Rectal distention testing in patients with irritable bowel syndrome: Sensitivity, specificity, and predictive values of pain sensory thresholds

2002 ◽  
Vol 122 (7) ◽  
pp. 1771-1777 ◽  
Author(s):  
Mickael Bouin ◽  
Victor Plourde ◽  
Michel Boivin ◽  
Monique Riberdy ◽  
France Lupien ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sensory Thresholds ◽  
Predictive Values ◽  
Irritable Bowel ◽  
Sensitivity Specificity ◽  
Rectal Distention

Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome

2001 ◽  
Vol 95 (1-6) ◽  
pp. 153-156 ◽  
Author(s):  
József Czimmer ◽  
Gábor Sütő ◽  
Agnes Király ◽  
Gyula Mózsik
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sensory Thresholds ◽  
Irritable Bowel

Alterations in cerebral potentials evoked by rectal distention and drinking ice water in patients with irritable bowel syndrome

2006 ◽  
Vol 21 (12) ◽  
pp. 1844-1849 ◽  
Author(s):  
Xiu Li Zuo ◽  
Yan Qing Li ◽  
Kun Ming Huang ◽  
Rong Guang Kuang ◽  
Guo Ping Lv ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Irritable Bowel ◽  
Ice Water ◽  
Rectal Distention

Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention

2000 ◽  
Vol 118 (5) ◽  
pp. 842-848 ◽  
Author(s):  
Howard Mertz ◽  
Victoria Morgan ◽  
Gordon Tanner ◽  
David Pickens ◽  
Ronald Price ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cerebral Activation ◽  
Control Subjects ◽  
Irritable Bowel ◽  
And Control ◽  
Rectal Distention

Reproducibiility of sensations induced by rectal distention in patients with irritable bowel syndrome: Role of rectal contractions

2000 ◽  
Vol 118 (4) ◽  
pp. A842 ◽  
Author(s):  
Maura Corsetti ◽  
Sherrie Bhoori ◽  
Paolo A. Bianchi ◽  
Guido Basilisco
Keyword(s):  
Irritable Bowel Syndrome ◽  
Irritable Bowel ◽  
Rectal Distention

scholarly journals Confocal laser endomicroscopy detects colonic inflammation in patients with irritable bowel syndrome: a prospective study

2020 ◽  
Vol 08 (04) ◽  
pp. E550-E557 ◽  
Author(s):  
Carlos Robles-Medranda ◽  
Roberto Oleas ◽  
Manuel Valero ◽  
Miguel Puga-Tejada ◽  
Miguel Soria-Alcívar ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Histological Evaluation ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Control Group ◽  
Tertiary Institution ◽  
Predictive Values ◽  
Colorectal Mucosa ◽  
Irritable Bowel ◽  
Inflammatory Changes

Abstract Background and aims Irritable bowel syndrome (IBS) is considered to be a functional disease, but recent data indicate measurable organic alterations. We aimed to determine the presence of colorectal mucosa microinflammation in vivo via probe-confocal laser endomicroscopy (pCLE) and histological evaluation in IBS patients. Methods This was a prospective, controlled, nonrandomized single-blind diagnostic trial performed in a tertiary institution. pCLE images and targeted biopsy of each colon segment obtained during colonoscopies of IBS patients and controls were analyzed for inflammatory changes. Biopsies were classified using the Geboes scale, and the odds ratio and overall diagnostic accuracy were calculated. Results During the 15-month study period, 37 patients were allocated to each group. The mean age was 53.1 ± 14.3 years; 64.9 % were female. Signs of colonic mucosa inflammation were evident on 65.8 % of pCLE images from IBS patients compared to 23.4 % of images from controls (OR 6.28; 4.14–9.52; P < 0.001). In total, 20/37 patients had microinflammation via pCLE in ≥ 3 colon segments in the IBS group, compared to 1/37 in the control group. A Geboes score > 0 was attributed to 60.8 % of biopsies from patients in the IBS group compared to 27.5 % of biopsies from the control group. The sensitivity, specificity, positive and negative predictive values, observed and interrater agreement of pCLE-detected inflammatory changes in IBS using histology as gold standard were 76 %, 91 %, 76 %, 91 %, 86.5 %, and 66.8 %, respectively. Conclusions Patients with IBS have a six-fold higher prevalence of colorectal mucosa microinflammation than healthy controls. pCLE might be a reliable method to detect colorectal mucosa microinflammation in IBS patients.

Motor and sensory function of the rectum in different types of irritable bowel syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A399-A399
Author(s):  
J STEENS ◽  
P SCHAAR ◽  
C LAMERS ◽  
A MASCLEE
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sensory Function ◽  
Different Types ◽  
Irritable Bowel

Rome I versus Rome II; Overlap in patients enrolled in tegaserod phase III clinical trials for irritable bowel syndrome (IBS)

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
B NAULT ◽  
S SUE ◽  
J HEGGLAND ◽  
S GOHARI ◽  
G LIGOZIO ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Irritable Bowel Syndrome ◽  
Phase Iii ◽  
Phase Iii Clinical Trials ◽  
Irritable Bowel ◽  
Rome I
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