scholarly journals Immunologic Considerations for Therapeutic Strategies Utilizing Allogeneic Hepatocytes: Hepatocyte-Expressed Membrane-Bound Major Histocompatibility Complex Class I Antigen Sensitizes While Soluble Antigen Suppresses the Immune Response in Rats

Hepatology ◽  
2000 ◽  
Vol 32 (5) ◽  
pp. 999-1007 ◽  
Author(s):  
M Scherer
Keyword(s):  
Immune Response ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Therapeutic Strategies ◽  
Class I ◽  
Soluble Antigen ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Membrane Bound

scholarly journals Downregulation of major histocompatibility complex class I in bovine papillomas

2004 ◽  
Vol 85 (10) ◽  
pp. 2809-2814 ◽  
Author(s):  
E. H. Araibi ◽  
B. Marchetti ◽  
G. H. Ashrafi ◽  
M. S. Campo
Keyword(s):  
Immune Response ◽  
Major Histocompatibility Complex ◽  
Immune System ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Host Immune System ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Mhc I ◽  
Histocompatibility Complex

Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy. Even in the absence of malignant transformation, BPV infection persists for a significant period of time before activation of the host immune system, suggesting that the host immune system is unaware of, or disabled by, BPV. E5 is the major oncoprotein of BPV, which, in addition to its transforming properties, downregulates the expression and transport to the cell surface of major histocompatibility complex class I (MHC I). Here, it is shown that co-expression of MHC I and E5 in papillomas caused by BPV-4 infection is mutually exclusive, in agreement with the inhibition of surface MHC I expression by E5 that is observed in vitro. The inhibition of MHC expression in E5-expressing papilloma cells could explain the long period that is required for activation of the immune response and has implications for the progression of papillomas to the malignant stage; absence of peptide presentation by MHC I to cytotoxic T lymphocytes would allow the infected cells to evade the host cellular immune response and allow the lesions to persist.

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