Epidemiological characterization of hospital-acquired Acinetobacter baumannii isolates from a 1500-bed teaching hospital by phenotypic and genotypic methods

2001 ◽  
Vol 47 (3) ◽  
pp. 246-247 ◽  
Author(s):  
A.C. Basustaoglu ◽  
O. Kisa ◽  
S.C. Sacilik ◽  
M. Ozyurt ◽  
S.T. Yildiran
Keyword(s):  
Acinetobacter Baumannii ◽  
Teaching Hospital ◽  
Hospital Acquired ◽  
Epidemiological Characterization

scholarly journals Characterization of carbapenem-resistant Acinetobacter baumannii isolates in a Chinese teaching hospital

2015 ◽  
Vol 6 ◽  
Author(s):  
Yaowen Chang ◽  
Guangxin Luan ◽  
Ying Xu ◽  
Yanhong Wang ◽  
Min Shen ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Teaching Hospital ◽  
Carbapenem Resistant ◽  
Chinese Teaching

Epidemiological characterization of Acinetobacter baumannii bloodstream isolates from a Chinese Burn Institute: A three-year study

Burns ◽  
2016 ◽  
Vol 42 (7) ◽  
pp. 1542-1547 ◽  
Author(s):  
Guangtao Huang ◽  
Supeng Yin ◽  
Lijuan Xiang ◽  
Yali Gong ◽  
Kedai Sun ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Epidemiological Characterization

scholarly journals Resistance and integron characterization of Acinetobacter baumannii in a teaching hospital in Chongqing, China

2015 ◽  
Vol 8 ◽  
pp. 103-108 ◽  
Author(s):  
C. Huang ◽  
Q. Long ◽  
K. Qian ◽  
T. Fu ◽  
Z. Zhang ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Teaching Hospital

scholarly journals Glycosphingolipids Recognized by Acinetobacter baumannii

2020 ◽  
Vol 8 (4) ◽  
pp. 612
Author(s):  
Miralda Madar Johansson ◽  
Mehjar Azzouz ◽  
Beatrice Häggendal ◽  
Karin Säljö ◽  
Henri Malmi ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Bacterial Pathogen ◽  
Basic Element ◽  
Target Tissue ◽  
Binding Assays ◽  
Isolation And Characterization ◽  
Rabbit Small Intestine ◽  
Host Cell Surface ◽  
Hospital Acquired

Acinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections, including pneumonia, meningitis, bacteremia, urinary tract infection, and wound infections. Recognition of host cell surface carbohydrates plays a crucial role in adhesion and enables microbes to colonize different host niches. Here the potential glycosphingolipid receptors of A. baumannii were examined by binding of 35S-labeled bacteria to glycosphingolipids on thin-layer chromatograms. Thereby a selective interaction with two non-acid glycosphingolipids of human and rabbit small intestine was found. The binding-active glycosphingolipids were isolated and, on the basis of mass spectrometry, identified as neolactotetraosylceramide (Galβ4GlcNAcβ3Galβ4Glcβ1Cer) and lactotetraosylceramide (Galβ3GlcNAcβ3Galβ4Glcβ1Cer). Further binding assays using reference glycosphingolipids showed that A. baumannii also bound to lactotriaosylceramide (GlcNAcβ3Galβ4Glcβ1Cer) demonstrating that GlcNAc was the basic element recognized. In addition, the bacteria occasionally bound to galactosylceramide, lactosylceramide with phytosphingosine and/or hydroxy fatty acids, isoglobotriaosylceramide, gangliotriaosylceramide, and gangliotetraosylceramide, in analogy with binding patterns that previously have been described for other bacteria classified as “lactosylceramide-binding”. Finally, by isolation and characterization of glycosphingolipids from human skin, the presence of neolactotetraosylceramide was demonstrated in this A. baumannii target tissue.

scholarly journals Molecular Characterization of Multiple Antibiotic-Resistant Acinetobacter baumannii Isolated from Egyptian Patients

2020 ◽  
Vol 14 (4) ◽  
pp. 2399-2405
Author(s):  
Aya A. Khodier ◽  
Amal Saafan ◽  
Walid Bakeer ◽  
Ahmed S. Khairalla
Keyword(s):  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Class I ◽  
Pcr Analysis ◽  
Antibiotic Resistant ◽  
Egyptian Patients ◽  
Class I Integrons ◽  
Genetic Mechanisms ◽  
Hospital Acquired

Acinetobacter baumannii is an opportunistic microorganism commonly found in intensive care units (ICUs), and it is responsible for a broad span of hospital-acquired infections. Persistence of nosocomial infection caused by multidrug-resistant (MDR) A. baumannii is an alarming health care issue in Egypt, and at present, colistin remains the treatment of choice for the management of MDR A. baumannii infections. A. baumannii possesses great capacity to develop and acquire resistance to a broad range of antibiotics. The acquisition and dissemination of antibiotic-resistant determinants in A. baumannii strains are mediated by integrons, especially class I integrons. This study focuses on the characterization of some genetic mechanisms underlying the multidrug-resistant phenotypes of A. baumannii isolates in Egypt. Forty-eight A. baumannii specimens were isolated from different hospitalized patients; least resistance was observed against amikacin and tigecycline, with 60% and 58.5% of the isolates resistant, respectively, whereas 62.5% of the isolates were resistant to imipenem and meropenem. The highest sensitivity was found for colistin. Genetic analysis revealed that blaoxa-51 was detected in all isolates, the blaoxa-23-like gene was detected in 80% of the isolates, and blaoxa-24 and blaoxs-58 were not detected in any isolate. Finally, PCR analysis revealed that 6.6% of isolates carried the class I integron gene.

scholarly journals Characterization of hospital acquired infections in teritaty care teaching hospital, Kathmandu

2020 ◽  
Vol 101 ◽  
pp. 281
Author(s):  
B.P. Rijal ◽  
S. Maharjan ◽  
N. Giri ◽  
O. Shrestha ◽  
S. Shrestha ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Care Teaching ◽  
Hospital Acquired Infections ◽  
Hospital Acquired

scholarly journals Epidemiological Study of Hospital-Acquired Bacterial Conjunctivitis in a Level III Neonatal Unit

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Catarina Dias ◽  
Márcia Gonçalves ◽  
Anabela João
Keyword(s):  
Neonatal Unit ◽  
Bacterial Conjunctivitis ◽  
Life Threatening ◽  
Local Patterns ◽  
Hospital Acquired ◽  
Epidemiological Characterization ◽  
Epidemiologic Characteristics ◽  
Susceptibility Patterns ◽  
Bacterial Resistances

Background. Conjunctivitis is one of the most frequently occurring hospital-acquired infections among neonates, although it is less studied than potentially life-threatening infections, such as sepsis and pneumonia.Objectives. The aims of our work were to identify epidemiologic characteristics, pathogens, and susceptibility patterns of bacterial hospital-acquired conjunctivitis (HAC) in a level III neonatal unit.Materials and Methods. Data were collected retrospectively from patient charts and laboratory databases. Hospital-acquired conjunctivitis was defined in accordance with the Centers for Disease Control/National Healthcare Safety Network (CDC/NHSN) diagnostic criteria.Results. One or more episodes of HAC were diagnosed in 4,0% () of 1492 neonates admitted during the study period. Most of the episodes involved premature (75,4%) and low birth weight (75,4%) neonates. Infection rates were higher among patients undergoing noninvasive mechanical ventilation (46,7%), parenteral nutrition (13,6%), and phototherapy (6,8%). Predominant pathogens includedSerratia marcescens(27,9%),Escherichia coli(23%), andPseudomonas aeruginosa(18%). Susceptibility patterns revealed bacterial resistances to several antibiotic classes. Gentamicin remains the adequate choice for empirical treatment of HAC in our NICU.Conclusion. It is important to know the local patterns of the disease in order to adjust prevention strategies. Our work contributes to the epidemiological characterization of a sometimes overlooked disease.

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