Anti-hypertensive treatment with calcium channel blockers has similar effects on mortality and cardiovascular event rates as diuretics and beta-blockers

2002 ◽  
Vol 6 (4) ◽  
pp. 156-157
Author(s):  
James M. Wright
Keyword(s):  
Calcium Channel ◽  
Cardiovascular Event ◽  
Calcium Channel Blockers ◽  
Beta Blockers ◽  
Channel Blockers ◽  
Event Rates

Cardiotoxicity with antihypertensive drugs (literature review) Part 1. Calcium channel blockers and beta-blockers

2021 ◽  
pp. 12-19
Author(s):  
A. N. Esaulenko ◽  
A. Yu. Moiseeva ◽  
A. A. Ivannikov ◽  
I. V. Bratischev ◽  
Kh. G. Alidzhanova
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Beta Blockers ◽  
Research Literature ◽  
Channel Blockers ◽  
Distinctive Features ◽  
Experimental Pharmacology ◽  
Myocardial Insufficiency ◽  
Β Blockers

The effect of hypotensive drugs overdose on cardiovascular system is poorly studied; it should undergo clinical, experimental pharmacology and toxicology together with cardiology. There is too little information about cardiotoxicity of beta-blockers (β-blockers) and calcium channel blockers (CCB) in existing research literature. Intoxication from these groups of drugs causes similar severe hemodynamic abnormalities and myocardial insufficiency, however pathophysiological mechanisms of these abnormalities are not thoroughly studied. The review highlights how difficult it is to identify toxic level and distinctive features of clinical evidence of intoxication. Methods of diagnosis as well as β-blockers and CCB overdose treatment are discussed.

Pre-fracture medication use as a predictor of 30-day mortality in hip fracture patients: an analysis of 141,201 patients

2019 ◽  
Vol 30 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Christopher Jantzen ◽  
Christian M Madsen ◽  
Bo Abrahamsen ◽  
Susanne Van Der Mark ◽  
Benn R Duus ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Ace Inhibitors ◽  
Beta Blockers ◽  
Channel Blockers ◽  
Prescription Database ◽  
Fracture Type ◽  
Co Morbidity ◽  
Morbidity Index

Purpose: To evaluate the predictive value of pre-fracture medication usage on 30-day mortality following a hip fracture. Methods: Information on age, sex, fracture type, time of death and Charlson co-morbidity index (CCI) was collected from the Danish National Patient Registry on all patients above 60 years, sustaining a hip fracture during the period January 1995 to December 2013. Information on drug usage was obtained from the Danish National Prescription Database. Hazard ratios were calculated with 30-day mortality as the outcome. A univariate and 3 multivariate analyses were conducted with increasing adjustments, starting with age, sex and fracture type, adding co-morbidity and dose in the latter. Results: 141,201 patients were included and a total of 12 drugs/drug groups were identified for analysis. Increased mortality was evident in all analyses for antiarrhythmics, beta blockers, proton pump inhibitors, loop diuretics, opioids, acetaminophen and for psycholeptics. For ACE-inhibitors, increased mortality was found in all analyses, except after adjustment for co-morbidity and dose. For thiazide diuretics, a significantly reduced mortality was evident in all but the univariate analyses while NSAIDs and statins were associated with a significantly reduced mortality in all analyses. For calcium channel blockers, an insignificant decrease was found after adjustment for dose. Further analysis showed a dose-response relationship for all drugs except ACE-inhibitors and calcium channel blockers. Conclusion: The study shows a correlation between pre-fracture usage of certain drugs and 30 day mortality after a hip fracture.

scholarly journals Atrial arrhythmias in chronic lung disease-associated pulmonary hypertension

2020 ◽  
Vol 10 (1) ◽  
pp. 204589402091068 ◽  
Author(s):  
Cyrus A. Vahdatpour ◽  
Jeffrey J. Luebbert ◽  
Harold I. Palevsky
Keyword(s):  
Pulmonary Hypertension ◽  
Respiratory Failure ◽  
Calcium Channel ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Calcium Channel Blockers ◽  
Beta Blockers ◽  
Cor Pulmonale ◽  
Channel Blockers ◽  
Atrial Arrhythmias

Atrial arrhythmias are common during episodes of acute respiratory failure in patients with chronic lung disease-associated pulmonary hypertension. Expert opinion suggests that management of atrial arrhythmias in patients with pulmonary hypertension should aim to restore sinus rhythm. This is clinically challenging in pulmonary hypertension patients with coexisting chronic lung disease, as there is controversy on the use of rhythm control agents; generally, in regard to either their pulmonary toxicity profile or the lack of evidence supporting their use. Rate control methods are largely focused on the use of beta blockers and calcium channel blockers. Concerns regarding their use involve their negative inotropic properties in cor pulmonale, the risk of bronchospasm associated with beta blockers, and the potential for ventilation/perfusion mismatching associated with calcium channel blockers. While digoxin has been associated with promising outcomes during acute right ventricular failure, there is limited evidence to suggest its routine use. Electrical cardioversion is associated with a high failure rate and it frequently requires multiple attempts. Radiofrequency catheter ablation is a more definitive approach, but concerns surrounding mechanical ventilation and sedation limit its applicability in decompensated pulmonary hypertension. Individual approaches are needed to address atrial arrhythmia management during acute episodes of respiratory failure.

scholarly journals Sequential comparison of therapy with beta-blockers and calcium channel blockers with celiprolol therapy in patients with angina pectoris, hypertension, or both

1996 ◽  
Vol 57 (8) ◽  
pp. 614-621
Author(s):  
Ton J.M. Cleophas ◽  
Menlo G. Niemeyer ◽  
Piet J.L.M. Bernink ◽  
Koos H. Zwinderman ◽  
Anton V. Wijk ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Beta Blockers ◽  
Channel Blockers ◽  
Sequential Comparison
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