Adsorption of natriuretic factors in uremia

2001 ◽  
Vol 21 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Martina Franz ◽  
Wolfgang Woloszczuk ◽  
Walter H. H[ouml ]rl
Keyword(s):  
Natriuretic Factors

Synthesis, Molecular Cloning and Expression of Genes Coding for Atrial Natriuretic Factors from Rat and Human

1988 ◽  
Vol 7 (1) ◽  
pp. 61-73 ◽  
Author(s):  
Hans Sachse ◽  
Gerd Hagendorff ◽  
Klaus Dieter Preuβ ◽  
Hari S. Sharma ◽  
Karl Heinz Scheit
Keyword(s):  
Molecular Cloning ◽  
Cloning And Expression ◽  
Expression Of Genes ◽  
Atrial Natriuretic Factors ◽  
Natriuretic Factors ◽  
Atrial Natriuretic

Atrial Natriuretic Factors and the Brain (Les facteurs natriurétiques auriculaires et le cerveau)

1988 ◽  
Vol 66 (3) ◽  
pp. 253-254 ◽  
Author(s):  
Rémi Quirion
Keyword(s):  
International Society ◽  
Natriuretic Peptides ◽  
Salt Intake ◽  
Atrial Natriuretic Peptides ◽  
Peripheral Tissues ◽  
The Brain ◽  
Biological Actions ◽  
Atrial Natriuretic Factors ◽  
Natriuretic Factors ◽  
Atrial Natriuretic

Canadian scientists have played a major role in the discovery and characterization of various atrial natriuretic factors (ANF). It is now clear that this family of polypeptides induces multiple biological actions in a broad variety of peripheral tissues including the kidney, adrenal gland, and blood vessels. One generalized observation derived from multiple studies reveals that these peptides most likely act as important modulators of homeostasis by modulating the production of various body fluids. Recently, it became clear that the atrial natriuretic factors present in the central nervous system could influence various brain functions. Thus, the ANF-like peptides should be considered as a new family of brain–heart peptides.The present symposium, the first of its kind, was organized to examine and critically discuss the evidence for putative roles of atrial natriuretic peptides in the brain. It was clearly demonstrated that atrial natriuretic peptide-like immunoreactivity is widely distributed in mammalian and nonmammalian brains with a high number of cell bodies and (or) fiber terminals present in areas associated with water and salt intake and with the control of cardiovascular parameters. The gene transcripts responsible for the production of brain atrial natriuretic polypeptides have been isolated and their characteristics appear to be similar to those found in peripheral tissues. The presence and plasticity of specific brain ANF receptor sites have also been reported. It appears that at least one population of sites is associated with the activation of guanylate cyclase and it was also shown that specific ANF receptors are located on brain microvessels and can modulate the permeability of the blood-brain barrier. Finally, it has been shown that atrial natriuretic polypeptides exert various biological actions in the brain including electrophysiological effects in the hypothalamus, modulation of water and salt intake, alteration of various cardiovascular parameters, and release of certain pituitary hormones.Interactions with dopaminergic pathways, vasopressin, and (or) angiotensin II systems could be associated with some biological effects of atrial natriuretic peptides in the brain. Naturally, much remains to be known on the exact physiological role of brain atrial natriuretic factors, but this meeting represents the first attempt towards the integration of the most recent findings in this exciting research area.This symposium was an official satellite of the first joint meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, held in Venezuela in May–June 1987. The success of the symposium has been ensured by generous donations from the International Society for Neurochemistry, the Medical Research Council of Canada, and various companies including Amersham International (England), ANAWA Trading SA (Switzerland), Ayerst Laboratories (U.S.A.), Bachem (Switzerland), Bayer AG (West Germany), Bio-Mega Inc. (Canada), Ciba-Geigy Corporation (U.S.A.), Dupont Canada – New England Nuclear Co. (Canada), Eli Lilly Research Laboratories (U.S.A.), Farmitalia Carlo Erba (Italy), Institut Henri Beaufour (France), Merck Sharp &Dohme Research Laboratories (U.S.A.), Miles Laboratories Inc. (U.S.A.), Monsanto Co. (U.S.A.), Novabiochem (Switzerland), Novopharm Ltd. (Canada), Peninsula Laboratories (U.S.A.), and the Peptide Institute and Protein Research Foundation (Japan).

Purification of three rat atrial natriuretic factors and their amino acid composition

FEBS Letters ◽  
1983 ◽  
Vol 164 (2) ◽  
pp. 286-290 ◽  
Author(s):  
G. Thibault ◽  
R. Garcia ◽  
N.G. Seidah ◽  
C. Lazure ◽  
M. Cantin ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Atrial Natriuretic Factors ◽  
Natriuretic Factors ◽  
Atrial Natriuretic

Effects of atrial natriuretic peptide, dopamine, and ouabain on aldosterone synthesis

1987 ◽  
Vol 115 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Sadao Nakajima ◽  
Hiromichi Suzuki ◽  
Ikuo Saito ◽  
Takao Saruta
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
In Vivo Study ◽  
Stimulatory Action ◽  
Related Substances ◽  
Natriuretic Factors ◽  
Atrial Natriuretic

Abstract. This study was undertaken to examine the effects of atrial natriuretic peptide (ANP), dopamine, and ouabain, which each are considered to be a kind of natriuretic factor, on aldosterone synthesis in vivo and in vitro. In the in vivo experiments, during infusion of one of the natriuretic factors, ANP (64 pmol · min−1 · kg−1), dopamine (20 nmol · min−1 · kg−1) or ouabain (684 pmol · min−1 · kg−1), the stimulatory action of angiotensin II (20 pmol · min−1 · kg−1) or adrenocorticotropin (ACTH, 7 pmol · min−1 · kg−1) on aldosterone synthesis was investigated in 36 anaesthetized (pentobarbital, 40 mg/kg, iv) female rabbits. In the basal condition, aldosterone synthesis was suppressed slightly by each of the natriuretic factors. The stimulatory actions of angiotensin II and ACTH on aldosterone synthesis were significantly attenuated by pre-treatment with ANP and dopamine. However, ouabain infusion did not induce any changes in the synthesis of aldosterone, 18-hydroxycorticosterone (18-OHB), and corticosterone (B) in either the basal or the stimulated conditions. For the in vitro experiments, rabbit adrenal glomerulosa cells (105 cells/tube) were used. The effects of ANP and dopamine on the aldosterone synthesis revealed results identical to those from the in vivo study. However, in contrast to the in vivo study, ouabain completely inhibited the synthesis of aldosterone, 18-OHB and B. The above results obtained in vivo and in vitro suggest that ANP inhibits corticosterone methyloxidase II activity and dopamine inhibits corticosterone methyloxidase I activity. However, from the present study we were unable to specify the action of ouabain on the synthesis of aldosterone and its related substances.

Endogenous Natriuretic Factors 2

1993 ◽  
Vol 22 (Supplement 2) ◽  
pp. S63-S68 ◽  
Author(s):  
Barry H. Levine ◽  
David E. Murray ◽  
Annette E. Bigornia ◽  
Sally A. DeWind ◽  
William J. Wechter
Keyword(s):  
Natriuretic Factors
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