Aerobic exercise training improves insulin sensitivity independent of plasma tumor necrosis factor-alpha levels in older female hypertensives

Metabolism ◽  
2002 ◽  
Vol 51 (11) ◽  
pp. 1402-1406 ◽  
Author(s):  
Thomas H. Reynolds ◽  
Michael D. Brown ◽  
Mark A. Supiano ◽  
Donald R. Dengel
Keyword(s):  
Insulin Sensitivity ◽  
Tumor Necrosis Factor ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Aerobic Exercise Training ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance

2001 ◽  
pp. 273-280 ◽  
Author(s):  
M Straczkowski ◽  
I Kowalska ◽  
S Dzienis-Straczkowska ◽  
A Stepien ◽  
E Skibinska ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Tumor Necrosis Factor ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Tumor Necrosis ◽  
Obese Women ◽  
Necrosis Factor Alpha ◽  
Exercise Training Program ◽  
Factor Alpha ◽  
Necrosis Factor

OBJECTIVE: Tumor necrosis factor-alpha (TNFalpha) plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. Plasma levels of the soluble (s) fractions of TNFalpha receptors, especially sTNFR2, are good indicators of TNFalpha system activation in obesity. The aim of the present study was to assess the effect of exercise training on the TNFalpha system and to evaluate the relationship with changes in insulin sensitivity. DESIGN AND METHODS: Sixteen obese women (body mass index (BMI)>27.8 kg/m(2)), 8 with normal (NGT) and 8 with impaired glucose tolerance (IGT), participated in an exercise training program which lasted for 12 weeks and included exercise performed on a bicycle ergometer at an individual intensity of 70% maximal heart rate, for 30 min, 5 days a week. Anthropometrical measurements and blood biochemical analyses were performed, and plasma TNFalpha, sTNFR1 and sTNFR2 levels were assessed. Insulin sensitivity was evaluated using the hyperinsulinemic euglycemic clamp technique (insulin infusion: 50 mU x kg(-1)xh(-1)). RESULTS: At baseline, despite similar anthropometrical parameters, IGT subjects were markedly more insulin resistant and had higher TNFalpha and sTNFR2 concentrations. Exercise training increased insulin sensitivity and decreased TNFalpha and sTNFR2 levels, while sTNFR1 remained unchanged. The decrease in sTNFR2 was significantly related to the increase in insulin sensitivity; that relationship remained significant after adjustment for the concurrent changes in BMI, waist circumference, percentage of body fat, plasma glucose, insulin and free fatty acids. CONCLUSIONS: Regular physical exercise decreases TNFalpha system activity and that decrease may be responsible for the concurrent increase in insulin sensitivity.

Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up

2007 ◽  
Vol 17 (9) ◽  
pp. 1242-1247 ◽  
Author(s):  
José Antonio Robles-Cervantes ◽  
Esperanza Martínez-Abundis ◽  
Manuel González-Ortiz ◽  
Lázaro Cárdenas-Camarena ◽  
Eduardo Hernández-Salazar ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Obese Women ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up

2007 ◽  
Vol 17 (9) ◽  
pp. 1242-1247
Author(s):  
José Antonio Robles-Cervantes ◽  
Esperanza Martínez-Abundis ◽  
Manuel González-Ortiz ◽  
Lázaro Cárdenas-Camarena ◽  
Eduardo Hernández-Salazar ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Obese Women ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Olmesartan Ameliorates Insulin Sensitivity by Modulating Tumor Necrosis Factor-.ALPHA. and Cyclic AMP in Skeletal Muscle

2005 ◽  
Vol 28 (9) ◽  
pp. 773-778 ◽  
Author(s):  
Koichi YAMAGUCHI ◽  
Nobuyuki URA ◽  
Hideyuki MURAKAMI ◽  
Nobuhiko TOGASHI ◽  
Masaya HYAKUKOKU ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Tumor Necrosis Factor ◽  
Cyclic Amp ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Effect of Intense Exercise Training on Hydrogen Peroxide, Tumor Necrosis Factor-Alpha and the Selected Neurotrophins in Rat’s Brain

2015 ◽  
Vol 20 (4) ◽  
pp. 231-236
Author(s):  
حسین Taheri Chadorneshin H. ◽  
محمد اسماعیل Afzalpour M.E. ◽  
سیدحسین Abtahi H. ◽  
محسن Foadoddini M. ◽  
◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Tumor Necrosis Factor ◽  
Exercise Training ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Intense Exercise ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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