Somatic mutation of the β2-microglobulin gene associates with unfavorable prognosis in gastrointestinal cancer of the microsatellite mutator phenotype

2001 ◽  
Vol 120 (6) ◽  
pp. 1565-1567 ◽  
Author(s):  
Hiroyuki Yamamoto ◽  
Kentaro Yamashita ◽  
Manuel Perucho
Keyword(s):  
Somatic Mutation ◽  
Gastrointestinal Cancer ◽  
Mutator Phenotype ◽  
Β2 Microglobulin

Gastrointestinal cancer of the microsatellite mutator phenotype pathway

2002 ◽  
Vol 37 (3) ◽  
pp. 153-163 ◽  
Author(s):  
Hiroyuki Yamamoto ◽  
Kohzoh Imai ◽  
Manuel Perucho
Keyword(s):  
Gastrointestinal Cancer ◽  
Mutator Phenotype

Is serum β2-microglobulin a tumor marker in gastrointestinal cancer?

1980 ◽  
Vol 106 (3) ◽  
pp. 309-317 ◽  
Author(s):  
Hans-Jurgen Staab ◽  
F.Alfred Anderer ◽  
Klaus Hiesche ◽  
Elisabeth Wehrle ◽  
Wolfram Rodatz
Keyword(s):  
Tumor Marker ◽  
Gastrointestinal Cancer ◽  
Β2 Microglobulin

Expression of splice variants; The human cholecystokinin-B receptor in association with gastrointestinal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A507-A507
Author(s):  
D KANG ◽  
Y WHANG ◽  
J YOO ◽  
I SONG ◽  
J OH ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Splice Variants

CD9 negatively regulates growth signaling of the gastrointestinal cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A660-A660
Author(s):  
Y MURAYAMA ◽  
Y SHINOMURA ◽  
J MIYAGAWA ◽  
H YOSHIDA ◽  
T KIYOHARA ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Gastrointestinal Cancer

The Gastrointestinal Cancer Committee of the National Advisory Cancer Council

1955 ◽  
Vol 29 (4) ◽  
pp. 492-493
Author(s):  
George T. Pack ◽  
Morris K. Barrett
Keyword(s):  
Gastrointestinal Cancer ◽  
Cancer Council

A NMR study of human β2 microglobulin

1981 ◽  
Vol 78 ◽  
pp. 837-841 ◽  
Author(s):  
Marcel Sarrazin ◽  
Claudette Briand ◽  
Madeleine Bourdeaux ◽  
Michèle Chauvet ◽  
Claude Vincent ◽  
...  
Keyword(s):  
Β2 Microglobulin ◽  
Nmr Study

Urinary Beta-Thromboglobulin Correlates with Impairment of Renal Function in Patients with Diabetic Nephropathy

1986 ◽  
Vol 56 (02) ◽  
pp. 229-231 ◽  
Author(s):  
A H Hopper ◽  
H Tindall ◽  
J A Davies
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Microvascular Disease ◽  
Normal Subjects ◽  
Specific Protein ◽  
Creatinine Concentration ◽  
Β2 Microglobulin ◽  
Plasma Creatinine Concentration ◽  
Insulin Dependent ◽  
Indium 111

SummaryTBeta-thromboglobulin (βTG) is a platelet-specific protein and since its concentration in plasma rises when platelets are activated, it has been used as an indicator of platelet involvement in vascular disease. Since platelets might be involved in the pathogenesis of diabetic microvascular disease we measured urinary βTG in 20 insulin-dependent diabetics with nephropathy and compared the results with those from 20 normal subjects. Measurement of βTG in urine was undertaken to avoid errors induced by blood sampling and to gain information over a prolonged period using a single assay. Measurements were made of βTG, β2-microglobulin and total protein in urine collected for 24 h and creatinine and β2 microglobulin in plasma. Survival of indium-111-labelled platelets was measured in nine patients. Urinary PTG was significantly (p <0.02) increased in the 20 patients compared with 20 normal volunteers (median value 1.3 vs 0.8 μg/24 h). There was a strong correlation between urinary βTG excretion and plasma creatinine concentration (r = 0.8, p <0.0001) and plasma β2-microglobulin concentration (r = 0.9, p <0.0001). Urinary βTG concentration did not correlate with platelet survival. The results indicate that although urinary βTG is significantly increased in patients with diabetic nephropathy its concentration in urine correlates with indicators of glomerular filtration rather than with a test of platelet activation.

Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer

2020 ◽  
Author(s):  
S Leyvraz ◽  
J Berlin ◽  
DS Hong ◽  
J Deeken ◽  
V Boni ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Efficacy And Safety

Major Hereditary Gastrointestinal Cancer Syndromes: a Narrative Review

2017 ◽  
Vol 26 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Lakshmi Manogna Chintalacheruvu ◽  
Trudy Shaw ◽  
Avanija Buddam ◽  
Osama Diab ◽  
Thamer Kassim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Testing ◽  
Gastrointestinal Cancer ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Clinical Manifestations ◽  
Micro Rna ◽  
Diffuse Gastric Cancer ◽  
Adenomatous Polyposis ◽  
Cancer Syndromes

Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes.Key words:  −  −  −  − .Abbreviations: ACG: American College of Gastroenterology; AFAP: attenuated FAP; APC: adenomatous polyposis coli; CDH1: E-cadherin; CHRPE: congenital hypertrophy of the retinal pigment epithelium; CRC: colorectal cancer; FAMMM: Familial atypical multiple mole melanoma; FAP: Familial adenomatous polyposis; GC: gastric cancer; HDGC: Hereditary diffuse gastric cancer; IHC: immunohistochemical; IPAA: ileal pouch–anal anastomosis; IRA: ileorectal anastomosis; MSI: microsatellite instability; MMR: mismatch repair; miRNA: micro RNA.

Sign in / Sign up

Export Citation Format

Share Document