Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet

2000 ◽  
Vol 62 (4) ◽  
pp. 253-259 ◽  
Author(s):  
M. Ali ◽  
K.K. Al-Qattan ◽  
F. Al-Enezi ◽  
R.M.A. Khanafer ◽  
T. Mustafa
Keyword(s):  
Blood Pressure ◽  
Serum Lipids ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Garlic Powder

scholarly journals Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet

2013 ◽  
Vol 12 (1) ◽  
pp. 138 ◽  
Author(s):  
Tamás Csont ◽  
Márta Sárközy ◽  
Gergő Szűcs ◽  
Csilla Szűcs ◽  
Judit Bárkányi ◽  
...  
Keyword(s):  
Infarct Size ◽  
Serum Lipids ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Multivitamin Preparation

Effects of low-dose ketanserin on atherosclerosis in rats and rabbits

2010 ◽  
Vol 88 (11) ◽  
pp. 1054-1060 ◽  
Author(s):  
Yong-Sheng Yu ◽  
He-Hui Xie ◽  
Ling Li ◽  
Shu-Wei Song ◽  
Ping Han ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
New Zealand ◽  
Treatment Group ◽  
Low Dose ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
New Zealand White Rabbits

The present study was designed to test the hypothesis that a small dose of ketanserin, which enhances baroreflex activity, prevents the early lesions of atherosclerosis. In experiment 1, baroreflex sensitivity (BRS) was measured in 31 spontaneously hypertensive rats (SHRs) in a conscious state using a computerized blood pressure monitoring system. Four weeks later, the rats were administered vitamin D3 and fed a high-cholesterol diet for 8 weeks to induce atherosclerosis. Then their hearts and aortae were removed for pathological examination. A negative correlation was found between BRS and the scores of coronary (r = –0.460, P < 0.01) and aortic atherosclerosis (r = –0.448, P < 0.05) in SHR. In experiment 2, SHRs were divided into 3 groups (n = 10 in each group) and received a dose of ketanserin of 0.3, 1.0, and 3.0 mg/kg (i.g.), respectively. At the smallest dose (0.3 mg/kg), ketanserin did not lower blood pressure but enhanced BRS. In experiment 3, SHRs were administered vitamin D3, fed a high-cholesterol diet, and simultaneously treated with low-dose ketanserin. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (coronary score: 0.90 ± 0.14 vs. 1.76 ± 0.27, P < 0.05; aortic scores: 1.00 ± 0.39 vs. 2.18 ± 0.41, P < 0.05). In experiment 4, male New Zealand White rabbits were fed a high-cholesterol diet and treated with low-dose ketanserin at the same time. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (aortic scores: 0.26 ± 0.20 vs. 0.60 ± 0.31, P < 0.05). In conclusion, the present study demonstrated, for the first time, that low-dose ketanserin prevented the development of atherosclerosis independent of its blood pressure lowering action in SHRs and New Zealand White rabbits at least in part via enhancement of arterial baroreflex function.

Suppression of Plasma Renin by Atherogenic Levels of Serum Cholesterol in Rabbits

1973 ◽  
Vol 45 (4) ◽  
pp. 565-569
Author(s):  
D. J. Campbell ◽  
S. L. Skinner ◽  
A. J. Day
Keyword(s):  
Blood Pressure ◽  
Serum Cholesterol ◽  
Enzyme Inhibitors ◽  
Kinetic Studies ◽  
Plasma Renin ◽  
Renin Secretion ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Renin Substrate

1. Sixteen rabbits received either a normal or a high cholesterol diet over an 80-day period. 2. Diastolic blood pressure remained unchanged in each group. 3. Progressive suppression of plasma renin activity and concentration without change in renin substrate occurred in animals receiving the high cholesterol diet. 4. Kinetic studies excluded the mediation of enzyme inhibitors in this response and made probable a true suppression of renin secretion. 5. Commonly recognized influences seemed not to account for the findings and the possibility is raised of a dependence of renin secretion upon serum cholesterol. The effect occurs at the level of serum cholesterol found in man.

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