Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation: A distinct clinicopathologic entity?

2002 ◽  
Vol 33 (5) ◽  
pp. 574-575 ◽  
Author(s):  
Xavier Leroy ◽  
Sebastien Aubert ◽  
Bernard Gosselin
Keyword(s):  
Low Grade ◽  
Distal Nephron ◽  
Nephron Differentiation ◽  
Epithelial Neoplasms

Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation

2001 ◽  
Vol 32 (5) ◽  
pp. 506-512 ◽  
Author(s):  
Anil V. Parwani ◽  
Aliya N. Husain ◽  
Jonathan I. Epstein ◽  
J.Bruce Beckwith ◽  
Pedram Argani
Keyword(s):  
Low Grade ◽  
Distal Nephron ◽  
Nephron Differentiation ◽  
Epithelial Neoplasms

Is there a role for neoadjuvant chemotherapy in the management of non-carcinoid epithelial neoplasms of the appendix?

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15115-15115
Author(s):  
M. H. Katz ◽  
P. F. Mansfield ◽  
C. Eng ◽  
R. A. Wolff ◽  
P. Diaz ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Standard Of Care ◽  
Low Grade ◽  
High Grade ◽  
Appendiceal Neoplasms ◽  
Tertiary Center ◽  
Standardized Treatment ◽  
Crs And Hipec ◽  
Epithelial Neoplasms

15115 Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC) are considered the standard of care for patients with pseudomyxoma peritonei (PMP) and carcinomatosis of appendiceal origin. The role of neoadjuvant chemotherapy (CTX) in the management of these patients is unknown. Methods: Retrospective analysis of all patients evaluated for the treatment of appendiceal epithelial neoplasms at a tertiary center between 1992 and August 2006. All diagnoses were confirmed pathologically and classified by a single group of pathologists. Patients with carcinoid tumors or metastases to the appendix were excluded. Tumor histology, stage, peritoneal-based disease, and the potential for complete cytoreduction dictated treatment. Results: 250 consecutive patients were evaluated, 140 of whom had low grade disease. 114 underwent CRS and HIPEC. Median follow-up was 24 mos from referral. Average time to referral was 13 mos after diagnosis (range 0–243); 85% had undergone prior surgical therapy (median 1.3 operations, range 1–4); 22% had previous CTX consisting of many different regimens. 5- and 10-year survival for patients with low grade tumors treated with CRS and HIPEC alone (n=80) were 84% and 68%, respectively. 21 patients with low grade tumors had CTX prior to CRS and HIPEC. There was no effect on overall survival (p = 0.61). 5-and 10-year survival of 39 patients with low grade histology who did not receive CRS and HIPEC was 55% and 30%, respectively (p = 0.009). 83 patients with intermediate and high-grade disease who received CTX but not CRS and HIPEC had a 5- year survival of 27%. 5-year survival for patients with intermediate or high grade disease who underwent CRS and HIPEC (n=13) was 67%. Conclusions: Patients with peritoneal-based disease from non-carcinoid epithelial neoplasms of the appendix who undergo CRS and HIPEC have a more favorable survival. Currently there is no survival advantage to the use of CTX before CRS and HIPEC for low grade appendiceal neoplasms. The role of neoadjuvant CTX and biologic agents for patients with high grade neoplasms needs to be determined. Early referral to a peritoneal malignancy center will help standardized treatment for these patients. No significant financial relationships to disclose.

scholarly journals Association Between Charlson Comorbidity Index and Complications of Endoscopic Resection of Gastric Neoplasms in Elderly Patients

2019 ◽  
Author(s):  
Sunmin Kim ◽  
Dong Hyun Kim ◽  
Seon-Young Park ◽  
Chang Hwan Park ◽  
Hyun Soo Kim ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Endoscopic Resection ◽  
Charlson Comorbidity Index ◽  
Gastric Neoplasms ◽  
Low Grade ◽  
Efficacy And Safety ◽  
Respiratory Complications ◽  
Comorbidity Index ◽  
Epithelial Neoplasms ◽  
Procedural Outcomes

Abstract Background Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, the relationship between comorbidities and complications of endoscopic resection is not well established. Therefore, we aimed to evaluate the efficacy and safety of endoscopic resection of gastric epithelial neoplasms in extremely elderly patients. Methods From October 2008 to December 2017, 4475 consecutive patients underwent endoscopic resection of gastric epithelial neoplasms. Among them, 242 were 75 years or older. We assessed Charlson comorbidity index (CCI) scores, procedural outcomes, and procedure- and sedation-related complications related to endoscopic resection. Results Mean patient age was 78 (range, 75–88) years. Of the 242 patients, 124 (51.2%) had low-grade dysplasia and 112 (46.3%) had high-grade dysplasia or adenocarcinoma. The most common comorbidity was hypertension (55.4%), followed by diabetes (23.1%). The mean CCI score was 5.0 ± 1.5. Eighty patients (33.1%) had a CCI score ≥ 6. During the procedure, 10 (4.1%) patients had desaturation that recovered by flumazenil use with mask (n=2) or Ambu bag (n=3) ventilation. During subsequent admission, in addition to abdominal pain (35.1%), atelectasis and pneumonia occurred in 45 (18.6%) patients, hypotension in 27 (11.2%), and post-procedural bleeding in 12 (5.0%). Respiratory complications were more common in patients with a CCI score ≥ 6 (23/80, 28.7%) than in those with a CCI score < 6 (22/162, 13.6%, P=0.001). Conclusions CCI score is related to respiratory complications of endoscopic resection in elderly patients. Endoscopic resection must be performed cautiously, particularly in elderly patients with a high CCI score, to prevent respiratory complications.

Low-grade renal epithelial tumor originating from the distal nephron

2004 ◽  
Vol 11 (2) ◽  
pp. 68-73 ◽  
Author(s):  
NOBORU HARA ◽  
MAKOTO KAWAGUCHI ◽  
HIROSHI KOIKE ◽  
TOSHIKI TSUTSUI ◽  
RYUJI TAKAGI ◽  
...  
Keyword(s):  
Low Grade ◽  
Distal Nephron ◽  
Epithelial Tumor

scholarly journals Papillary Renal Adenoma of Distal Nephron Differentiation in a Horse

2007 ◽  
Vol 69 (7) ◽  
pp. 763-765 ◽  
Author(s):  
Kazuya MATSUDA ◽  
Yousuke KOUSAKA ◽  
Natsuko NAGAMINE ◽  
Nobuo TSUNODA ◽  
Hiroyuki TANIYAMA
Keyword(s):  
Distal Nephron ◽  
Nephron Differentiation

Long-Term Outcomes of Patients With Low Grade Cystic Renal Epithelial Neoplasms

Urology ◽  
2019 ◽  
Vol 133 ◽  
pp. 145-150 ◽  
Author(s):  
Mary E. Westerman ◽  
John C. Cheville ◽  
Christine M. Lohse ◽  
Vidit Sharma ◽  
Stephen A. Boorjian ◽  
...  
Keyword(s):  
Low Grade ◽  
Long Term Outcomes ◽  
Epithelial Neoplasms

scholarly journals Association Between Charlson Comorbidity Index and Complications of Endoscopic Resection of Gastric Neoplasms in Elderly Patients

2020 ◽  
Author(s):  
Sunmin Kim ◽  
Dong Hyun Kim ◽  
Seon-Young Park ◽  
Chang Hwan Park ◽  
Hyun Soo Kim ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Endoscopic Resection ◽  
Charlson Comorbidity Index ◽  
Gastric Neoplasms ◽  
Low Grade ◽  
Efficacy And Safety ◽  
Respiratory Complications ◽  
Comorbidity Index ◽  
Epithelial Neoplasms ◽  
Procedural Outcomes

Abstract Background: Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, the relationship between comorbidities and complications of endoscopic resection is not well established. Therefore, we aimed to evaluate the efficacy and safety of endoscopic resection of gastric epithelial neoplasms in extremely elderly patients. Methods: From October 2008 to December 2017, 4475 consecutive patients underwent endoscopic resection of gastric epithelial neoplasms. Among them, 242 were 75 years or older. We assessed Charlson comorbidity index (CCI) scores, procedural outcomes, and procedure- and sedation-related complications related to endoscopic resection. Results: Mean patient age was 78.7 ± 3.2 years. Of the 242 patients, 124 (51.2%) had low-grade dysplasia and 112 (46.3%) had adenocarcinoma. The most common comorbidity was hypertension (55.4%), followed by diabetes (23.1%). The mean CCI score was 1.67 ± 1.43. Sixty patients (24.8%) had a CCI score ≥ 3. During the procedure, 10 (4.1%) patients had desaturation that recovered by flumazenil use with mask (n=2) or Ambu bag (n=3) ventilation. During subsequent admission, atelectasis or pneumonia occurred in 45 (18.6%) patients, post-procedural bleeding in 12 (5.0%), and perforation in 3 (1.2%). Respiratory complications were more common in patients with a CCI score ≥ 3 (20/60, 33.3%) than in those with a CCI score < 3 (25/182, 13.7%, P=0.002). Conclusions: CCI score is related to respiratory complications of endoscopic resection in extremely elderly patients. Endoscopic resection must be performed cautiously, particularly in elderly patients with a high CCI score, to prevent respiratory complications.

Sign in / Sign up

Export Citation Format

Share Document