Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus

Metabolism ◽  
2003 ◽  
Vol 52 (2) ◽  
pp. 192-198 ◽  
Author(s):  
K. Goya ◽  
M. Otsuki ◽  
X. Xu ◽  
S. Kasayama
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Beraprost Sodium ◽  
Cell Adhesion Molecule 1

scholarly journals Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma.

1995 ◽  
Vol 181 (2) ◽  
pp. 811-816 ◽  
Author(s):  
L Piali ◽  
A Fichtel ◽  
H J Terpe ◽  
B A Imhof ◽  
R H Gisler
Keyword(s):  
Cell Adhesion ◽  
Immune System ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Endothelial Cells ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Tumor Metastases ◽  
Cell Adhesion Molecule 1

Vascular cell adhesion molecule 1 (VCAM-1) mediates extravasation of circulating leukocytes into inflamed tissues, and presumably, plays a role in the immigration of cytotoxic effector lymphocytes into tumor metastases. Since metastases are rarely cleared by blood-borne cells from the immune system, we asked whether the tumor may escape host defense by interfering with the mechanism of effector cell extravasation. Here we show that in mice and humans, VCAM-1 expression is repressed on tumor-infiltrating vascular endothelial cells in the lungs. On lung blood vessels distant from the tumor, VCAM-1 is constitutively expressed. When melanoma and endothelioma cells were cultured on either side of a Nucleopore membrane, the expression of VCAM-1 on the endothelioma cells was inhibited and VCAM-1 gene transcription was suppressed. We propose that the downregulation of VCAM-1 is a mechanism by which vascularized melanoma and carcinoma avoid invasion by cytotoxic cells of the immune system.

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