Gabapentin produces dose-dependent antinociception in the orofacial formalin test in the rat☆

2002 ◽  
Vol 27 (3) ◽  
pp. 277-283 ◽  
Author(s):  
T GRABOW ◽  
P DOUGHERTY
Keyword(s):  
Formalin Test ◽  
Dose Dependent ◽  
Orofacial Formalin Test

Characterization of rat ultrasonic vocalization in the orofacial formalin test: Influence of the social context

2019 ◽  
Vol 29 (11) ◽  
pp. 1213-1226 ◽  
Author(s):  
Amanda Ribeiro Barroso ◽  
Erika Ivanna Araya ◽  
Camila Pasquini de Souza ◽  
Roberto Andreatini ◽  
Juliana Geremias Chichorro
Keyword(s):  
Social Context ◽  
Formalin Test ◽  
Ultrasonic Vocalization ◽  
The Social ◽  
Orofacial Formalin Test

Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice

2015 ◽  
Vol 67 (2) ◽  
pp. 399-403 ◽  
Author(s):  
Hugo F. Miranda ◽  
Fernando Sierralta ◽  
Sebastian Lux ◽  
Rocío Troncoso ◽  
Natalia Ciudad ◽  
...  
Keyword(s):  
Formalin Test ◽  
Orofacial Formalin Test

The orofacial formalin test

2004 ◽  
Vol 28 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Patrick Raboisson ◽  
Radhouane Dallel
Keyword(s):  
Formalin Test ◽  
Orofacial Formalin Test

Sex differences in the effects of amiloride on formalin test nociception in mice

2006 ◽  
Vol 291 (2) ◽  
pp. R335-R342 ◽  
Author(s):  
Mona Lisa Chanda ◽  
Jeffrey S. Mogil
Keyword(s):  
Sex Differences ◽  
Sex Difference ◽  
Formalin Test ◽  
Testosterone Propionate ◽  
Nociceptive Behavior ◽  
Acid Sensing Ion Channels ◽  
Inflammatory Nociception ◽  
Dose Dependent ◽  
Tonic Phase

Amiloride is a nonspecific blocker of acid-sensing ion channels (ASICs) that have been recently implicated in the mediation of mechanical and chemical/inflammatory nociception. Preliminary data using a transgenic model are suggestive of sex differences in the role of ASICs. We report here that systemic administration of amiloride (10–70 mg/kg ip) produces a robust, dose-dependent blockade of late/tonic phase nociceptive behavior on the mouse formalin test (5%; 20 μl) in female but not male mice, completely abolishing the known sex difference in formalin test response. Adult gonadectomy produced a “switching” of sex differences in amiloride efficacy, with castrated males displaying an amiloride blockade and ovariectomized females rendered less sensitive to amiloride. Gonadectomized mice could be switched back to their intact status using chronic estrogen benzoate or testosterone propionate replacement via osmotic minipump (6 μg/day or 250 μg/day, respectively). It is unclear whether this striking sex difference is due to sex-specific involvement of ASICs in pain processing, but the present data represent one of the first demonstrations of pain-related sex differences with no obvious opioid involvement.

Antinociceptive effect of Er:YAG laser irradiation in the orofacial formalin test

2005 ◽  
Vol 1032 (1-2) ◽  
pp. 149-153 ◽  
Author(s):  
Jorge L. Zeredo ◽  
Katia M. Sasaki ◽  
Yoshinari Takeuchi ◽  
Kazuo Toda
Keyword(s):  
Laser Irradiation ◽  
Formalin Test ◽  
Er:Yag Laser ◽  
Antinociceptive Effect ◽  
Orofacial Formalin Test

Intracisternal NMDA produces analgesia in the orofacial formalin test of freely moving rats

2004 ◽  
Vol 28 (3) ◽  
pp. 497-503 ◽  
Author(s):  
Ho Jeong Lee ◽  
Hyo Soon Choi ◽  
Chang Young Jung ◽  
Jin Sook Ju ◽  
Sung Kyo Kim ◽  
...  
Keyword(s):  
Formalin Test ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Orofacial Formalin Test

scholarly journals Pharmacokinetics and Pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat

2016 ◽  
Vol 11 (3) ◽  
pp. 68 ◽  
Author(s):  
María R León-Reyes ◽  
Gilberto Castañeda-Hernández ◽  
Mario I Ortiz
Keyword(s):  
Formalin Test ◽  
Antinociceptive Effect ◽  
Dorsal Surface ◽  
Pharmacokinetic Interaction ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Female Wistar Rats ◽  
Inflammatory Drugs ◽  
The Right ◽  
Dose Dependent ◽  
Analgesic Response

PURPOSE. There are evidences that glibenclamide, a sulfonylurea antidiabetic agent, reduces the analgesic action of non-steroidal anti-inflammatory drugs (NSAIDs), opioids and neuromodulators in animal models. The purpose of this work was to examine in the rat if such interaction involves pharmacokinetic mechanisms or is solely limited to the pharmacodynamic level. METHODS. All studies were carried out in female Wistar rats. Analgesia was assessed using the formalin test. Fifty microliters of diluted formalin was injected subcutaneously into the dorsal surface of the right hind paw. Nociceptive behavior was quantified as the number of flinches of the injected paw during 60 min after injection and a reduction in formalin-induced flinching was interpreted as an analgesic response. Rats were treated with oral diclofenac (3-18 mg/kg) in presence and the absence of oral glibenclamide (1-30 mg/kg). To evaluate the possibility of a pharmacokinetic interaction, the oral bioavailability of diclofenac (18 mg/kg) was studied in presence and the absence of glibenclamide (10 mg/kg). RESULTS. Oral administration of diclofenac produced a dose-dependent antinociceptive effect in the formalin test. Coadministration of glibenclamide significantly reduced diclofenac-induced antinociception. Notwithstanding, the interaction does no appear to involve pharmacokinetic mechanisms, as oral glibenclamide failed to produce any significant alteration in oral diclofenac bioavailability. CONCLUSION. Concomitant systemic administration of glibenclamide and diclofenac results in a reduction of the analgesic effect of the NSAID in the formalin test in the rat. This interaction, however, appears due solely to a pharmacodynamic mechanisms as diclofenac pharmacokinetics are not altered.

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