Serum leptin concentrations in children with type 1 diabetes mellitus: Relationship to body mass index, insulin dose, and glycemic control

Metabolism ◽  
2002 ◽  
Vol 51 (3) ◽  
pp. 292-296 ◽  
Author(s):  
Ashraf T. Soliman ◽  
Magdi Omar ◽  
Hala M. Assem ◽  
Ibrahim S. Nasr ◽  
Mohamed M. Rizk ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Insulin Dose ◽  
Serum Leptin

Allergic sensitization and symptoms, body mass index, and respiratory function in children with type 1 diabetes mellitus

2012 ◽  
Vol 108 (2) ◽  
pp. 128-129 ◽  
Author(s):  
Maria Angela Tosca ◽  
Michela Silvestri ◽  
Roberta Olcese ◽  
Giuseppe D'Annunzio ◽  
Angela Pistorio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Respiratory Function ◽  
Allergic Sensitization

Is the change in body mass index among children newly diagnosed with type 1 diabetes mellitus associated with obesity at transition from pediatric to adult care?

2016 ◽  
Vol 17 (8) ◽  
pp. 599-607 ◽  
Author(s):  
Taru Manyanga ◽  
Elizabeth AC Sellers ◽  
Brandy A Wicklow ◽  
Malcolm Doupe ◽  
Randall Fransoo
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Newly Diagnosed ◽  
Adult Care

scholarly journals Long-Term Mortality and Incidence of Renal Dialysis and Transplantation in Type 1 Diabetes Mellitus

2006 ◽  
Vol 91 (10) ◽  
pp. 3814-3820 ◽  
Author(s):  
M. Stadler ◽  
M. Auinger ◽  
C. Anderwald ◽  
T. Kästenbauer ◽  
R. Kramar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Confidence Interval ◽  
Creatinine Clearance ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Long Term Mortality

Abstract Aims: We investigated long-term mortality and requirement of renal replacement therapy (RRT) in type 1 diabetes mellitus (T1DM) to study risk factors and late complication incidence of T1DM in a prospective cohort study at Lainz Hospital, Vienna, Austria. Methods: In 1983–1984, T1DM patients [n = 648; 47% females, 53% males; age, 30 ± 11 yr; T1DM duration, 15 ± 9 yr; body mass index, 24 ± 4 kg/m2; glycated hemoglobin (HbA1c), 7.6 ± 1.6%] were stratified into HbA1c quartiles [1st, 5.9 ± 0.5% (range, 4.2–6.5%); 2nd, 6.9 ± 0.3% (6.6–7.4%); 3rd, 7.9 ± 0.3% (7.5–8.4%); and 4th, 9.6 ± 1.3% (8.5–14.8%)]. Twenty years later, both endpoints (death and RRT) were investigated by record linkage with national registries. Results: At baseline, creatinine clearance, blood pressure, and body mass index were comparable among the HbA1c quartiles, whereas albuminuria was more frequent in the 4th quartile (+15%; P < 0.03). After the 20-yr follow-up, 13.0% of the patients had died [rate, 708 per 100,000 person-years (95% confidence interval, 557–859)], and 5.6% had received RRT [311 per 100,000 person-years (95% confidence interval, 210–412)]. Patients with the highest HbA1c values (4th quartile) had a higher mortality rate and a greater incidence of RRT (P < 0.04). In the Cox proportional hazards analysis, age, male gender, increased HbA1c, albuminuria, and reduced creatinine clearance were predictors of mortality (P < 0.05). Predictors of RRT were albuminuria (P < 0.001), reduced creatinine clearance (P < 0.001), and belonging to the 4th HbA1c quartile (P = 0.06). In Kaplan-Meier analysis, mortality was linearly associated with poor glycemia, whereas RRT incidence appeared to rise at a HbA1c threshold of approximately 8.5%. Conclusion/Interpretation: In the Lainz T1DM cohort, 13.0% mortality and 5.6% RRT were directly associated with and more frequently found in poor glycemia, showing that good glycemic control is essential for the longevity and quality of life in T1DM.

Not as skinny as we used to think: Body mass index in children and adolescents at diagnosis of type 1 diabetes mellitus

2016 ◽  
Vol 30 (2) ◽  
pp. 292-294 ◽  
Author(s):  
Taru Manyanga ◽  
Elizabeth A.C. Sellers ◽  
Brandy A. Wicklow ◽  
Malcolm Doupe ◽  
Randall Fransoo
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Body Mass

scholarly journals Leptin levels in non-obese and obese children and young adults with type 1 diabetes mellitus

1998 ◽  
pp. 49-53 ◽  
Author(s):  
A Verrotti ◽  
F Basciani ◽  
G Morgese ◽  
F Chiarelli
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Patients ◽  
Serum Leptin ◽  
Insulin Dependent ◽  
Children And Young Adults

OBJECTIVE: To evaluate serum leptin levels in children and young adults with type 1 (insulin-dependent) diabetes mellitus and to investigate whether they are different in prepuberty, puberty and young adulthood. DESIGN: Three groups of diabetics (prepubertal, pubertal and young adults) subdivided into obese and non-obese were studied. Three groups of healthy subjects matched for sex, age and body mass index served as controls. RESULTS: Diabetic patients had serum leptin concentrations similar to those of controls in all three groups. A small non-significant increase in leptin from the prepubertal to the young adult age group for both diabetics and controls was found. A significant association of serum leptin level with body mass index (P < 0.001), female sex (P < 0.001) and age (P < 0.01) in both the diabetic and control group was present. Insulin-dependent diabetes was not associated with higher leptin concentration. CONCLUSIONS: Serum leptin concentrations are similar in diabetic patients and healthy controls. The association between obesity and leptin concentration was similar in the diabetic and non-diabetic subjects. Type 1 diabetes mellitus does not modify serum leptin concentration.

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