scholarly journals Effect of articular cartilage proteoglycan depletion on high frequency ultrasound backscatter

2002 ◽  
Vol 10 (7) ◽  
pp. 535-541 ◽  
Author(s):  
B. Pellaumail ◽  
A. Watrin ◽  
D. Loeuille ◽  
P. Netter ◽  
G. Berger ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
High Frequency ◽  
High Frequency Ultrasound ◽  
Cartilage Proteoglycan ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound

3-D High-Frequency Ultrasound Backscatter Analysis of Human Articular Cartilage

2014 ◽  
Vol 40 (1) ◽  
pp. 244-257 ◽  
Author(s):  
Nils Männicke ◽  
Martin Schöne ◽  
Matthias Gottwald ◽  
Felix Göbel ◽  
Michael L. Oelze ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
High Frequency ◽  
Human Articular Cartilage ◽  
High Frequency Ultrasound ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound

scholarly journals Towards Understanding the Nature of High Frequency Ultrasound Backscatter from Cells and Tissues: an Investigation of Backscatter Power Spectra from Different Concentrations of Cells of Different Sizes

2021 ◽  
Author(s):  
Michael C. Kolios ◽  
G. J. Czarnota ◽  
A. E. Worthington ◽  
A. Giles ◽  
A. S. Tunis ◽  
...  
Keyword(s):  
High Frequency ◽  
Power Spectra ◽  
High Frequency Ultrasound ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound

Towards Understanding the Nature of High Frequency Ultrasound Backscatter from Cells and Tissues: an Investigation of Backscatter Power Spectra from Different Concentrations of Cells of Different Sizes

Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage

2016 ◽  
Vol 42 (6) ◽  
pp. 1375-1384 ◽  
Author(s):  
Nils Männicke ◽  
Martin Schöne ◽  
Jukka Liukkonen ◽  
Dominik Fachet ◽  
Satu Inkinen ◽  
...  
Keyword(s):  
High Frequency ◽  
Hyaline Cartilage ◽  
High Frequency Ultrasound ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound

Extraction of Mechanical Properties of Articular Cartilage From Osmotic Swelling Behavior Monitored Using High Frequency Ultrasound

2006 ◽  
Vol 129 (3) ◽  
pp. 413-422 ◽  
Author(s):  
Q. Wang ◽  
Y. P. Zheng ◽  
H. J. Niu ◽  
A. F. T. Mak
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
High Frequency ◽  
Weight Bearing ◽  
Ultrasound Measurement ◽  
High Frequency Ultrasound ◽  
Water Fraction ◽  
Layer Interface ◽  
Osmotic Loading ◽  
Frequency Ultrasound

Articular cartilage is a biological weight-bearing tissue covering the bony ends of articulating joints. Negatively charged proteoglycan (PG) in articular cartilage is one of the main factors that govern its compressive mechanical behavior and swelling phenomenon. PG is nonuniformly distributed throughout the depth direction, and its amount or distribution may change in the degenerated articular cartilage such as osteoarthritis. In this paper, we used a 50MHz ultrasound system to study the depth-dependent strain of articular cartilage under the osmotic loading induced by the decrease of the bathing saline concentration. The swelling-induced strains under the osmotic loading were used to determine the layered material properties of articular cartilage based on a triphasic model of the free-swelling. Fourteen cylindrical cartilage-bone samples prepared from fresh normal bovine patellae were tested in situ in this study. A layered triphasic model was proposed to describe the depth distribution of the swelling strain for the cartilage and to determine its aggregate modulus Ha at two different layers, within which Ha was assumed to be linearly dependent on the depth. The results showed that Ha was 3.0±3.2, 7.0±7.4, 24.5±11.1MPa at the cartilage surface, layer interface, and deep region, respectively. They are significantly different (p<0.01). The layer interface located at 70%±20% of the overall thickness from the uncalcified-calcified cartilage interface. Parametric analysis demonstrated that the depth-dependent distribution of the water fraction had a significant effect on the modeling results but not the fixed charge density. This study showed that high-frequency ultrasound measurement together with triphasic modeling is practical for quantifying the layered mechanical properties of articular cartilage nondestructively and has the potential for providing useful information for the detection of the early signs of osteoarthritis.

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