Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality

2003 ◽  
Vol 22 (1) ◽  
pp. 23-30 ◽  
Author(s):  
R NIJVELDT
Keyword(s):  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
High Plasma ◽  
Icu Mortality ◽  
Asymmetrical Dimethylarginine ◽  
Plasma Adma ◽  
Adma Concentration

Depression as an Independent Risk Factor for Mortality in Critically Ill Patients

2015 ◽  
Vol 77 (2) ◽  
pp. 106-113 ◽  
Author(s):  
Marlene Wewalka ◽  
Joanna Warszawska ◽  
Volker Strunz ◽  
Reinhard Kitzberger ◽  
Ulrike Holzinger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor

scholarly journals Is Vitamin D Insufficiency Associated with Mortality of Critically Ill Patients?

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gulbin Aygencel ◽  
Melda Turkoglu ◽  
Ayse Fitnat Tuncel ◽  
Burcu Arslan Candır ◽  
Yelda Deligoz Bildacı ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Vitamin D Insufficiency ◽  
University Hospital ◽  
Median Serum ◽  
Vitamin D Levels ◽  
Sufficient Vitamin

Objective. To evaluate the vitamin D status of our critically ill patients and its relevance to mortality.Patients and Methods. We performed a prospective observational study in the medical intensive care unit of a university hospital between October 2009 and March 2011. Vitamin D levels were measured and insufficiency was defined as <20 ng/mL.Results. Two hundred and one patients were included in the study. The median age was 66 (56–77) and the majority of patients were male (56%). The median serum level of vitamin D was 14,9 ng/mL and 139 (69%) patients were vitamin D insufficient on admission. While we grouped the ICU patients as vitamin D insufficient and sufficient, vitamin D insufficient patients had more severe acute diseases and worse laboratory values on admission. These patients had more morbidities and were exposed to more invasive therapies during stay. The mortality rate was significantly higher in the vitamin D insufficient group compared to the vitamin D sufficient group (43% versus 26%,P=0,027). However, logistic regression analysis demonstrated that vitamin D insufficiency was not an independent risk factor for mortality.Conclusion. Vitamin D insufficiency is common in our critically ill patients (69%), but it is not an independent risk factor for mortality.

scholarly journals New-onset atrial fibrillation in critically ill patients with coronavirus disease 2019 (COVID-19)

2021 ◽  
Author(s):  
BİŞAR ERGÜN ◽  
BEGUM ERGAN ◽  
Melih Kaan SÖZMEN ◽  
Mehmet Nuri YAKAR ◽  
Murat KÜÇÜK ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Onset Atrial Fibrillation ◽  
New Onset

Abstract Objectives: To determine the incidence, risk factors, and outcomes of new-onset atrial fibrillation (NOAF) in a cohort of critically ill patients with coronavirus disease 2019 (COVID-19). Methods: We conducted a retrospective study on patients admitted to the intensive care unit (ICU) with a diagnosis of COVID-19. NOAF was defined as atrial fibrillation that was detected after diagnosis of COVID-19 without a prior history. The primary outcome of the study was the effect of NOAF on mortality in critically ill COVID-19 patients. Results: We enrolled 248 eligible patients. NOAF incidence was 14.9% (n=37), and 78% of patients (n=29) were men in NOAF positive group. Median age of the NOAF group was 79.0 (interquartile range, 71.5-84.0). Hospital mortality was higher in the NOAF group (87% vs 67%, respectively, p=0.019). However, in multivariate analysis, NOAF was not an independent risk factor for hospital mortality (OR 1.42, 95% CI 0.40–5.09, p=0.582) Conclusions: The incidence of NOAF was 14.9% in critically ill COVID-19 patients. Hospital mortality was higher in the NOAF group. However, NOAF was not an independent risk factor for hospital mortality in patients with COVID-19. Keywords: Atrial fibrillation, critical care, intensive care unit, COVID-19, mortality, hospital mortality

scholarly journals Renal replacement therapy is an independent risk factor for mortality in critically ill patients with acute kidney injury

Critical Care ◽  
2010 ◽  
Vol 14 (6) ◽  
pp. R221 ◽  
Author(s):  
Monique M Elseviers ◽  
Robert L Lins ◽  
Patricia Van der Niepen ◽  
Eric Hoste ◽  
Manu L Malbrain ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Kidney Injury

scholarly journals Hyperphosphatemia Is an Independent Risk Factor for Mortality in Critically Ill Patients: Results from a Cross-Sectional Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133426 ◽  
Author(s):  
Dominik G. Haider ◽  
Gregor Lindner ◽  
Michael Wolzt ◽  
Sufian S. Ahmad ◽  
Thomas Sauter ◽  
...  
Keyword(s):  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Pulmonary Hypertension an Independent Risk Factor for Death in Intensive Care Unit: Correlation of Hemodynamic Factors with Mortality

2015 ◽  
Vol 9 ◽  
pp. CCRPM.S22199 ◽  
Author(s):  
Ghulam Saydain ◽  
Aamir Awan ◽  
Palaniappan Manickam ◽  
Paul Kleinow ◽  
Safwan Badr
Keyword(s):  
Intensive Care Unit ◽  
Pulmonary Hypertension ◽  
Risk Factor ◽  
Intensive Care ◽  
Pulmonary Artery ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Independent Risk Factor ◽  
Apache Ii ◽  
Hemodynamic Parameters

Objective Critically ill patients with pulmonary hypertension (PH) pose additional challenges due to the existence of right ventricular (RV) dysfunction. The purpose of this study was to assess the impact of hemodynamic factors on the outcome. Methods We reviewed the records of patients with a diagnosis of PH admitted to the intensive care unit. In addition to evaluating traditional hemodynamic parameters, we defined severe PH as right atrial pressure >20 mmHg, mean pulmonary artery pressure >55 mmHg, or cardiac index (CI) <2 L/min/m2. We also defined the RV functional index (RFI) as pulmonary artery systolic pressure (PASP) adjusted for CI as PASP/CI; increasing values reflect RV dysfunction. Results Fifty-three patients (mean age 60 years, 72% women, 79% Blacks), were included in the study. Severe PH was present in 68% of patients who had higher Sequential Organ Failure Assessment (SOFA) score (6.8 ± 3.3 vs 3.8 ± 1.6; P = 0.001) and overall in-hospital mortality (36% vs 6%; P = 0.02) compared to nonsevere patients, although Acute Physiology and Chronic Health Evaluation (APACHE) II scores (19.9 ± 7.5 vs 18.5 ± 6.04; P = 0.52) were similar and sepsis was more frequent among nonsevere PH patients (31 vs 64%; P = 0.02). Severe PH ( P = 0.04), lower mean arterial pressure ( P = 0.04), and CI ( P = 0.01); need for invasive ventilation ( P = 0.02) and vasopressors ( P = 0.03); and higher SOFA ( P = 0.001), APACHE II ( P = 0.03), pulmonary vascular resistance index (PVRI) ( P = 0.01), and RFI ( P = 0.004) were associated with increased mortality. In a multivariate model, SOFA [OR = 1.45, 95% confidence interval (C.I.) = 1.09-1.93; P = 0.01], PVRI (OR = 1.12, 95% C.I. = 1.02-1.24; P = 0.02), and increasing RFI (OR = 1.06, 95% C.I. = 1.01-1.11; P = 0.01) were independently associated with mortality. Conclusion PH is an independent risk factor for mortality in critically ill patients. Composite factors rather than individual hemodynamic parameters are better predictors of outcome. Monitoring of RV function using composite hemodynamic factors resulting in specific interventions is likely to improve survival and needs to be studied further.

scholarly journals Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study

2021 ◽  
pp. 088506662110054
Author(s):  
Kevin Ho ◽  
Joshua Gordon ◽  
Kevin T. Litzenberg ◽  
Matthew C. Exline ◽  
Joshua A. Englert ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Respiratory Distress Syndrome ◽  
Cohort Study ◽  
Critically Ill ◽  
Retrospective Cohort Study ◽  
Critically Ill Patients ◽  
Retrospective Cohort ◽  
Independent Risk Factor ◽  
Distress Syndrome ◽  
Single Center

Background: Acute Respiratory Distress Syndrome (ARDS) is a frequent cause of respiratory failure in intensive care unit (ICU) patients and results in significant morbidity and mortality. ARDS often develops as a result of a local or systemic inflammatory insult. Cancer can lead to systemic inflammation but whether cancer is an independent risk factor for developing ARDS is unknown. We hypothesized that critically ill cancer patients admitted to the ICU were at increased risk for the diagnosis of ARDS. Methods: Retrospective cohort study of critically ill patients admitted between July 2017 and December 2018 at an academic medical center in Columbus, Ohio. The primary outcome was the association of patients with malignancy and the diagnosis of ARDS in a multivariable logistic regression model with covariables selected a priori informed through the construction of a directed acyclic graph. Results: 412 ARDS cases were identified with 166 of those patients having active cancer. There was an association between cancer and ARDS, with an odds ratio (OR) of 1.55 (95% CI 1.26-1.92, P < 0.001). When adjusted for our pre-specified confounding variables, the association remained statistically significant (OR 1.57, 95% CI 1.15-2.13, P = 0.004). In an unadjusted pre-specified subgroup analysis, hematologic malignancy (OR 1.81, 95% CI 1.30-2.53, P < 0.001) was associated with increased odds of developing ARDS while non-metastatic solid tumors (OR 0.51, 95% CI 0.31-0.85, P = 0.01) had statistically significant negative association. Cancer patients with ARDS had a significantly higher ICU (70.5% vs 39.8%, P < 0.001) and hospital (72.9% vs 40.7%, P < 0.001) mortality compared to ARDS patients without active malignancy. Conclusion: In this single center retrospective cohort study, cancer was found to be an independent risk factor for the diagnosis of ARDS in critically ill patients. To our knowledge, we are the first report an independent association between cancer and ARDS in critically ill patients.

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