Effective risk stratification of surgical and nonsurgical patients for venous thromboembolic disease

2001 ◽  
Vol 38 (2, Suppl 5) ◽  
pp. 12-19 ◽  
Author(s):  
Joseph A. Caprini ◽  
Juan I. Arcelus ◽  
Jos[eacute] J. Reyna
Keyword(s):  
Risk Stratification ◽  
Thromboembolic Disease ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic ◽  
Nonsurgical Patients

Monitoring Heparin Therapy: Relationships between the Activated Partial Thromboplastin Time and Heparin Assays Based on Ex-Vivo Heparin Samples

1990 ◽  
Vol 63 (01) ◽  
pp. 016-023 ◽  
Author(s):  
A M H P van den Bessekaar ◽  
J Meeuwisse-Braun ◽  
R M Bertina
Keyword(s):  
Partial Thromboplastin Time ◽  
Plasma Sample ◽  
Ex Vivo ◽  
Correlation Coefficients ◽  
Heparin Therapy ◽  
Thromboembolic Disease ◽  
Activated Partial Thromboplastin Time ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic

SummaryFive different APTT reagents, two amidolytic anti-ITa assays, one amidoiytic anti-Xa assay, and one coagulometric anti-Xa/ anti-IIa assay were used to assess the effect of heparin in patients treated for venous thromboembolic disease. Good correlations were observed between lug-transformed APYE> determined with the various reagents (correlation coefficients: 0.92-0.96).Nevertheless there were important differences in the slopes of the lines of relationship between the APTT reagents.Good correlations were observed between the anti-Xa and anti-IIa assay results (correlation coefficients: 0.92-0.97). However, the amidolytic anti-Xa activity was significantly higher (p <0.001) than the two amidolytic anti-IIa activities. Less good correlations were observed between the log-transformed APTTs and the anti-Xa or anti-IIa activities (correlation coefficients: 0.64-0.78). The correlations were improved by transforming the APTT into APTT-ratio, i.e. the ratio of the patient’s APTT to the same patient’s APTT after removal of heparin from the plasma sample by means of ECTEOLA-cellulose treatment. The correlation coefficients of log (AFTT-ratio) with anti-Xa or anti-IIa ranged from 0.76 to 0.87.For both APTT and amidolytic heparin assay, the response to in vitro heparin was different from the response to ex vivo heparin.Therefore, equivalent therapeutic ranges should be assessed by using ex vivo samples rather than in vitro heparin. Because of the response differences between the APTT reagents, it is not adequate to define a therapeutic range for heparin therapy without specification of the reagent.

Periodontitis as A Risk Factor of Unprovoked Venous Thromboembolic Disease: An Emerging Association

2018 ◽  
Vol 2 (12) ◽  
Author(s):  
Nifosì Lorenzo ◽  
Zuccarello Mariateresa ◽  
Nifosì Antonio Fabrizio ◽  
Hervas Saus Vanessa ◽  
Nifosì Gianfilippo
Keyword(s):  
Risk Factor ◽  
Thromboembolic Disease ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic

Venous Thromboembolic Disease in Urological Practice

1959 ◽  
Vol 81 (1) ◽  
pp. 215-218 ◽  
Author(s):  
Earl P. Galleher ◽  
William G. Anlyan
Keyword(s):  
Thromboembolic Disease ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic
Sign in / Sign up

Export Citation Format

Share Document