Doxorubicin and cyclophosphamide adjuvant chemotherapy is no more effective than cyclophosphamide, methotrexate, and 5-fluorouracil for premenopausal axillary lymph node positive breast cancer

2001 ◽  
Vol 2 (2) ◽  
pp. 83-86
Author(s):  
Dino Amadori
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Node Positive ◽  
Lymph Node Positive ◽  
Positive Breast Cancer

Prognostic Value of Histologic Grade and Proliferative Activity in Axillary Node–Positive Breast Cancer: Results From the Eastern Cooperative Oncology Group Companion Study, EST 4189

2000 ◽  
Vol 18 (10) ◽  
pp. 2059-2069 ◽  
Author(s):  
Jean F. Simpson ◽  
Robert Gray ◽  
Lynn G. Dressler ◽  
Charles D. Cobau ◽  
Carla I. Falkson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Mitotic Index ◽  
Axillary Lymph Node ◽  
Proliferative Activity ◽  
Eastern Cooperative Oncology Group ◽  
Axillary Lymph ◽  
Node Positive ◽  
Lymph Node Positive ◽  
Positive Breast Cancer

PURPOSE: The identification of a subset of patients with axillary lymph node–positive breast cancer with an improved prognosis would be clinically useful. We report the prognostic importance of histologic grading and proliferative activity in a cohort of patients with axillary lymph node–positive breast cancer and compare these parameters with other established prognostic factors. PATIENTS AND METHODS: This Eastern Cooperative Oncology Group laboratory companion study (E4189) centered on 560 axillary lymph node–positive patients registered onto one of six eligible clinical protocols. Flow cytometric (ploidy and S-phase fraction [SPF]) and histopathologic analyses (Nottingham Combined Histologic Grade and mitotic index) were performed on paraffin-embedded tissue from 368 patients. RESULTS: Disease recurred in 208 patients; in 161 (77%), within the first 5 years. Mitotic index and grade were associated with both ploidy and SPF (P ≤ .01). Within the first 5 years of follow-up, mitotic index (P = .004), grade (P = .004), ploidy (P = .006), and SPF (P = .05) were associated with time to recurrence; there was also a significant association with survival. The effect of mitotic index was largely a result of the difference between 0 to 2 mitoses/10 high-power fields (HPF; 5-year recurrence of 31%) and more than 2 mitoses/10 HPF (5-year recurrence of 52%). The 0 to 2 mitoses/10 HPF group was independently associated with improved prognosis at 5 years (P = .002) in regression models that included other standard prognostic factors. CONCLUSION: A subset of axillary lymph node–positive patients with improved prognosis may be identified using a lower (< 3 mitoses/10 HPF) mitotic count than is usually performed.

scholarly journals The Prognostic Significance of the Lymph Node Ratio in Axillary Lymph Node Positive Breast Cancer

2011 ◽  
Vol 14 (3) ◽  
pp. 204 ◽  
Author(s):  
Ji-Yoon Kim ◽  
Mi-Ryeong Ryu ◽  
Byung-Ock Choi ◽  
Woo-Chan Park ◽  
Se Jeong Oh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Axillary Lymph Node ◽  
Lymph Node Ratio ◽  
Prognostic Significance ◽  
Axillary Lymph ◽  
Node Positive ◽  
Node Ratio ◽  
Lymph Node Positive ◽  
Positive Breast Cancer
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