 28 apparently healthy women using low dose gestagen continuously as a contraceptive (0.5 mg chlormadinone acetate daily). The fibrinolytic activity in the blood was also assessed after venous stasis. In 10 of the women determinations were also made of the content of activators of fibrinolysis in the walls of the veins by means of Todd's histochemical method. In contrast to what is seen after the use of contraceptive preparations of combined or sequential type, no changes were found in the factors studied. The increase in the fibrinolytic activity normally produced by venous stasis was not inhibited. The content of activators of fibrinolysis in the walls of the veins was unchanged.

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