scholarly journals A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery

2020 ◽  
Vol 34 (2) ◽  
pp. 409-416 ◽  
Author(s):  
Fumitaka Yanase ◽  
Laurent Bitker ◽  
Lara Hessels ◽  
Eduardo Osawa ◽  
Thummaporn Naorungroj ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Vitamin C ◽  
Controlled Trial ◽  
High Dose ◽  
Double Blind ◽  
Randomized Controlled ◽  
Intravenous Vitamin

scholarly journals Intravenous Vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial

2012 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang-Yeon Suh ◽  
Woo Kyung Bae ◽  
Hong-Yup Ahn ◽  
Sung-Eun Choi ◽  
Gyou-Chul Jung ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Vitamin C ◽  
Controlled Trial ◽  
Office Workers ◽  
Double Blind ◽  
Randomized Controlled ◽  
Intravenous Vitamin

scholarly journals Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Marie-Hélène Masse ◽  
◽  
Julie Ménard ◽  
Sheila Sprague ◽  
Marie-Claude Battista ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Vitamin C ◽  
Organ Dysfunction ◽  
Controlled Trial ◽  
Invasive Mechanical Ventilation ◽  
Kidney Injury ◽  
Composite Endpoint ◽  
High Dose ◽  
Randomized Controlled ◽  
Intravenous Vitamin

Abstract Background Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis. Methods LOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800). Eligible patients have sepsis as the diagnosis for admission to the intensive care unit (ICU) and are receiving vasopressors. Those admitted to the ICU for more than 24 h are excluded. Eligible patients are randomized to high-dose intravenous vitamin C (50 mg/kg every 6 h for 96 h) or placebo. The primary outcome is a composite of death or persistent organ dysfunction (need for vasopressors, invasive mechanical ventilation, or new and persisting renal replacement therapy) at day 28. Secondary outcomes include persistent organ dysfunction-free days to day 28, mortality and health-related quality of life at 6 months, biomarkers of dysoxia, inflammation, infection, endothelial function, and adverse effects (hemolysis, acute kidney injury, and hypoglycemia). Six subgroup analyses are planned. Discussion This RCT will provide evidence of the effect of high-dose intravenous vitamin C on patient-important outcomes in patients with sepsis. Trial registration clinicaltrials.gov, NCT03680274, first posted 21 September 2018.

scholarly journals A pilot double‐blind safety and feasibility randomized controlled trial of high‐dose intravenous zinc in hospitalized COVID‐19 patients

2021 ◽  
Vol 93 (5) ◽  
pp. 3261-3267 ◽  
Author(s):  
Oneel Patel ◽  
Vidyasagar Chinni ◽  
John El‐Khoury ◽  
Marlon Perera ◽  
Ary S. Neto ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
High Dose ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sander Rozemeijer ◽  
Harm-Jan de Grooth ◽  
Paul W. G. Elbers ◽  
Armand R. J. Girbes ◽  
Corstiaan A. den Uil ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Vitamin C ◽  
Organ Failure ◽  
Controlled Trial ◽  
Lung Injury Score ◽  
High Dose ◽  
Double Blind ◽  
Link Type ◽  
Search Trial ◽  
Intravenous Vitamin

Abstract Background High-dose intravenous vitamin C directly scavenges and decreases the production of harmful reactive oxygen species (ROS) generated during ischemia/reperfusion after a cardiac arrest. The aim of this study is to investigate whether short-term treatment with a supplementary or very high-dose intravenous vitamin C reduces organ failure in post-cardiac arrest patients. Methods This is a double-blind, multi-center, randomized placebo-controlled trial conducted in 7 intensive care units (ICUs) in The Netherlands. A total of 270 patients with cardiac arrest and return of spontaneous circulation will be randomly assigned to three groups of 90 patients (1:1:1 ratio, stratified by site and age). Patients will intravenously receive a placebo, a supplementation dose of 3 g of vitamin C or a pharmacological dose of 10 g of vitamin C per day for 96 h. The primary endpoint is organ failure at 96 h as measured by the Resuscitation-Sequential Organ Failure Assessment (R-SOFA) score at 96 h minus the baseline score (delta R-SOFA). Secondary endpoints are a neurological outcome, mortality, length of ICU and hospital stay, myocardial injury, vasopressor support, lung injury score, ventilator-free days, renal function, ICU-acquired weakness, delirium, oxidative stress parameters, and plasma vitamin C concentrations. Discussion Vitamin C supplementation is safe and preclinical studies have shown beneficial effects of high-dose IV vitamin C in cardiac arrest models. This is the first RCT to assess the clinical effect of intravenous vitamin C on organ dysfunction in critically ill patients after cardiac arrest. Trial registration ClinicalTrials.gov NCT03509662. Registered on April 26, 2018. https://clinicaltrials.gov/ct2/show/NCT03509662European Clinical Trials Database (EudraCT): 2017-004318-25. Registered on June 8, 2018. https://www.clinicaltrialsregister.eu/ctr-search/trial/2017-004318-25/NL

Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: A pilot double-blind, randomized controlled trial*

2009 ◽  
Vol 37 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Michael Haase ◽  
Anja Haase-Fielitz ◽  
Rinaldo Bellomo ◽  
Prasad Devarajan ◽  
David Story ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Serum Creatinine ◽  
Sodium Bicarbonate ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

2015 ◽  
Vol 102 (5) ◽  
pp. 1059-1069 ◽  
Author(s):  
Nestan Tukvadze ◽  
Ekaterina Sanikidze ◽  
Maia Kipiani ◽  
Gautam Hebbar ◽  
Kirk A Easley ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pulmonary Tuberculosis ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
High Dose ◽  
Double Blind ◽  
Randomized Controlled ◽  
High Dose Vitamin
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