Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk

2000 ◽  
Vol 119 (6) ◽  
pp. 1740-1744 ◽  
Author(s):  
E.Jan Irvine ◽  
John K. Marshall
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability ◽  
Familial Risk

scholarly journals Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease

2020 ◽  
Vol 159 (6) ◽  
pp. 2092-2100.e5 ◽  
Author(s):  
Williams Turpin ◽  
Sun-Ho Lee ◽  
Juan Antonio Raygoza Garay ◽  
Karen L. Madsen ◽  
Jonathan B. Meddings ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability

Intestinal permeability in Crohn's disease patients and their first degree relatives

2001 ◽  
Vol 33 (8) ◽  
pp. 680-685 ◽  
Author(s):  
M. Secondulfo ◽  
L. de Magistris ◽  
R. Fiandra ◽  
L. Caserta ◽  
M. Belletta ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability ◽  
First Degree Relatives

scholarly journals Assessing intestinal permeability in Crohn’s disease patients using orally administered 52Cr-EDTA

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211973 ◽  
Author(s):  
Julius Z. H. von Martels ◽  
Arno R. Bourgonje ◽  
Hermie J. M. Harmsen ◽  
Klaas Nico Faber ◽  
Gerard Dijkstra
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability

scholarly journals Intestinal permeability in patients with Crohn's disease.

Gut ◽  
1994 ◽  
Vol 35 (11) ◽  
pp. 1675-1676 ◽  
Author(s):  
J B Meddings ◽  
L R Sutherland ◽  
G R May
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability

Is an increased intestinal permeability a valid predictor of relapse in Crohn's disease?

2000 ◽  
Vol 118 (4) ◽  
pp. A104
Author(s):  
Jimmy Jorgensen ◽  
Poul J. Ranlov ◽  
Poul J. Bjerrum ◽  
Henrik Diemer ◽  
Kirsten Bisgaard ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Permeability ◽  
Valid Predictor

scholarly journals Intestinal Permeability before and after Ibuprofen in Families of Children with Crohn’s Disease

1999 ◽  
Vol 13 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Samuel A Zamora ◽  
Robert J Hilsden ◽  
Jon B Meddings ◽  
J Decker Butzner ◽  
R Brent Scott ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Acetylsalicylic Acid ◽  
Intestinal Permeability ◽  
Control Group ◽  
Reference Limit ◽  
First Degree Relatives ◽  
Before And After ◽  
Healthy Control ◽  
Upper Reference Limit

BACKGROUND: Members of a subset of first-degree relatives of adults with Crohn’s disease have been shown to have an increased baseline intestinal permeability and/or an exaggerated increase in intestinal permeability after the administration of acetylsalicylic acid.PURPOSE: To determine intestinal permeability in unaffected first-degree relatives of children with Crohn’s disease before and after the administration of an ibuprofen challenge.METHODS: Lactulose-mannitol ratios, a measure of intestinal permeability, were determined in 14 healthy control families (41 subjects) and 14 families with a child with Crohn’s disease (36 relatives, 14 probands) before and after ingestion of ibuprofen. An upper reference limit was defined using the control group as mean ± 2 SD.RESULTS: The proportion of healthy, first-degree relatives with an exaggerated response to ibuprofen (20%, 95% CI 7% to 33%) was significantly higher than controls (P=0.003). The exaggerated response was more common among siblings than among parents of pediatric probands.CONCLUSIONS: Members of a subset of first-degree relatives of children with Crohn’s disease have an exaggerated increase in intestinal permeability after ibuprofen ingestion. These findings are compatible with there being a genetic link between abnormalities of intestinal permeability and Crohn’s disease.

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