The effects of treatment with [alpha ]-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat

Metabolism ◽  
2001 ◽  
Vol 50 (8) ◽  
pp. 868-875 ◽  
Author(s):  
Isobel Ford ◽  
Mary A. Cotter ◽  
Norman E. Cameron ◽  
Michael Greaves
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Peripheral Nerve ◽  
Lipoic Acid ◽  
Nerve Conduction ◽  
Diabetic Rat ◽  
Alpha Lipoic Acid ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
Streptozotocin Diabetic Rat

scholarly journals The effectiveness of evening primrose oil and alpha lipoic acid in recovery of nerve function in diabetic rats

2011 ◽  
Vol 2 (3) ◽  
Author(s):  
Sherifa Ahmad Hamed ◽  
Alaa Eldeen Ahmed El-kossi ◽  
Mostafa Mahmoud Abdellah ◽  
Abeer Mohamed Rashad
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Alpha Lipoic Acid ◽  
Nerve Function ◽  
Evening Primrose Oil ◽  
Evening Primrose

scholarly journals Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat

1999 ◽  
Vol 195 (3) ◽  
pp. 419-427
Author(s):  
DAVID WALKER ◽  
ANNE CARRINGTON ◽  
SUSAN A. CANNAN ◽  
DIANE SAWICKI ◽  
JANET SREDY ◽  
...  
Keyword(s):  
Blood Flow ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Pain Threshold ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Fibre Density ◽  
Structural Abnormalities ◽  
Streptozotocin Diabetic Rat

The streptozotocin (STZ)-diabetic rat, the most commonly employed model of experimental diabetic neuropathy, is characterised by a reduction in nerve conduction velocity, pain threshold and blood flow. Whether or not structural abnormalities underlie these functional abnormalities is unclear. 10 adult male Sprague–Dawley STZ-diabetic rats (diabetes duration 27 d) and 10 age-matched (23 wk) control animals were studied. Motor nerve conduction velocity (m s−1) was significantly reduced in diabetic (41.31±0.8) compared with control (46.15±1.5) animals (P<0.001). The concentration of sciatic nerve glucose (P<0.001), fructose (P<0.001) and sorbitol (P<0.001) was elevated, and myoinositol (P<0.001) was reduced in diabetic compared with control animals. Detailed morphometric studies demonstrated no significant difference in fascicular area, myelinated fibre density, fibre and axon areas as well as unmyelinated fibre density and diameter. Endoneurial capillary density, basement membrane area and endothelial cell profile number did not differ between diabetic and control animals. However, luminal area (P<0.03) was increased and endothelial cell area (P<0.08) was decreased in the diabetic rats. We conclude there is no detectable structural basis for the reduction in nerve conduction velocity, pain threshold or blood flow, observed in the streptozotocin diabetic rat.

scholarly journals Effects of Alpha-Lipoic Acid Supplementation on Cardiovascular Disease Risk Factors in β-Thalassemia Major Patients: A Clinical Trial Crossover Study

2020 ◽  
Vol Volume 11 ◽  
pp. 131-139 ◽  
Author(s):  
Khadijeh Jamshidi ◽  
Hadi Abdollahzad ◽  
Mostafa Nachvak ◽  
Mansour Rezaei ◽  
Mohammad Reza Golpayegani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Clinical Trial ◽  
Crossover Study ◽  
Lipoic Acid ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Thalassemia Major ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation

Composite nanofibers incorporating alpha lipoic acid and atorvastatin provide neuroprotection after peripheral nerve injury in rats

2020 ◽  
Vol 153 ◽  
pp. 1-13
Author(s):  
Mohammad Karim Haidar ◽  
Selin Seda Timur ◽  
Atilla Kazanci ◽  
Omer Faruk Turkoglu ◽  
R. Neslihan Gürsoy ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Lipoic Acid ◽  
Peripheral Nerve Injury ◽  
Composite Nanofibers ◽  
Alpha Lipoic Acid
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