scholarly journals Effects of diacerhein on granuloma induced cartilage breakdown in the mouse

1998 ◽  
Vol 6 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Adrian R. Moore ◽  
Kevin J. Greenslade ◽  
Chandan A.S. Alam ◽  
Derek A. Willoughby
Keyword(s):  
Cartilage Breakdown

Intra-articular hyaluronic acid increases cartilage breakdown biomarker in patients with knee osteoarthritis

2010 ◽  
Vol 29 (6) ◽  
pp. 619-624 ◽  
Author(s):  
Alexandra M. Gonzalez-Fuentes ◽  
David M. Green ◽  
Roger D. Rossen ◽  
Bernard Ng
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Cartilage Breakdown

Effects of disease and dexamethasone on human cartilage breakdown kinetics

2021 ◽  
Vol 29 ◽  
pp. S153-S154
Author(s):  
R.M. Black ◽  
Y. Wang ◽  
P. Lorenzo ◽  
S. Chubinskaya ◽  
A.J. Grodzinsky ◽  
...  
Keyword(s):  
Human Cartilage ◽  
Cartilage Breakdown

scholarly journals New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 637 ◽  
Author(s):  
Paula Carpintero-Fernandez ◽  
Marta Varela-Eirin ◽  
Alessandra Lacetera ◽  
Raquel Gago-Fuentes ◽  
Eduardo Fonseca ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Ex Vivo ◽  
Molecular Model ◽  
Cartilage Degradation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Novel Therapy ◽  
Human Cartilage ◽  
Sialic Acid Receptors ◽  
Cartilage Breakdown

Osteoarthritis (OA) is the most common degenerative joint disease characterized by articular cartilage degradation and joint degeneration. The articular cartilage is mainly formed by chondrocytes and a collagen-proteoglycan extracellular matrix that contains high levels of glycosylated proteins. It was reported that the shift from glycoproteins containing α-2,6-linked sialic acids to those that contain α-2,3 was associated with the onset of common types of arthritis. However, the pathophysiology of α-2,3-sialylation in cartilage has not been yet elucidated. We show that cartilage from osteoarthritic patients expresses high levels of the α-2,3-sialylated transmembrane mucin receptor, known as podoplanin (PDPN). Additionally, the Maackia amurensis seed lectin (MASL), that can be utilized to target PDPN, attenuates the inflammatory response mediated by NF-kB activation in primary chondrocytes and protects human cartilage breakdown ex vivo and in an animal model of arthritis. These findings reveal that specific lectins targeting α-2,3-sialylated receptors on chondrocytes might effectively inhibit cartilage breakdown. We also present a computational 3D molecular model for this interaction. These findings provide mechanistic information on how a specific lectin could be used as a novel therapy to treat degenerative joint diseases such as osteoarthritis.

scholarly journals Cartilage breakdown by synovium-derived proteolytic enzymes

2002 ◽  
Vol 79 (5) ◽  
pp. A46-A46
Author(s):  
M. VANKEMMELBEKE ◽  
S. WANG-WEIGAND ◽  
D.J. BUTTLE
Keyword(s):  
Proteolytic Enzymes ◽  
Cartilage Breakdown

Cartilage breakdown in equine osteoarthritis: measurement of keratan sulphate by an elisa system

1990 ◽  
Vol 49 (1) ◽  
pp. 56-60 ◽  
Author(s):  
W.H. ALWAN ◽  
S.D. CARTER ◽  
D. BENNETT ◽  
S.A. MAY ◽  
G.B. EDWARDS
Keyword(s):  
Keratan Sulphate ◽  
Elisa System ◽  
Cartilage Breakdown ◽  
Equine Osteoarthritis

scholarly journals LIN28A protects against cartilage breakdown and osteoarthritis through the regulation of LET7/HMGA2 axis

2020 ◽  
Vol 28 ◽  
pp. S45
Author(s):  
Y. Jouan ◽  
B. Bardèche-Trystram ◽  
J. Sanna ◽  
H.-K. Ea ◽  
M. Cohen-Solal ◽  
...  
Keyword(s):  
Cartilage Breakdown

Inhibition of cartilage breakdown by isothiazolones

1993 ◽  
Vol 3 (12) ◽  
pp. 2875-2878 ◽  
Author(s):  
Stephen W. Wright ◽  
Joseph J. Petraitis ◽  
Matthew M. Abelman ◽  
Lori L. Bostrom ◽  
Ronald L. Corbett ◽  
...  
Keyword(s):  
Cartilage Breakdown
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