scholarly journals More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise

2001 ◽  
Vol 9 (2) ◽  
pp. 152-160 ◽  
Author(s):  
T. Lapveteläinen ◽  
M. Hyttinen ◽  
J. Lindblom ◽  
T.K. Långsjö ◽  
R. Sironen ◽  
...  
Keyword(s):  
Knee Joint ◽  
Wheel Running ◽  
Type Ii ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

scholarly journals Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0130259 ◽  
Author(s):  
Thomas H. Reynolds ◽  
Sayani Banerjee ◽  
Vishva Mitra Sharma ◽  
Jacob Donohue ◽  
Sandrine Couldwell ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Wheel Running ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

scholarly journals PO-034 Effect of Voluntary Exercise on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wenhao Zong ◽  
Yang Liu ◽  
Lulu Dai ◽  
Guijun Dong
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
High Fat Diet ◽  
Wheel Running ◽  
Cartilage Thickness ◽  
Obese Mice ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

Objective To examine the effect of voluntary wheel-running exercise on cartilage morphology of knee osteoarthritis(KOA) in obese mice induced by high-fat diet,and explore the protective role of 4 weeks voluntary wheel-running exercise on KOA,finally providing effective experimental evidence for clinical treatment of knee osteoarthritis. Methods C57BL/6J mice were randomly assigned to the C-Sed group,C-Ex group,HF-Sed group and HF-Ex group.The control groups were fed a control diet(13.5% kcal from fat),and the high-fat groups were fed a high-fat diet(60% kcal from fat).After feeding 8 weeks different diets,the exercise groups were starting running.In order to examine the effect of voluntary wheel-running exercise on cartilage morphology of KOA,the joint of knee were harvested to be fixed,decalcified and embedded in paraffin,and the four-micrometer-thick sections were stained with both HE and toluidine blue . Results After feeding twelve weeks different diets,the body mass of the high-fat diet group mice has a significant increase,which demonstrates that high-fat diet could successfully induce the mice obese.From the results of HE and toluidine blue,in comparison to the C-Sed group,the surface of the knee articular cartilage in the HF-Sed group was not intact and smooth,and the thickness of articular cartilage has a significant decrease（p<0.001）;contrary to the HF-Sed group,the surface of the knee articular cartilage in HF-Ex group was slightly smooth,and there was significant increase in cartilage thickness. Conclusions Four weeks voluntary wheel-running exercise can increase cartilage thickness ,decrease the Mankin’s score and delay the degeneration of knee cartilage in obese mice.To conclude,the short-term wheel-running exercise protects against obesity-induced KOA.

scholarly journals Voluntary Wheel Running Exercise Improves Aging-Induced Sarcopenia via Activation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α/Fibronectin Type III Domain-Containing Protein 5/Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

2021 ◽  
Vol 25 (Suppl 1) ◽  
pp. S27-34 ◽  
Author(s):  
Young Jun Ko ◽  
Il-Gyu Ko
Keyword(s):  
Signaling Pathway ◽  
Wheel Running ◽  
Adenosine Monophosphate ◽  
Peroxisome Proliferator ◽  
Voluntary Wheel Running ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ampk Signaling ◽  
Running Exercise ◽  
Fibronectin Type Iii Domain ◽  
Voluntary Wheel

Purpose: In this study, the protective effect of voluntary wheel running exercise on muscle loss and muscle weakness in gastrocnemius of old rats was investigated. The association of voluntary wheel exercise with the peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α)/fibronectin type III domain-containing protein 5 (FNDC5)/adenosine monophosphate- activated protein kinase (AMPK) signaling pathway and vascular endothelial growth factor (VEGF) expression was also evaluated.Methods: Six-month-old and 22-month-old male rats were used for this experiment. The rats in voluntary wheel running exercise groups were performed wheel running for 2 months. Weight bearing test for walking strength, rotarod test for motor coordination and balance, hematoxylin and eosin (H&E) staining for histological changes in the muscle tissues, Western blot analysis for PGC-1α, FNDC5, AMPK, immunofluorescence for VEGF were conducted.Results: Decreased muscle mass, strength, and coordination due to aging were associated with a decrease in the PGC-1α/ FNDC5/AMPK signaling pathway in the gastrocnemius. Voluntary wheel running exercise enhanced VEGF expression by activating the PGC-1α/FNDC5/AMPK signaling pathway, then increased muscle mass, strength, and coordination.Conclusions: It has been suggested that voluntary wheel running exercise alleviates symptoms of urological diseases that are difficult to treat. Wheel running exercise is a good therapeutic strategy to prevent or treat aging-related sarcopenia.

Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces

2010 ◽  
Vol 109 (3) ◽  
pp. 663-668 ◽  
Author(s):  
Masahito Hagio ◽  
Megumi Matsumoto ◽  
Takaji Yajima ◽  
Hiroshi Hara ◽  
Satoshi Ishizuka
Keyword(s):  
Bile Acids ◽  
Large Intestine ◽  
Dietary Intervention ◽  
Wheel Running ◽  
Colorectal Carcinogenesis ◽  
Ionization Mass ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Secondary Bile Acids ◽  
Voluntary Wheel

According to epidemiologic studies, a negative correlation exists between exercise amount and subsequent cancer development risk in the large intestine. The proportion of secondary bile acids (SBA) in the large intestine is related to subsequent risk for colorectal carcinogenesis. The aim of this study was to investigate the effects of voluntary wheel running exercise and dietary intervention on bile acid (BA) metabolism in the large intestine. Wistar/ST rats (6 wk old) were divided into two groups, exercise and sedentary, after acclimation. Four days after the animals were assigned to a group, rats in each group were fed diets supplemented with different carbohydrate sources including dextrin, sucrose, and lactose. The wheel running period was 4 wk in the exercise group, whereas rats in the sedentary group remained in individual cages during this period. BA composition in collected feces was analyzed with ultraperformance liquid chromatography-electrospray ionization mass spectrometry. We found that wheel running exercise decreased plasma concentrations of cholesterol, triglyceride, and free fatty acids. These decreases were accompanied by a reduction in the proportion of SBA to primary BA (PBA) in feces; however, daily excretion of BA was comparable regardless of wheel running exercise. In addition, ingestion of lactose decreased the SBA-to-PBA ratio and suppressed production of hyodeoxycholic acid in feces. In conclusion, voluntary wheel running exercise, in combination with dietary intervention, could independently reduce the SBA-to-PBA ratio within the large intestine without changing BA excretion. These changes may contribute to the prevention of colorectal carcinogenesis.

scholarly journals Metabolic Adaptations of Skeletal Muscle to Voluntary Wheel Running Exercise in Hypertensive Heart Failure Rats

2013 ◽  
pp. 361-369 ◽  
Author(s):  
R. L. SCHULTZ ◽  
E. L. KULLMAN ◽  
R. P. WATERS ◽  
H. HUANG ◽  
J. P. KIRWAN ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Citrate Synthase ◽  
Wheel Running ◽  
Heart Function ◽  
Oxidative Capacity ◽  
Voluntary Wheel Running ◽  
Spontaneously Hypertensive ◽  
Running Exercise ◽  
Voluntary Wheel

The Spontaneously Hypertensive Heart Failure (SHHF) rat mimics the human progression of hypertension from hypertrophy to heart failure. However, it is unknown whether SHHF animals can exercise at sufficient levels to observe beneficial biochemical adaptations in skeletal muscle. Thirty-seven female SHHF and Wistar-Furth (WF) rats were randomized to sedentary (SHHFsed and WFsed) and exercise groups (SHHFex and WFex). The exercise groups had access to running wheels from 6-22 months of age. Hindlimb muscles were obtained for metabolic measures that included mitochondrial enzyme function and expression, and glycogen utilization. The SHHFex rats ran a greater distance and duration as compared to the WFex rats (P<0.05), but the WFex rats ran at a faster speed (P<0.05). Skeletal muscle citrate synthase and β-hydroxyacyl-CoA dehydrogenase enzyme activity was not altered in the SHHFex group, but was increased (P<0.05) in the WFex animals. Citrate synthase protein and gene expression were unchanged in SHHFex animals, but were increased in WFex rats (P<0.05). In the WFex animals muscle glycogen was significantly depleted after exercise (P<0.05), but not in the SHHFex group. We conclude that despite robust amounts of aerobic activity, voluntary wheel running exercise was not sufficiently intense to improve the oxidative capacity of skeletal muscle in adult SHHF animals, indicating an inability to compensate for declining heart function by improving peripheral oxidative adaptations in the skeletal muscle.

Effect of voluntary wheel-running exercise on muscles of the mdx mouse

1995 ◽  
Vol 5 (4) ◽  
pp. 323-332 ◽  
Author(s):  
Gregory T. Carter ◽  
Mark A. Wineinger ◽  
Sandra A. Walsh ◽  
Sylvia J. Horasek ◽  
Richard T. Abresch ◽  
...  
Keyword(s):  
Wheel Running ◽  
Mdx Mouse ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel
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