Cremaster muscle is not sexually dimorphic, but that from boys with undescended testis reflects alterations related to autonomic innervation

2001 ◽  
Vol 36 (6) ◽  
pp. 877-880 ◽  
Author(s):  
F.Cahit Tanyel ◽  
Sevim Erdem ◽  
Nebil Büyükpamukçu ◽  
Ersin Tan
Keyword(s):  
Undescended Testis ◽  
Autonomic Innervation ◽  
Sexually Dimorphic ◽  
Cremaster Muscle

scholarly journals Role of ADAMTS16 metalloproteinase in pathogenesis of cryptorchidism

2020 ◽  
Author(s):  
Joanna Gerszon ◽  
Jacek Kabziński ◽  
Piotr Kucharski ◽  
Ireneusz Majsterek ◽  
Jerzy K. Niedzielski
Keyword(s):  
Undescended Testis ◽  
Reference Group ◽  
Cremaster Muscle ◽  
Tissue Samples ◽  
Hernial Sac ◽  
Age Related ◽  
Increased Risk ◽  
Testis Descent ◽  
Lower Expression

IntroductionThe etiology of cryptorchidism is still not fully elucidated, but several hypotheses have been proposed. One of the latest concerns is the involvement of metalloproteinase ADAMTS16 in testis descent. The aim of this study was to evaluate both expression and occurrence of selected polymorphisms of metalloproteinase ADAMTS16 in patients diagnosed with cryptorchidism.Material and methodsThe study group consisted of 158 boys (mean age: 4.1 ±2.04 years) who underwent surgery due to undescended testis. Tissue samples from patients with cryptorchidism were obtained from the cremaster muscle, gubernaculum and hernial sac. The reference group consisted of 123 age-related subjects (mean age: 4.1 ±2.41 years) who had no cryptorchidism and underwent surgery for other reasons. Tissue samples from controls were obtained from the cremaster muscle and hernial sac.ResultsThe obtained data indicate that patients with undescended testis have significantly lower expression of Adamts16, especially in the gubernaculum. We also demonstrated a tendency that Adamts16 expression depends on the age of patients; the older the patient was, the higher was the observed expression of Adamts16. These studies also established that polymorphisms rs16875319, rs16875122, and rs58353460 in the Adamts16 gene are not a major determinant to develop cryptorchidism while rs16875054 is associated with increased risk.ConclusionsThese studies highlight ADAMTS16 involvement in cryptorchidism and confirm data obtained in animal models.

scholarly journals Detection of insulin-like growth factor receptor-1 in the human cremaster muscle and its role in the etiology of the undescended testis

2019 ◽  
Vol 42 (1) ◽  
pp. 290-296 ◽  
Author(s):  
Mustafa Yaşar Özdamar ◽  
Sevinç Şahin ◽  
Kürşad Zengin ◽  
Selda Seçkin ◽  
Mesut Gürdal
Keyword(s):  
Growth Factor ◽  
Undescended Testis ◽  
Growth Factor Receptor ◽  
Insulin Like Growth Factor ◽  
Cremaster Muscle

Ultrastructural deficiency in autonomic innervation in cremasteric muscle of boys with undescended testis

2001 ◽  
Vol 36 (4) ◽  
pp. 573-578 ◽  
Author(s):  
F.Cahit Tanyel ◽  
Sevda Müftüoğlu ◽  
Attila Dağdeviren ◽  
Lale Karakoç ◽  
Nebil Büyükpamukçu
Keyword(s):  
Undescended Testis ◽  
Autonomic Innervation ◽  
Cremasteric Muscle

Androgen-induced plasticity at a “vocal” neuromuscular synapse

1994 ◽  
Vol 52 ◽  
pp. 32-33
Author(s):  
Darcy B. Kelley ◽  
Martha L. Tobias ◽  
Mark Ellisman
Keyword(s):  
Xenopus Laevis ◽  
Motor Neurons ◽  
Sexual Differentiation ◽  
Molecular Basis ◽  
Neuromuscular Synapse ◽  
Sexually Dimorphic ◽  
Intracellular Protein ◽  
Developmental Program ◽  
Androgen Action ◽  
Clawed Frog

Brain and muscle are sexually differentiated tissues in which masculinization is controlled by the secretion of androgens from the testes. Sensitivity to androgen is conferred by the expression of an intracellular protein, the androgen receptor. A central problem of sexual differentiation is thus to understand the cellular and molecular basis of androgen action. We do not understand how hormone occupancy of a receptor translates into an alteration in the developmental program of the target cell. Our studies on sexual differentiation of brain and muscle in Xenopus laevis are designed to explore the molecular basis of androgen induced sexual differentiation by examining how this hormone controls the masculinization of brain and muscle targets.Our approach to this problem has focused on a highly androgen sensitive, sexually dimorphic neuromuscular system: laryngeal muscles and motor neurons of the clawed frog, Xenopus laevis. We have been studying sex differences at a synapse, the laryngeal neuromuscular junction, which mediates sexually dimorphic vocal behavior in Xenopus laevis frogs.

The Relationship of Digit Ratio (2D:4D) and Gender-Role Orientation in Four National Samples

2007 ◽  
Vol 28 (2) ◽  
pp. 78-87 ◽  
Author(s):  
Stefan J. Troche ◽  
Nina Weber ◽  
Karina Hennigs ◽  
Carl-René Andresen ◽  
Thomas H. Rammsayer
Keyword(s):  
Gender Role ◽  
Sex Role ◽  
Role Orientation ◽  
Sexually Dimorphic ◽  
Gender Role Orientation ◽  
Left Hand ◽  
Fourth Finger ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship

Abstract. The ratio of second to fourth finger length (2D:4D ratio) is sexually dimorphic with women having higher 2D:4D ratio than men. Recent studies on the relationship between 2D:4D ratio and gender-role orientation yielded rather inconsistent results. The present study examines the moderating influence of nationality on the relationship between 2D:4D ratio and gender-role orientation, as assessed with the Bem Sex-Role Inventory, as a possible explanation for these inconsistencies. Participants were 176 female and 171 male university students from Germany, Italy, Spain, and Sweden ranging in age from 19 to 32 years. Left-hand 2D:4D ratio was significantly lower in men than in women across all nationalities. Right-hand 2D:4D ratio differed only between Swedish males and females indicating that nationality might effectively moderate the sexual dimorphism of 2D:4D ratio. In none of the examined nationalities was a reliable relationship between 2D:4D ratio and gender-role orientation obtained. Thus, the assumption of nationality-related between-population differences does not seem to account for the inconsistent results on the relationship between 2D:4D ratio and gender-role orientation.

Chemogenetic inhibition of dopaminergic projections to the nucleus accumbens has sexually dimorphic effects in the rat gambling task.

2020 ◽  
Vol 134 (4) ◽  
pp. 309-322 ◽  
Author(s):  
Tristan J. Hynes ◽  
Jacqueline-Marie M. Ferland ◽  
Tanya L. Feng ◽  
Wendy K. Adams ◽  
Mason M. Silveira ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Sexually Dimorphic ◽  
Gambling Task

PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

2018 ◽  
Author(s):  
Dumontet T ◽  
Sahut-Barnola I ◽  
Septier A ◽  
Montanier N ◽  
Plotton I ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Sexually Dimorphic
Sign in / Sign up

Export Citation Format

Share Document