Kaolin-Based Activated Coagulation Time Measured by Sonoclot in Patients Undergoing Cardiopulmonary Bypass

2007 ◽  
Vol 21 (4) ◽  
pp. 524-528 ◽  
Author(s):  
Michael T. Ganter ◽  
Antoinette Monn ◽  
Reza Tavakoli ◽  
Richard Klaghofer ◽  
Andreas Zollinger ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coagulation Time ◽  
Activated Coagulation Time

A Comparison of Activated Coagulation Time–Based Techniques for Anticoagulation During Cardiac Surgery With Cardiopulmonary Bypass

2008 ◽  
Vol 22 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Robert D. Slight ◽  
Rivan Buell ◽  
Onyekwelu C. Nzewi ◽  
David B.L. McClelland ◽  
Pankaj S. Mankad
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Coagulation Time ◽  
Activated Coagulation Time

The Effect of Lysed Platelets on Neutralization of Heparin In Vitro with Protamine as Measured by the Activated Coagulation Time (ACT)

1991 ◽  
Vol 66 (02) ◽  
pp. 213-217 ◽  
Author(s):  
Arthur P Bode ◽  
William J Castellani ◽  
Edna D Hodges ◽  
Susan Yelverton
Keyword(s):  
Platelet Rich Plasma ◽  
Coagulation Time ◽  
Platelet Factor ◽  
Platelet Suspension ◽  
Antiheparin Activity ◽  
Unit Increase ◽  
Heparin Anticoagulation ◽  
Heparin Activity ◽  
Activated Coagulation Time

SummaryThe effect of lysed platelets on the activated coagulation time (ACT) was studied in heparinized whole blood during titration with protamine. Frozen-thawed washed platelet suspension, or a chromatography fraction thereof, or autologous frozen-thawed platelet-rich plasma was added in various dilutions to freshly drawn blood anticoagulated with 3,000 USP units/1 heparin. After a 10 min incubation, the amount of protamine needed to restore the ACT to baseline ("protamine titration dose") was determined. We found that the protamine titration dose decreased in proportion to the amount of lysed platelet material added; expressed as a percentage of the total number of platelets present, each unit increase in lysed platelets produced a 1.7% ±0.8 (SD) reduction in the protamine dose needed to normalize the ACT. A heparin activity assay showed that this effect was not due to antiheparin activity of lysed platelets such as platelet factor 4 (PF4). Our data indicate that the procoagulant activity of platelet membranes reduced the sensitivity of the ACT to heparin. These findings suggest that membranous platelet microparticles may cause an inaccurate calculation, based on the ACT, of a protamine dose to reverse heparin anticoagulation in cardiopulmonary bypass procedures.

Activated Coagulation Time (ACT) and Safety of Endovascular Sheath Removal lmportance of Senpling Site.

1991 ◽  
Vol 26 (12) ◽  
pp. 1141
Author(s):  
D. S Sallee ◽  
C. J Becker ◽  
O Bouds ◽  
J Benenati ◽  
C Zemel ◽  
...  
Keyword(s):  
Coagulation Time ◽  
Activated Coagulation Time
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