Cell proliferation and tumour suppressor gene expression in iodine unstained area surrounding oral squamous cell carcinoma

2004 ◽  
Vol 33 (1) ◽  
pp. 75-83 ◽  
Author(s):  
K. Yokoo ◽  
H. Noma ◽  
T. Inoue ◽  
S. Hashimoto ◽  
M. Shimono
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

Downregulation of Tumour Suppressor Gene TSLC1 mRNA in Human Oral Squamous Cell Carcinoma

2009 ◽  
Vol 21 (3-4) ◽  
pp. 75-80
Author(s):  
Masayo Hayama ◽  
Katsuhiro Uzawa ◽  
Atsushi Kasamatsu ◽  
Morihiro Higo ◽  
Sufi Norhany ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

scholarly journals Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

2010 ◽  
Vol 52 (3) ◽  
pp. 417-424 ◽  
Author(s):  
Satiro Watanabe ◽  
Rogério Watanabe ◽  
Angélica F. Oton-Leite ◽  
Rita de C. G. Alencar ◽  
José C. Oliveira ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pattern Of Invasion

Bone Marrow Mesenchymal Stem Cells (BMSCs) with High Expression miR-155 Affect the Proliferation and Metastasis of Oral Squamous Cell Carcinoma by Regulating Phosphatase and Tensin Homolog 12 (PTEN12)

2021 ◽  
Vol 11 (8) ◽  
pp. 1571-1575
Author(s):  
Guowu Ma ◽  
Jia Hou ◽  
Jiezi Qiu ◽  
Jianlin Fan ◽  
Jianxin Yang
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Expression ◽  
Tensin Homolog ◽  
Proliferation And Metastasis ◽  
Apoptotic Activity ◽  
And Migration

Oral squamous cell carcinoma (OSCC) had the poor prognosis. miR-155 was involved in some diseases. However, whether BMSCs with high expression miR-155 affect the proliferation and metastasis of OSCC is unclear. Our study aims to assess BMSCs’ effect on OSCC cells. miR-155 level in OSCC tumor tissues was analyzed. BMSCs were transfected with miR-155 followed by analysis of cell proliferation by MTT assay, cell apoptosis and migration, and MMP-9 level by ELISA and PTEN12 level. In the tumor tissue, miR-155 level was significantly increased (P <0.05). Co-culture of BMSCs with high expression miR-155 with OSCC cells could significantly promote OSCC cell proliferation and reduced cell apoptotic activity, increased cell migration and MMP-9 secretion as well as downregualted PTEN12 expression (P <0.05). In conclusion, miR-155 was increased in the OSCC patients and BMSCs of high expression miR-155 could promote the proliferation and metastasis of OSCC by regulating PTEN12.

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