The Characterization of Pregnancy Associated Plasma Protein-E and the Identification of an Alternative Splice Variant

Placenta ◽  
2001 ◽  
Vol 22 (8-9) ◽  
pp. 681-687 ◽  
Author(s):  
N.M. Page ◽  
D.J. Butlin ◽  
K. Lomthaisong ◽  
P.J. Lowry
Keyword(s):  
Alternative Splice ◽  
Plasma Protein ◽  
Splice Variant ◽  
Alternative Splice Variant

Identification and characterization of a novel alternative splice variant of mouse GMx33α/GPP34

Gene ◽  
2007 ◽  
Vol 400 (1-2) ◽  
pp. 82-88 ◽  
Author(s):  
Michiyo Nagano-Ito ◽  
Sae Yoshikawa ◽  
Mika Tamura ◽  
Mihoko Tsurumaki ◽  
Shinichi Ichikawa
Keyword(s):  
Alternative Splice ◽  
Splice Variant ◽  
Alternative Splice Variant ◽  
Identification And Characterization

scholarly journals Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog

2005 ◽  
Vol 37 (6) ◽  
pp. 601-607 ◽  
Author(s):  
Jung Sun Kim ◽  
Jiha Kim ◽  
Byung Soo Kim ◽  
Hee Yong Chung ◽  
Young Yiul Lee ◽  
...  
Keyword(s):  
Alternative Splice ◽  
Splice Variant ◽  
Functional Characterization ◽  
Alternative Splice Variant ◽  
Fourth Exon

scholarly journals Characterization of an Alternative Splice Variant of LKB1

2008 ◽  
Vol 284 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Fiona C. Denison ◽  
Natalie J. Hiscock ◽  
David Carling ◽  
Angela Woods
Keyword(s):  
Alternative Splice ◽  
Splice Variant ◽  
Alternative Splice Variant

Characterization of three alternative splice variants associated with the Arabidopsis rhomboid protein gene At1g74130

Botany ◽  
2013 ◽  
Vol 91 (12) ◽  
pp. 840-849 ◽  
Author(s):  
Joshua Powles ◽  
Katharine Sedivy-Haley ◽  
Eric Chapman ◽  
Kenton Ko
Keyword(s):  
Alternative Splicing ◽  
Alternative Splice ◽  
Splice Variant ◽  
Serine Proteases ◽  
Transmembrane Domain ◽  
Splice Variants ◽  
Genes Encoding ◽  
Different Characteristics ◽  
Alternative Splice Variants

Rhomboid serine proteases are grouped into three main types — secretases, presenilin-like associated rhomboid-like (PARL) proteases, and “inactive” rhomboid proteins. Although the three rhomboid groups are distinct, the different types are likely to operate within the same cell or compartment, such as observed in the plastids of Arabidopsis. There are four distinct plastid rhomboid genes at play in Arabidopsis plastids, two for active types (At1g25290 and At5g25752) and two for inactive forms (At1g74130 and At1g74140). The number of working plastid rhomboids is further increased by alternative splicing, as reported for At1g25290. To understand how the plastid rhomboid system works, it is necessary to identify all rhomboid forms in play. To this end, this study was designed to examine the alternative splicing activities of At1g74130, one of the two genes encoding proteolytically “inactive” plastid rhomboids. The exon mapping and DNA sequencing results obtained here indicate the presence of three prominent alternative splice variants in the At1g74130 transcript population. The dominant splice variant, L, encodes the full-length protein. The other two splice variants, M and S, produce proteins lacking sections from the carboxyl transmembrane domain region. The splice variants M and S appear to be at levels with functional potential and appear to adjust relative to each other during development and in response to changes in the level of Tic40, a component of the plastid translocon. The splice variant proteins themselves exhibit different characteristics with respect to rhomboid protein–substrate interactions. These differences were observed in bacterial co-expression pull-down assays and in yeast mitochondrial studies. When considered together, the data suggest that the alternative splicing of At1g74130 bears functional significance in Arabidopsis and is likely to be part of a mechanism for diversifying plastid rhomboid function.

scholarly journals Differentiating Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase in Thyroid Neoplasms

Thyroid ◽  
2008 ◽  
Vol 18 (10) ◽  
pp. 1055-1063 ◽  
Author(s):  
Yongchun Wang ◽  
Jeanne Kowalski ◽  
Hua-Ling Tsai ◽  
Radharani Marik ◽  
Nijaguna Prasad ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Alternative Splice ◽  
Splice Variant ◽  
Thyroid Neoplasms ◽  
Telomerase Reverse Transcriptase ◽  
Alternative Splice Variant ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

scholarly journals DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

2020 ◽  
Vol 19 (7) ◽  
pp. 1539-1549 ◽  
Author(s):  
Parthasarathy Chandrakesan ◽  
Janani Panneerselvam ◽  
Randal May ◽  
Nathaniel Weygant ◽  
Dongfeng Qu ◽  
...  
Keyword(s):  
Alternative Splice ◽  
Splice Variant ◽  
Pancreatic Tumor ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Alternative Splice Variant ◽  
M2 Macrophage Polarization
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