Neutrophil, Lymphocyte, and Platelet Counts and Acute Kidney Injury After Cardiovascular Surgery

2018 ◽  
Vol 32 (1) ◽  
pp. 212-222 ◽  
Author(s):  
Chang-Hoon Koo ◽  
Dhong Eun Jung ◽  
Yoon Sang Park ◽  
Jungil Bae ◽  
Youn Joung Cho ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiovascular Surgery ◽  
Kidney Injury ◽  
Platelet Counts

scholarly journals Assessment of Cardiopulmonary Bypass Duration Improves Novel Biomarker Detection for Predicting Postoperative Acute Kidney Injury after Cardiovascular Surgery

2021 ◽  
Vol 10 (13) ◽  
pp. 2741
Author(s):  
Tao Han Lee ◽  
Cheng-Chia Lee ◽  
Jia-Jin Chen ◽  
Pei-Chun Fan ◽  
Yi-Ran Tu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiopulmonary Bypass ◽  
Fatty Acid Binding Protein ◽  
Cardiovascular Surgery ◽  
Kidney Injury ◽  
Fatty Acid Binding ◽  
Discriminatory Ability ◽  
Postoperative Risk ◽  
Study Population ◽  
Postoperative Aki

Urinary liver-type fatty acid binding protein (L-FABP) is a novel biomarker with promising performance in detecting kidney injury. Previous studies reported that L-FABP showed moderate discrimination in patients that underwent cardiac surgery, and other studies revealed that longer duration of cardiopulmonary bypass (CPB) was associated with a higher risk of postoperative acute kidney injury (AKI). This study aims to examine assessing CPB duration first, then examining L-FABP can improve the discriminatory ability of L-FABP in postoperative AKI. A total of 144 patients who received cardiovascular surgery were enrolled. Urinary L-FABP levels were examined at 4 to 6 and 16 to 18 h postoperatively. In the whole study population, the AUROC of urinary L-FABP in predicting postoperative AKI within 7 days was 0.720 at 16 to 18 h postoperatively. By assessing patients according to CPB duration, the urinary L-FABP at 16 to 18 h showed more favorable discriminating ability with AUROC of 0.742. Urinary L-FABP exhibited good performance in discriminating the onset of AKI within 7 days after cardiovascular surgery. Assessing postoperative risk of AKI through CPB duration first and then using urinary L-FABP examination can provide more accurate and satisfactory performance in predicting postoperative AKI.

scholarly journals Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Renal Failure ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 1012-1019
Author(s):  
Yang Li ◽  
Zhouping Zou ◽  
Yunlu Zhang ◽  
Bowen Zhu ◽  
Yichun Ning ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiovascular Surgery ◽  
Kidney Injury

scholarly journals Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery

2016 ◽  
Vol 124 (2) ◽  
pp. 339-352 ◽  
Author(s):  
Miklos D. Kertai ◽  
Shan Zhou ◽  
Jörn A. Karhausen ◽  
Mary Cooter ◽  
Edmund Jooste ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Odds Ratio ◽  
Artery Bypass ◽  
Kidney Injury ◽  
Bypass Grafting ◽  
Cabg Surgery ◽  
Platelet Counts ◽  
Postoperative Aki

Abstract Background Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the authors explored whether postoperative nadir platelet counts are associated with acute kidney injury (AKI) and mortality after coronary artery bypass grafting (CABG) surgery. Methods The authors evaluated 4,217 adult patients who underwent CABG surgery. Postoperative nadir platelet counts were defined as the lowest in-hospital values and were used as a continuous predictor of postoperative AKI and mortality. Nadir values in the lowest 10th percentile were also used as a categorical predictor. Multivariable logistic regression and Cox proportional hazard models examined the association between postoperative platelet counts, postoperative AKI, and mortality. Results The median postoperative nadir platelet count was 121 × 109/l. The incidence of postoperative AKI was 54%, including 9.5% (215 patients) and 3.4% (76 patients) who experienced stages II and III AKI, respectively. For every 30 × 109/l decrease in platelet counts, the risk for postoperative AKI increased by 14% (adjusted odds ratio, 1.14; 95% CI, 1.09 to 1.20; P < 0.0001). Patients with platelet counts in the lowest 10th percentile were three times more likely to progress to a higher severity of postoperative AKI (adjusted proportional odds ratio, 3.04; 95% CI, 2.26 to 4.07; P < 0.0001) and had associated increased risk for mortality immediately after surgery (adjusted hazard ratio, 5.46; 95% CI, 3.79 to 7.89; P < 0.0001). Conclusion The authors found a significant association between postoperative nadir platelet counts and AKI and short-term mortality after CABG surgery.

scholarly journals SP227PREOPERATIVE URINE pH IS ASSOCIATED WITH ACUTE KIDNEY INJURY AFTER CARDIOVASCULAR SURGERY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Geun Woo Ryu ◽  
Jee Young Lee ◽  
Shinchan Kang ◽  
Sangmi Lee ◽  
Young Su Joo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiovascular Surgery ◽  
Kidney Injury ◽  
Urine Ph

scholarly journals Long-term Outcome of Patients Treated With Prophylactic Nesiritide for the Prevention of Acute Kidney Injury Following Cardiovascular Surgery

2010 ◽  
Vol 33 (4) ◽  
pp. 217-221 ◽  
Author(s):  
Vijaykumar Lingegowda ◽  
Quoc C. Van ◽  
Michiko Shimada ◽  
Thomas M. Beaver ◽  
Bhagwan Dass ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiovascular Surgery ◽  
Kidney Injury ◽  
Term Outcome ◽  
Long Term Outcome
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