Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30

Metabolism ◽  
2001 ◽  
Vol 50 (7) ◽  
pp. 856-861 ◽  
Author(s):  
C.J. Glueck ◽  
R.N. Fontaine ◽  
Ping Wang ◽  
M.T.R. Subbiah ◽  
K. Weber ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Morbidly Obese ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Obese Subjects

scholarly journals CD36Gene Promoter Polymorphisms Are Associated With Low Density Lipoprotein-Cholesterol in Normal Twins and After a Low-Calorie Diet in Obese Subjects

2008 ◽  
Vol 11 (6) ◽  
pp. 621-628 ◽  
Author(s):  
Estibaliz Goyenechea ◽  
Laura J. Collins ◽  
Dolores Parra ◽  
Gaifen Liu ◽  
Harold Snieder ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Normal Female ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Obese Subjects

AbstractCommon polymorphisms of theCD36fatty acid transporter gene have been associated with lipid metabolism and cardiovascular disease. Association of aCD36promoter single nucleotide polymorphism genotype with anthropometry and serum lipids was investigated in normal subjects, and in obese subjects during an 8-week low calorie diet and 6-month weight-maintenance period. 2728 normal female Twins UK subjects (mean body mass index 24.8 ± 4.4 kg/m2; age 47.3 ± 12.5 y) and 183 obese male and female Spanish subjects (mean body mass index 30.6 ± 3.0 kg/m2; age 35.0 ± 5.0 y) were genotyped for theCD36-22674T/C(rs2151916) promoter single nucleotide polymorphism. In the Twins UK full cohort, theC-allele was associated with lower low density lipoprotein-cholesterol (p= .02,N= 2396). No associations were found in the obese Spanish subjects at baseline, but 6 months after the end of the low-calorie diet, theC-allele was associated with lower total- (p= .03) and low density lipoprotein-cholesterol (p= .01) and higher high density lipoprotein-cholesterol (p= .01). Intake of saturated fatty acids was lower in carriers of theC-allele at baseline, but not significantly so (p= .11). However, 6 months after the end of the low-calorie diet, elements of the lipid profile were correlated with saturated fatty acid intake: total cholesterolr= .21,p= .060; low density lipoprotein-cholesterol:r= .25,p= .043; high density lipoprotein-cholesterol:r= –.26,p= .007.CD36promoter SNP allele –22674Cis therefore associated with lower serum low-density lipoprotein-cholesterol in normal female twins and with improved lipid profile during weight loss and maintenance in obese subjects.

scholarly journals Association of body mass index with non-achievement of target low-density lipoprotein level in older patients at very high cardiovascular risk: a multicentre study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
H T Nguyen ◽  
A H Nguyen ◽  
H M Lam ◽  
T T Nguyen
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Body Mass ◽  
Older Patients ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
High Cardiovascular Risk ◽  
Very High

Abstract Introduction Low-density lipoprotein cholesterol (LDL-c) is a well-established risk factor for atherosclerotic cardiovascular disease. Nonetheless, the association of body mass index (BMI) with non-achievement of target LDL-c level in older patients with type 2 diabetes (T2D) at very high cardiovascular risk is unknown. Purpose To investigate whether BMI is associated with non-achievement of target LDL-c level in older patients with T2D at very high cardiovascular risk. Methods From December 2019 to June 2020, in this multicentre prospective cross-sectional study, we enrolled 733 consecutive outpatients aged ≥60 years with T2D at very high cardiovascular risk in whom LDL-c levels could be measured after any stable lipid-lowering therapy for ≥6 months. Achievement of target lipid level was assessed based on the 2019 guidelines of the European Society of Cardiology for dyslipidaemia. Factors associated with non-achievement of target LDL-c level were determined using logistic regression analysis. Results Of the total cases (age, 68.6±7.2 years; men, 51.3%), 654 patients (89.2%) did not achieve an aggressive target LDL-c level of <1.4 mmol/L. Target non-high-density lipoprotein cholesterol level of <2.2 mmol/L and triglyceride level of <1.7 mmol/L were not achieved in 87.9% and 56.2% of the patients, respectively. In the multivariate model, BMI was the only factor associated with failure to achieve target LDL-c level, but not other factors such as age, sex, education level, smoking, and comorbidities. The adjusted odds ratio were 0.88 (95% confidence interval [95% CI], 0.24–3.21; P=0.84) for underweight, 1.57 (95% CI, 0.87–2.81; P=0.13) for overweight, and 2.63 (95% CI, 1.43–4.83; P=0.002) for obesity (normal weight was set as reference) status. Conclusions Non-achievement of target LDL-c level is highly prevalent in older patients with T2D at very high cardiovascular risk. Obesity, defined by BMI, can be a factor associated with non-achievement of the target. The findings highlight the importance of management of lipid levels in older patients with T2D. FUNDunding Acknowledgement Type of funding sources: None. Figure 1

scholarly journals Comparative Assessment of the Magnitude of Hyperlipidemia in HIV-Infected Patients Receiving Lopinavir/r- and Atazanavir/r-Based Antiretroviral Drugs

2019 ◽  
Vol 18 ◽  
pp. 232595821984190
Author(s):  
Esther Muya ◽  
Appolinary Kamuhabwa
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Antiretroviral Drugs ◽  
Comparative Assessment ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Objective: To assess prevalence of hyperlipidemia in patients receiving lopinavir boosted with ritonavir (LPV/r) and atazanavir boosted with ritonavir (ATV/r) antiretroviral drugs. Methods: HIV-infected patients (300) were recruited in the study between December 2015 and April 2016. Lipid profile including triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) were assessed. Results: Prevalence of derangement in TG was 71.0% in patients using LPV/r compared to 44% in those using ATV/r ( P = .01). Use of LPV/r was independently associated with increased total cholesterol (TC; P = .001) and TG ( P = .0003). Females had raised levels of TC compared to males ( P = .00008). Body mass index of ≥ 25 kg/m2 was also associated with raised TC ( P = .002) and LDL-C ( P = .006). Conclusion: LPV/r was significantly associated with lipid derangements, indicating the need to regularly monitor lipid profile in patients using LPV/r.

scholarly journals FEATURES OF LIPID METABOLISM IN OVERWEIGHT AND OBESE ADOLESCENTS DEPENDING ON THE VARIOUS LEVELS OF VITAMIN D

2019 ◽  
pp. 37-43
Author(s):  
A-M. A. Shulhai ◽  
H. A. Pavlyshyn
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Lipid Metabolism ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Low Density Lipoprotein Cholesterol

Vitamin D deficiency and overweight have now become an important global problem in the field of health care as well as public health. A substantial hypovitaminosis D in children with obesity is often accompanied by metabolic disorders. The aim of the study was to determine the relationship between the levels of vitamin D and lipid metabolism markers in adolescents with overweight and obesity. Material and methods. 139 adolescents were examined (63 (45.4 %) girls and 76 (54.7 %) boys). Depending on the body mass index (BMI) 65 children were overweight and 74 were obese children. The mean age of teenagers was (15,4±2,3) years. To establish vitamin D status using the immune-enzyme method, blood serum levels of 25(OH)D were determined. Lipid metabolism markers were determined using the Roche Diagnostics Cholesterol reagent kit using and automatic Cobas c111 analyzer. Results. The study established a direct relationship between the level of vitamin D and high-density lipoprotein cholesterol and indirect with total cholesterol, triglycerides, low-density lipoprotein cholesterol, atherogenic index, body mass index and waist circumference. Using a simple linear regression analysis, it was determined that total cholesterol, low-density lipoprotein cholesterol and atherogenic index have the greatest correlation with vitamin D. Conclusions: Vitamin D deficiency in overweight and obese adolescents is associated with an increase in the body mass index, blood pressure, and atherogenic dyslipidemia.

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