Lentigo maligna and superficial spreading melanoma are different in their in situ phase: An immunohistochemical study

2002 ◽  
Vol 33 (10) ◽  
pp. 1001-1005 ◽  
Author(s):  
Silviu Auslender ◽  
Aviv Barzilai ◽  
Iris Goldberg ◽  
Juri Kopolovic ◽  
Henri Trau
Keyword(s):  
Immunohistochemical Study ◽  
Lentigo Maligna ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma

Lentigo Maligna and Superficial Spreading Melanoma Differ Biologically In Their In Situ Phase.

1999 ◽  
Vol 21 (1) ◽  
pp. 72
Author(s):  
A. Barzilai ◽  
S. Auslander ◽  
I. Goldberg ◽  
J. Kopolovic ◽  
H. Trau
Keyword(s):  
Lentigo Maligna ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma

Malignant melanoma of the ear

1993 ◽  
Vol 107 (9) ◽  
pp. 798-802 ◽  
Author(s):  
Åke Davidsson ◽  
Henrik B. Hellquist ◽  
Kenneth Villman ◽  
Gunnar Westman
Keyword(s):  
Malignant Melanoma ◽  
Prognostic Value ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
External Ear ◽  
Prognostic Parameters ◽  
Lentigo Maligna ◽  
Superficial Spreading ◽  
Prognosis Estimation

AbstractThis paper reports on 16 cases of primary malignant melanoma of the external ear and the patients were followed up for two to 116 months. Fourteen patients had surgical excision with wide margins as initial treatment, whilst two had an amputation performed. Eleven patients had no recurrences, two died of other diseases, and four died of malignant melanoma. The five patients who developed recurrences received further surgery and two also radiotherapy.Seven of the cases were histologically of the nodular type, six were superficial spreading, two were in situ melanoma, and one was a lentigo maligna. The thickness ranged from 0.15 to 11.5 mm. Classification according to Clark et al. (1969) revaled that as many as nine cases were Clark level IV or more. Immunostaining with PCNA yielded strong positivity in all cases, however, statistical analysis did not reveal any differences that could be correlated to the prognosis. Estimation of the vascularization at the base of the tumours by means of immunostaining with CD31 did not reveal any significant differences either.We concluded that in our material the thickness of the tumour is of greater prognostic value than the estimation of proliferation by PCNA and vascularization by CD31. The value of PCNA and CD31 as possible prognostic parameters needs to be evaluated in a larger series. It is emphasized that malignant melanoma of the external ear is a highly malignant tumour, and that four of our 16 patients died of their disease, three of them within a year after diagnosis. Malignant melanoma of the external ear is readily inspected and thereby an early diagnosis should be possible.

Lentigo Maligna: Melanoma In Situ on Chronically Sun-Damaged Skin

2011 ◽  
Vol 135 (7) ◽  
pp. 838-841
Author(s):  
Jon A. Reed ◽  
Christopher R. Shea
Keyword(s):  
Review Of The Literature ◽  
Lentigo Maligna ◽  
Superficial Spreading ◽  
Anatomic Site ◽  
Classification Schemes ◽  
Melanoma In Situ ◽  
Personal Experiences ◽  
Lentigo Maligna Melanoma ◽  
Histologic Subtypes

Abstract Context.—Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary invasive melanomas harbor nonrandom genetic or biochemical aberrations that correlate with anatomic site or with the amount of cutaneous exposure to sunlight. It also is generally accepted that most primary invasive melanomas are preceded by an intraepidermal atypical melanocytic proliferation that lacks invasive capability (melanoma in situ). Objective.—To focus on lentigo maligna, the preinvasive/in situ form of melanoma located on chronically sun-damaged skin. Data Sources.—Review of the literature and the authors' personal experiences. Conclusions.—A better understanding of the earliest stage of melanoma progression, including the contribution of chronic exposure to ultraviolet radiation, may lead to improved classification schemes that direct more effective targeted or personalized therapies for patients.

A Case of 3-mm-Sized Superficial Spreading Melanoma in situ.

1993 ◽  
Vol 55 (1) ◽  
pp. 39-42
Author(s):  
Hironobu IHN ◽  
Shinichi SATO ◽  
Sakae HARADA ◽  
Michiro SHIMOZUMA ◽  
Hidemi NAKAGAWA
Keyword(s):  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Melanoma In Situ

Immunohistochemical Localization of Melanoma-Associated Antigen p94 kd200 with the Use of a Modified Avidin-Biotin-Complex Lectin Method

1987 ◽  
Vol 73 (5) ◽  
pp. 451-455
Author(s):  
Sylvia Garnis-Jones ◽  
David McLean ◽  
Ann Worth
Keyword(s):  
Antigen Expression ◽  
Immunohistochemical Localization ◽  
Lentigo Maligna ◽  
Blue Nevus ◽  
Superficial Spreading ◽  
Clin Pathol ◽  
Superficial Spreading Melanoma ◽  
Dysplastic Nevus ◽  
Dysplastic Nevi ◽  
Avidin Biotin Complex

The immunohistochemical localization of melanoma-associated antigen p94 kd200 was investigated in frozen sections of 3 congenital nevi, 4 benign intradermal nevi, 1 regressing nevus, 1 blue nevus, 1 dysplastic nevus, 1 lentigo maligna, 1 superficial spreading melanoma and 2 metastatic melanomas. The original avidin-biotin complex lectin method (Hsu SM, Raine L, Fanger H: Am. J. Clin. Pathol., 75: 734–738, 1981) was modified to detect the antigen. The sections were exposed to the monoclonal antibody to p94 kd200 (Hybritech Inc.), the linking biotin-labelled anti-mouse IgG, the avidin-biotin peroxidase complex and the 3-amino-9-ethylcarbazole solution in an incubator at 37 °C and 100% humidity. We found that the percentage of cells expressing p94 kd200 varied between 0 and 100% in congenital nevi, between 80 and 100% in benign intradermal nevi, between 0 and 20% in the regressing, blue and dysplastic nevi, and in the lentigo maligna, 80 to 100% in the superficial spreading melanoma, and between 0 and 40% in the metastatic melanomas. Positive cells were found to be hypomelanotic (did not have heavy melanin content). The intensity of labelling or the degree of antigen expression on benign and malignant hypomelanotic cells was also found to vary. These findings 1) reinforce the concept of quantitative rather than qualitative antigenic differences in benign and malignant cells 2) suggest that kd200 is lost with increasing pigment production 3) offer a potentially significant tool to investigate the antigenic changes during cell differentiation.

Long Term Results of Surgical Treatment of Melanoma of the Limbs

1976 ◽  
Vol 62 (2) ◽  
pp. 233-242 ◽  
Author(s):  
Natale Cascinelli ◽  
Gian Paolo Balzarini ◽  
Vincenzo Fontana ◽  
Alberto Morabito ◽  
Sergio Orefice
Keyword(s):  
Surgical Treatment ◽  
Primary Melanoma ◽  
Long Term Results ◽  
Depth Of Invasion ◽  
Node Dissection ◽  
Lentigo Maligna ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Nodular Melanoma

The outcome of surgical treatment of malignant melanoma has been evaluated on the basis of 157 limbs patients observed at the National Cancer Institute of Milan from January 1950 to December 1973. It was found that sex, site of origin and excisional biopsy do not affect the prognosis. The presence of regional nodes metastases is the factor that weight most heavily on long term results: 57.6% of patients without regional node metastases and only 15.2% of patients with positive bodes are free of disease 10 years after treatment. The depth of invasion and histological type of melanoma were found to be useful because they reveal the potential aggressiveness of the tumor: 2 out of 11 cases of lentigo maligna, 4 out of 55 cases of superficial spreading melanoma, 23 out of 91 cases of nodular melanoma and 12 out of 79 cases of Clark's level III, 8 out of 44 level IV and 8 out of 14 level V had regional nodes metastases. These two parameters were found to be correlated: lentigo maligna and superficial spreading melanoma infiltrate little as a rule whereas about half of nodular melanoma were classified as levels IV or V. Since there is not at present a definite evidence that an « elective » node dissection achieves better risults than excision only of primary melanoma followed by a possible « curative » dissection the so called « prophilactic » node dissection is considered mainly as a « staging » procedure and indicated only for level V melanoma where the incidence of nodes metastases is higher than 50%.

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