Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals

Metabolism ◽  
2002 ◽  
Vol 51 (9) ◽  
pp. 1111-1119 ◽  
Author(s):  
Masafumi Matsuda ◽  
Ralph A. DeFronzo ◽  
Leonard Glass ◽  
Agostino Consoli ◽  
Mauro Giordano ◽  
...  
Keyword(s):  
Response Curve ◽  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Glucose Disposal ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Normal Individuals ◽  
Hepatic Glucose ◽  
Type 2 Diabetic

Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients

2007 ◽  
Vol 292 (1) ◽  
pp. E347-E352 ◽  
Author(s):  
Marina Cardellini ◽  
Maria Adelaide Marini ◽  
Simona Frontoni ◽  
Marta Letizia Hribal ◽  
Francesco Andreozzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Cell ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Glucose Disposal ◽  
Diabetic Patients ◽  
Blood Cell Count ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

The aim of this study was to investigate whether insulin resistance is independently associated with early manifestations of atherosclerosis. To this end, 176 normotensive offspring of type 2 diabetic patients were subjected to euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Early atherosclerosis was studied by ultrasonography of the common carotid artery. Of the total 176 subjects, 145 were glucose tolerant, 18 had impaired fasting glucose, and 13 had impaired glucose tolerance. Univariate correlations showed that age, body mass index, waist, blood pressure, 2-h postchallenge glucose, fasting insulin, triglycerides, interleukin-6, fibrinogen, and white blood cell count were significantly correlated with carotid intima-media thickness (IMT), whereas HDL cholesterol and glucose disposal showed a negative correlation. A stepwise multivariate regression analysis including sex, age, waist circumference, smoking status, systolic blood pressure, diastolic blood pressure, triglyceride, HDL cholesterol, 2-h postchallenge glucose, plasma IL-6, fibrinogen, white blood cell count, insulin-stimulated glucose disposal, and fasting insulin showed that the four variables that remained significantly associated with carotid IMT were waist circumference, insulin-stimulated glucose disposal, white blood cell count, and diastolic blood pressure, accounting for 33.7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients.

scholarly journals Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

Diabetologia ◽  
2008 ◽  
Vol 51 (10) ◽  
pp. 1893-1900 ◽  
Author(s):  
H. Boon ◽  
M. Bosselaar ◽  
S. F. E. Praet ◽  
E. E. Blaak ◽  
W. H. M. Saris ◽  
...  
Keyword(s):  
Whole Body ◽  
Diabetic Patients ◽  
Hepatic Glucose Output ◽  
Type 2 Diabetic Patients ◽  
Hepatic Glucose ◽  
Glucose Output ◽  
Type 2 Diabetic

L-Carnitine Improves Glucose Disposal in Type 2 Diabetic Patients

1999 ◽  
Vol 18 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Geltrude Mingrone ◽  
Aldo V. Greco ◽  
Esmeralda Capristo ◽  
Giuseppe Benedetti ◽  
Annalisa Giancaterini ◽  
...  
Keyword(s):  
Glucose Disposal ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Type 2 diabetic patients may have a mild form of an injury response: a clinical research center study

2002 ◽  
Vol 282 (6) ◽  
pp. E1286-E1290 ◽  
Author(s):  
Arthur P. Richardson ◽  
John A. Tayek
Keyword(s):  
Glucose Production ◽  
Serum Cortisol ◽  
Metabolic Changes ◽  
Glucose Disposal ◽  
Diabetic Patients ◽  
Injury Response ◽  
Type 2 Diabetic Patients ◽  
Counterregulatory Hormones ◽  
Lung Cancer Patients

Patients with type 2 diabetes (DM) demonstrate inadequate insulin release, elevated gluconeogenesis, and diminished nonoxidative glucose disposal. Similar metabolic changes occur during systemic injury caused by infection, trauma, or cancer. Described here are metabolic changes occurring in 16 DM and 11 lung cancer patients (CA) and 13 normal volunteers (NV). After a 10-h overnight fast, all subjects had fasting hormone and substrate concentrations determined, along with rates of glucose production, leucine appearance (LA), and leucine oxidation (LO). Fasting insulin (data not shown) and C-peptide concentrations were elevated in DM and CA compared with weight-matched NV (0.72 ± 0.09 and 0.64 ± 0.08 vs. 0.51 ± 0.03 mg/l, P < 0.05). C-reactive protein concentration was elevated in CA compared with DM and NV (23.3 ± 6.0 vs. 4.2 ± 1.4 and 2.1 ± 0.5 mg/l, P < 0.01). All counterregulatory hormones were normal except for serum cortisol (11.4 ± 1.0 and 12.1 ± 1.0 vs. 8.9 ± 0.7 μg/dl, DM and CA vs. NL, respectively, P < 0.05). Glucose production was increased in DM and CA compared with NV (4.22 ± 0.6 and 3.53 ± 0.3 vs. 2.76 ± 0.2 mg · kg lean body wt−1 · min−1, P < 0.01). LO and LA were increased in DM and CA compared with NV (LO: 27.3 ± 1.5 and 19.7 ± 1.5 vs. 12.5 ± 1.1 mmol · kg lean body wt−1 · min−1, P < 0.05; LA: 91.9 ± 6.6 and 90.7 ± 7.0 vs. 79.1 ± 6.0 mmol · kg lean body wt−1 · min−1, P < 0.01). DM share similar metabolic derangements with CA. The increase in LA may be secondary to an increased glucose production where amino acids are mobilized to provide the liver with adequate substrate to make glucose. The increase in glucose production may also be part of the injury response, or it may represent a form of insulin resistance that exists in both the DM and (non-DM) CA patients.

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