Future directions in the treatment of pancreatic cancer

2002 ◽  
Vol 29 (6U) ◽  
pp. 31-39 ◽  
Author(s):  
Daniel G. Haller
Keyword(s):  
Pancreatic Cancer ◽  
Future Directions

Terpenoids as Potential Targeted Therapeutics of Pancreatic Cancer: Current Advances and Future Directions

2019 ◽  
pp. 111-116 ◽  
Author(s):  
Rama Rao Malla ◽  
Seema Kumari ◽  
K.G.K. Deepak ◽  
Murali Mohan Gavara ◽  
Shailender Guganavath ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapeutics ◽  
Future Directions

scholarly journals MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 752 ◽  
Author(s):  
Rawat ◽  
Kadian ◽  
Gupta ◽  
Kumar ◽  
Chain ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Therapeutic Potential ◽  
Critical Role ◽  
Mirna Biogenesis ◽  
Effective Management ◽  
Future Directions ◽  
Novel Therapeutic Strategies ◽  
Conclusion Section

Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.

scholarly journals Neoadjuvant Therapy in Pancreatic Cancer: An Emerging Strategy

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Alessandro Bittoni ◽  
Matteo Santoni ◽  
Andrea Lanese ◽  
Chiara Pellei ◽  
Kalliopi Andrikou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Case Series ◽  
Tumour Response ◽  
Tumour Regression ◽  
Resectable Pancreatic Cancer ◽  
Borderline Resectable ◽  
Future Directions ◽  
Tumour Implantation

Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths among men and women, being responsible for 6% of all cancer-related deaths. Surgical resection offers the only chance of cure, but only 15 to 20 percent of cases are potentially resectable at presentation. In recent years, increasing evidences support the use of neoadjuvant strategies in pancreatic cancer in patients with resectable pancreatic cancer as well as in patients with borderline resectable or locally advanced PDAC in order to allow early treatment of micrometastatic disease, tumour regression, and reduced risk of peritoneal tumour implantation during surgery. Furthermore, neoadjuvant treatment allows evaluation of tumour response and increases patient’s compliance. However, most evidences in this setting come from retrospective analysis or small case series and in many studies chemotherapy or chemoradiation therapies used were suboptimal. Currently, prospective randomized trials using the most active chemotherapy regimens available are trying to define the real benefit of neoadjuvant strategies compared to conventional adjuvant strategies. In this review, the authors examined available data on neoadjuvant treatment in patients with resectable pancreatic cancer as well as in patients with borderline resectable or locally advanced PDAC and the future directions in this peculiar setting.

scholarly journals Surgery for pancreatic cancer: recent progress and future directions

2021 ◽  
Vol 10 (3) ◽  
pp. 376-378
Author(s):  
Zachary J. Brown ◽  
Jordan M. Cloyd
Keyword(s):  
Pancreatic Cancer ◽  
Recent Progress ◽  
Future Directions

scholarly journals Future directions in drug development in pancreatic cancer

2021 ◽  
Author(s):  
Aurélien Lambert ◽  
Thierry Conroy ◽  
Michel Ducreux
Keyword(s):  
Pancreatic Cancer ◽  
Drug Development ◽  
Future Directions

Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions

2016 ◽  
Vol 16 (5) ◽  
pp. 523-530 ◽  
Author(s):  
Sten Myrehaug ◽  
Arjun Sahgal ◽  
Suzanne M. Russo ◽  
Simon S. Lo ◽  
Lauren M. Rosati ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stereotactic Body Radiotherapy ◽  
Recent Progress ◽  
Future Directions

scholarly journals Position emission tomography imaging in pancreatic cancer: recent progress and future directions

2019 ◽  
Vol 2 ◽  
pp. 6-6
Author(s):  
Xiaoli Zhang ◽  
Xue Meng ◽  
Hui Zhu ◽  
Qiuan Yang ◽  
Katherine T. Morris ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Recent Progress ◽  
Emission Tomography ◽  
Position Emission Tomography ◽  
Future Directions ◽  
Tomography Imaging
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