Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas

2002 ◽  
Vol 33 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Jesus Lomas ◽  
M.Josefa Bello ◽  
M.Eva Alonso ◽  
Pilar Gonzalez-Gomez ◽  
Dolores Arjona ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Chromosome 22 ◽  
Nf2 Gene ◽  
Multiple Meningiomas

Multiple meningiomas in a patient with constitutional ring chromosome 22

1993 ◽  
Vol 47 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Rena Petrella ◽  
Seymour Levine ◽  
Patrick L. Wilmot ◽  
Kunjlata D. Ashar ◽  
Anthony C. Casamassima ◽  
...  
Keyword(s):  
Ring Chromosome ◽  
Chromosome 22 ◽  
Multiple Meningiomas

Multiple meningiomas in brain and lung due to acquired mutation of the NF2 gene

Neurology ◽  
2004 ◽  
Vol 62 (10) ◽  
pp. 1904-1905 ◽  
Author(s):  
O. Eckstein ◽  
A. Stemmer-Rachamimov ◽  
F. Nunes ◽  
D. Hoch ◽  
R. Ojemann ◽  
...  
Keyword(s):  
Nf2 Gene ◽  
Multiple Meningiomas

Constitutional DNA-level aberrations in chromosome 22 in a patient with multiple meningiomas

1994 ◽  
Vol 9 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Ronald H. Lekanne Deprez ◽  
Nicole A. Groen ◽  
Derrick Louz ◽  
Theo H. Van Der Kwast ◽  
Ellen C. Zwarthoff ◽  
...  
Keyword(s):  
Chromosome 22 ◽  
Multiple Meningiomas

scholarly journals Multiple Whole Chromosomal Gains Define Angiomatous Meningiomas and Are Absent From the Tumor Vasculature

2020 ◽  
Vol 79 (6) ◽  
pp. 618-625
Author(s):  
Jared T Ahrendsen ◽  
Nancy Hsu ◽  
Zena Wolf ◽  
Christine Bryke ◽  
Hemant Varma
Keyword(s):  
Gene Loss ◽  
Neutral Loss ◽  
Tumor Vasculature ◽  
Comparative Genomic ◽  
Chromosome 22 ◽  
Genetic Abnormality ◽  
Nf2 Gene ◽  
Grade Ii ◽  
Grade Iii

Abstract Angiomatous meningioma is a variant with prominent vascularity that can mimic other highly vascularized tumors and present diagnostic challenges. Unlike most meningioma variants, where NF2 gene loss on chromosome 22 is the most common genetic abnormality, angiomatous meningiomas are unique in having multiple whole chromosome gains (polysomies). We analyzed 38 meningiomas, 9 angiomatous (including 2 atypical and 1 anaplastic), and 29 nonangiomatous meningiomas, using array comparative genomic hybridization (aCGH). Angiomatous meningiomas showed multiple chromosomal alterations including polysomies and copy neutral loss of heterozygosity in comparison to nonangiomatous variants. The most frequent gains were of chromosomes 5 and 20 (100% and 89% of cases, respectively); none showed chromosome 22 loss. Furthermore, using fluorescence in situ hybridization we show that the vasculature lacked chromosomal polysomy. While generally benign, we present 2 grade II and the first cytogenetically confirmed grade III angiomatous meningioma, demonstrating their potentially aggressive behavior. Thus, multiple polysomies define angiomatous meningioma and aCGH can distinguish this variant from nonangiomatous meningiomas and other histological mimics in diagnostically challenging cases. Furthermore, the prominent vasculature is not neoplastic and likely induced by angiogenic factors. Together, these findings suggest a distinct tumorigenic pathway in angiomatous meningiomas.

Mutational analysis and expression studies of the neurofibromatosis type 2 (NF2) gene in a patient with a ring chromosome 22 and NF2

1997 ◽  
Vol 100 (1) ◽  
pp. 67-74 ◽  
Author(s):  
H. Kehrer-Sawatzki ◽  
Martin Udart ◽  
Winfrid Krone ◽  
Reinhard Baden ◽  
Raimund Fahsold ◽  
...  
Keyword(s):  
Mutational Analysis ◽  
Ring Chromosome ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Chromosome 22 ◽  
Nf2 Gene ◽  
Expression Studies
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