Irregular circulating insulin concentrations in type 2 diabetes mellitus: An inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals

Metabolism ◽  
2001 ◽  
Vol 50 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Ole Schmitz ◽  
Claus B. Juhl ◽  
Malene Hollingdal ◽  
Johannes D. Veldhuis ◽  
Niels Pørksen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Time Series ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Inverse Relationship ◽  
Healthy Individuals

PP235-MON EFFECT OF MCT OIL ON FREE FATTY ACID PLASMA LEVELS IN MORBID OBESE PATIENTS WITH TYPE 2. DIABETES MELLITUS

2013 ◽  
Vol 32 ◽  
pp. S209-S210
Author(s):  
J. Lesna ◽  
A. Ticha ◽  
R. Hyspler ◽  
J. Borkovcova ◽  
S. Simkova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Levels ◽  
Obese Patients ◽  
Morbid Obese

scholarly journals Investigation of the free fatty acid receptor 2 and its role in the treatment of type 2 diabetes mellitus

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Emaad Ahmed ◽  
Zahir Abdulridha ◽  
Nick Hartmanis ◽  
Annette Gilchrist ◽  
Brian Layden ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
Fatty Acid Receptor

Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus

2020 ◽  
Vol 20 ◽  
Author(s):  
Lata Rani ◽  
Ajmer Singh Grewal ◽  
Neelam Sharma ◽  
Sukhbir Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acid Receptor ◽  
Clinical Investigations ◽  
Free Fatty Acid Receptor ◽  
Fatty Acid Receptor

Background: The disturbing incidence of type 2 diabetes mellitus (T2DM) enthused the development of newer antidiabetic targets with low toxicity and longer stability. In this respect, free fatty acid receptor 1 (FFAR1), also recognized as G protein-coupled receptor 40 (GPR40) is novel target for the treatment of T2DM. FFAR1/GPR40 have high level of expression in β-cells of pancreas and requirement of glucose for stimulating insulin release results in immense stimulation to utilise these targets in the medication of T2DM. Methods: Data used for this review was based on search from several science databases as well as various patent databases. The main data search terms used were free fatty acid receptor 1, FFAR1, FFAR1 agonists, diabetes mellitus, G protein coupled receptor 40 (GPR40), GPR40 agonists, GPR40 ligands, type 2 diabetes mellitus and T2DM. Results: The present review article gives a brief overview of FFAR1, role in T2DM, recent developments in small molecule FFAR1 (GPR40) agonists reported till now, compounds of natural/plant origin, recent patents published in last few years, mechanism of FFAR1 activation by the agonists, and clinical status of the FFAR1/GPR40 agonists. Conclusion: The agonists of FFAR1/GRP40 showed considerable potential for the therapeutic control of T2DM. Most of the small molecule FFAR1/GPR40 agonists developed were aryl alkanoic acid derivatives (such as phenylpropionic acids, phenylacetic acids, phenoxyacetic acids and benzofuran acetic acid derivatives) and thiazolidinediones. Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists. The clinical investigations of the FFAR1 agonists had demonstrated their probable role in the improvement of glucose control. Though, there are some problems still to be resolved in this field since some FFAR1 agonists terminated in late phase of clinical studies due to “hepatotoxicity”. Currently, PBI-4050 is under clinical investigation by Prometic. Furthermore, the more investigation of pharmacophore scaffolds for FFAR1 full agonists as well as multi-targeted modulators and corresponding clinical investigations will be anticipated which could open up new directions in this area.

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