Letter to the Editor: Response to Dr Lala's letter–The effects of angiogenic growth factors on extravillous trophoblast invasion and motility

Placenta ◽  
2000 ◽  
Vol 21 (5-6) ◽  
pp. 594-595
Author(s):  
G. Lash ◽  
G. Whitley ◽  
J. Cartwright ◽  
P. Baker
Keyword(s):  
Growth Factors ◽  
Extravillous Trophoblast ◽  
Trophoblast Invasion ◽  
Angiogenic Growth Factors ◽  
Letter To The Editor

The Effects of Angiogenic Growth Factors on Extravillous Trophoblast Invasion and Motility

Placenta ◽  
1999 ◽  
Vol 20 (8) ◽  
pp. 661-667 ◽  
Author(s):  
G.E Lash ◽  
J.E Cartwright ◽  
G.St J Whitley ◽  
A.J Trew ◽  
P.N Baker
Keyword(s):  
Growth Factors ◽  
Extravillous Trophoblast ◽  
Trophoblast Invasion ◽  
Angiogenic Growth Factors

The effects of angiogenic growth factors on first trimester trophoblast invasion and proliferation

Placenta ◽  
2015 ◽  
Vol 36 (9) ◽  
pp. A22-A23
Author(s):  
Prabha Andraweera ◽  
Amanda Highet ◽  
Gary Heinemann ◽  
Claire Roberts
Keyword(s):  
Growth Factors ◽  
First Trimester ◽  
Trophoblast Invasion ◽  
Angiogenic Growth Factors

Secretion of Angiogenic Growth Factors by Villous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy

Placenta ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 545-548 ◽  
Author(s):  
G.E. Lash ◽  
K. Naruse ◽  
B.A. Innes ◽  
S.C. Robson ◽  
R.F. Searle ◽  
...  
Keyword(s):  
Growth Factors ◽  
Extravillous Trophoblast ◽  
Angiogenic Growth Factors ◽  
Human Pregnancy ◽  
Early Human

Angiogenesis: molecular mechanisms and functional interactions

2003 ◽  
Vol 89 (01) ◽  
pp. 190-197 ◽  
Author(s):  
Georg Breier ◽  
Hellmut Augustin
Keyword(s):  
Growth Factors ◽  
Research Program ◽  
Tumor Invasion ◽  
Molecular Mechanisms ◽  
Precursor Cells ◽  
Invasion And Metastasis ◽  
Angiogenic Growth Factors ◽  
Cell Contacts ◽  
Functional Interactions ◽  
Biannual Meeting

SummaryThe German Priority Research Program “Angiogenesis” (www.angiogenese.de) hosts a biannual meeting in the Kloster Seeon in Southern Germany. The 2nd Kloster Seeon Meeting “Angiogenesis: Molecular Mechanisms and Functional Interactions” was held in September 2002. It included sessions on hypoxia, the biology of endothelial precursor cells, angiogenic growth factors including VEGFs, the angiopoietins, ephrins, and FGFs, mechanisms of vascular sprouting and cell-cell contacts during angiogenesis, angiogenic signaling, lymphangiogenesis, angiogenesis during tumor invasion and metastasis, and on novel angiomanipulatory therapies. This report summarizes the key findings reported during the platform presentations of the meeting.

scholarly journals Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xiao-Hui Wang ◽  
Sha Xu ◽  
Xiang-Yu Zhou ◽  
Rui Zhao ◽  
Yan Lin ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Embryo Implantation ◽  
Underlying Mechanism ◽  
Recurrent Spontaneous Abortion ◽  
Extravillous Trophoblast ◽  
Trophoblast Invasion ◽  
Iron Sulfur ◽  
Succinate Dehydrogenase Complex ◽  
Extravillous Trophoblasts ◽  
Control Study

AbstractDysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, compared to healthy controls, display reduced succinate dehydrogenase complex iron sulfur subunit (SDHB) DNA methylation, elevated SDHB expression, and reduced succinate levels, indicating that low succinate levels correlate with RSA. Moreover, we find high succinate levels in early pregnant women are correlated with successful embryo implantation. SDHB promoter methylation recruited MBD1 and excluded c-Fos, inactivating SDHB expression and causing intracellular succinate accumulation which mimicked hypoxia in extravillous trophoblasts cell lines JEG3 and HTR8 via the PHD2-VHL-HIF-1α pathway; however, low succinate levels reversed this effect and increased the risk of abortion in mouse model. This study reveals that abnormal metabolite levels inhibit extravillous trophoblast function and highlights an approach for RSA intervention.

Roles of TGF-β Superfamily Proteins in Extravillous Trophoblast Invasion

2021 ◽  
Vol 32 (3) ◽  
pp. 170-189
Author(s):  
Yan Li ◽  
Junhao Yan ◽  
Hsun-Ming Chang ◽  
Zi-Jiang Chen ◽  
Peter C.K. Leung
Keyword(s):  
Extravillous Trophoblast ◽  
Trophoblast Invasion
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