scholarly journals Advanced-stage cervix cancer: rapid tumour growth rather than late diagnosis

2000 ◽  
Vol 83 (5) ◽  
pp. 566-568 ◽  
Author(s):  
P Symonds ◽  
B Bolger ◽  
D Hole ◽  
J H Mao ◽  
T Cooke
Keyword(s):  
Tumour Growth ◽  
Late Diagnosis ◽  
Cervix Cancer ◽  
Advanced Stage ◽  
Rapid Tumour

The Story of Annie Gratitude and Faith

2018 ◽  
Author(s):  
David Wendell Moller
Keyword(s):  
Healthcare System ◽  
Vulnerable Populations ◽  
Life Experiences ◽  
Negative Impact ◽  
Medical System ◽  
Late Diagnosis ◽  
Advanced Stage ◽  
Low Literacy ◽  
Great Divide

The narrative of Bill Wheeler expresses his sense of betrayal and neglect. There was a great divide between the life experiences of Mr. Wheeler and his caregivers. He was angry that his late diagnosis was related to being poor and uninsured. He resented that his doctors did not communicate with him effectively. He felt they misrepresented things, failed to listen attentively, and disregarded his suffering and needs. The decision to treat his cancer aggressively despite its advanced stage initially provided hopeful expectations but ultimately led to shattered hope, greater anger, and late enrollment in hospice. The result is that Mr. Wheeler went to his death feeling neglected and uncared for. The negative impact of poor communication is magnified due to inadequate resources, low literacy, and mistrust of the medical system. Emotional handling of patients in vulnerable populations is crucial because these patients often mistrust physicians and the healthcare system at large.

scholarly journals The natural history and treatment of non-functioning pituitary adenomas (non-functioning PitNETs)

2020 ◽  
Vol 27 (10) ◽  
pp. R375-R390
Author(s):  
Maria P Yavropoulou ◽  
Marina Tsoli ◽  
Konstantinos Barkas ◽  
Gregory Kaltsas ◽  
Ashley Grossman
Keyword(s):  
Active Surveillance ◽  
Medical Therapy ◽  
Pituitary Adenomas ◽  
Tumour Growth ◽  
Neuroendocrine Tumours ◽  
Early Recurrence ◽  
Initial Size ◽  
Rapid Tumour ◽  
Non Functioning Pituitary Adenomas

Non-functioning pituitary adenomas, recently alternatively termed pituitary neuroendocrine tumours (NFpitNETs), are mostly benign neoplasms that are not associated with a hormonal hypersecretory syndrome. The clinical spectrum of NFpitNETs varies from completely asymptomatic to the development of panhypopituitarism and manifestations attributed to mass effects on nearby structures. NFpitNETs follow generally an indolent course, but in 5–10% of cases they exhibit more aggressive behaviour, characterised by rapid growth, invasiveness and early recurrence. The initial size of the adenoma, the presence of symptoms and the histological subtype are related to the natural course of NFpitNETs. Active surveillance is usually the strategy of choice in the case of an asymptomatic NFpitNET, while surgical resection is recommended in case of visual and/or neurological abnormalities or rapid tumour growth. Based on previous and emerging data, approximately 50% of patients show tumour growth, while 20% of patients with NF-macroadenomas on active surveillance may require further intervention during a follow-up period of 7 years. Adjuvant radiotherapy is usually considered for large residual tumours or recurrent and/or aggressive adenomas, but there is evidence that medical therapy, especially with cabergoline, can occasionally be beneficial, whereas newer molecular agents are under investigation. Thus, while highly effective medical therapy is awaited, a move towards a more conservative approach seems appropriate, at least until we have better molecular markers of progressiveness.

Current and future therapeutic approaches in locally advanced (stage III) non[ndash ]small cell lung cancer

2002 ◽  
Vol 29 (3 Suppl 12) ◽  
pp. 10-16 ◽  
Author(s):  
Angela Davies ◽  
David R. Gandara ◽  
Primo Lara ◽  
Zelanna Goldberg ◽  
Peter Roberts ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Locally Advanced ◽  
Small Cell ◽  
Stage Iii ◽  
Advanced Stage ◽  
Therapeutic Approaches ◽  
Small Cell Lung
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