scholarly journals Basic calcium phosphate crystal-induced collagenase production: role of intracellular crystal dissolution

1998 ◽  
Vol 6 (3) ◽  
pp. 205-213 ◽  
Author(s):  
Geraldine M. McCarthy ◽  
Herman S. Cheung ◽  
Susan M. Abel ◽  
Lawrence M. Ryan
Keyword(s):  
Calcium Phosphate ◽  
Basic Calcium Phosphate ◽  
Crystal Dissolution ◽  
Calcium Phosphate Crystal ◽  
Basic Calcium Phosphate Crystal

Osteoarthritis, a basic calcium phosphate crystal-associated arthropathy? Comment on the article by Fuerst et al

2010 ◽  
Vol 62 (9) ◽  
pp. 2829-2830 ◽  
Author(s):  
Christelle Nguyen ◽  
Hang-Korng Ea ◽  
Dominique Bazin ◽  
Michel Daudon ◽  
Frédéric Lioté
Keyword(s):  
Calcium Phosphate ◽  
Basic Calcium Phosphate ◽  
Calcium Phosphate Crystal ◽  
Basic Calcium Phosphate Crystal

Basic calcium phosphate crystal deposition

2016 ◽  
Author(s):  
Nicola Dalbeth
Keyword(s):  
Calcium Phosphate ◽  
Basic Calcium Phosphate ◽  
Crystal Deposition ◽  
Joint Tissue ◽  
Crystal Dissolution ◽  
Clinical Syndromes ◽  
Clinical Presentations ◽  
Tissue Responses ◽  
Shoulder Syndrome ◽  
Basic Calcium Phosphate Crystal

Basic calcium phosphate (BCP) crystals deposit within periarticular and articular sites, leading to a variety of clinical presentations. The most well-recognized clinical syndromes associated with BCP crystal deposition are calcific tendinitis and BCP crystal-associated destructive arthritis such as Milwaukee shoulder syndrome. There is emerging evidence that BCP crystals also play a role in osteoarthritis pathogenesis. Within the joint, tissue responses to BCP crystals include induction of pro-catabolic and inflammatory pathways. Clinical management of BCP crystal-associated arthropathies is limited by the lack of reliable and feasible methods to detect crystals, and the current unavailability of systemic therapies that promote BCP crystal dissolution.

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