Downregulation of HLA Class I Gene Transcription in Choriocarcinoma Cells is Controlled by the Proximal Promoter Element and Can be Reversed by CIITA

Placenta ◽  
1999 ◽  
Vol 20 (4) ◽  
pp. 293-301 ◽  
Author(s):  
S. Lefebvre ◽  
P. Moreau ◽  
J. Dausset ◽  
E.D. Carosella ◽  
P. Paul
Keyword(s):  
Gene Transcription ◽  
Hla Class I ◽  
Class I ◽  
Proximal Promoter ◽  
Promoter Element ◽  
Choriocarcinoma Cells ◽  
I Gene

scholarly journals Upregulation of HLA class-I gene transcription in K562 cells by analogs of splenopentin (SP-5)

IUBMB Life ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 521-528 ◽  
Author(s):  
Moitreyee Chatterjee-Kishore ◽  
Suraksha Agrawal ◽  
VK Singh ◽  
KB Mathur ◽  
Shyam Agarwal
Keyword(s):  
Gene Transcription ◽  
Hla Class I ◽  
K562 Cells ◽  
Class I ◽  
I Gene

Regulation and modulation of classical HLA class I gene transcription in trophoblast cells and choriocarcinoma JEG-3 cells

1997 ◽  
Vol 56 ◽  
pp. 76
Author(s):  
S. Lefébvre ◽  
P. Moreau ◽  
C. Legoué ◽  
V. Gratio ◽  
L. Gourand ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Hla Class I ◽  
Class I ◽  
Trophoblast Cells ◽  
I Gene

scholarly journals Upregulation of HLA Class-I gene transcription in K562 cells by analogs of Splenopentin (SP-5)

IUBMB Life ◽  
1997 ◽  
Vol 43 (2) ◽  
pp. 463-463
Author(s):  
Moitreyee Chatterjee-Kishore ◽  
Suraksha Agrawal ◽  
Shyam Agarwal ◽  
V. K. Singh ◽  
K. B. Mathur ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Hla Class I ◽  
K562 Cells ◽  
Class I ◽  
I Gene

scholarly journals The Y-box Binding Protein YB-1 Suppresses Collagen α1(I) Gene Transcription via an Evolutionarily Conserved Regulatory Element in the Proximal Promoter

2001 ◽  
Vol 276 (32) ◽  
pp. 29880-29890 ◽  
Author(s):  
Jill T. Norman ◽  
Gisela E. Lindahl ◽  
Kaveh Shakib ◽  
Abdelaziz En-Nia ◽  
Emek Yilmaz ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Binding Protein ◽  
Regulatory Element ◽  
Proximal Promoter ◽  
Evolutionarily Conserved ◽  
I Gene

HLA Class I Gene Typing with an HLA-B-Specific DNA Probe

1984 ◽  
pp. 551-554 ◽  
Author(s):  
F. C. Grumet ◽  
L. Fish ◽  
J. Moossazedeh ◽  
D. Ness ◽  
B. Duceman
Keyword(s):  
Hla Class I ◽  
Dna Probe ◽  
Class I ◽  
Gene Typing ◽  
I Gene

scholarly journals Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.

1990 ◽  
Vol 171 (1) ◽  
pp. 1-18 ◽  
Author(s):  
D E Geraghty ◽  
X H Wei ◽  
H T Orr ◽  
B H Koller
Keyword(s):  
Dna Sequence ◽  
Hla Class I ◽  
Class I ◽  
Northern Analysis ◽  
Protein Sequence Analysis ◽  
Specific Expression ◽  
Rnase Protection ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
I Gene

We describe here the isolation and sequencing of a previously uncharacterized HLA class I gene. This gene, HLA-5.4, is the third non-HLA-A,B,C gene characterized whose sequence shows it encodes an intact class I protein. RNase protection assays with a probe specific for this gene demonstrated its expression in B lymphoblastoid cell lines, in resting T cells, and skin cells, while no mRNA could be detected in the T cell line Molt 4. Consistent with a pattern of expression different from that of other class I genes, DNA sequence comparisons identified potential regulator motifs unique to HLA-5.4 and possibly essential for tissue-specific expression. Protein sequence analysis of human and murine class I antigens has identified 10 highly conserved residues believed to be involved in antigen binding. Five of these are altered in HLA-5.4, and of these, three are nonconservative. In addition, examination of the HLA-5.4 DNA sequence predicts that the cytoplasmic segment of this protein is shorter than that of the classical transplantation antigens. The 3' untranslated region of the HLA-5.4 gene contains one member of a previously undescribed multigene family consisting of at least 30 members. Northern analysis showed that several of these sequences were transcribed, and the most ubiquitous transcript, a 600-nucleotide polyadenylated mRNA, was found in all tissues and cells examined. This sequence is conserved in the mouse genome, where a similar number of copies were found, and one of these sequences was also transcribed, yielding a 600-nucleotide mRNA. The characterization of this unique HLA class I gene and the demonstration of its tissue-specific expression have prompted us to propose that HLA-5.4 be designated HLA-F.

DNA-binding proteins for transcription enhancing region of HLA class I gene

1993 ◽  
Vol 42 (2) ◽  
pp. 78-86
Author(s):  
Jeon Han Park ◽  
Hang Woog Lee ◽  
Katharina L. Fleischhauer ◽  
Chul Gun Kim ◽  
Michael Sheffery ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Proteins ◽  
Hla Class I ◽  
Dna Binding Proteins ◽  
Class I ◽  
I Gene
Sign in / Sign up

Export Citation Format

Share Document