scholarly journals Scatterplots of RR and RT interval variability bring evidence for diverse non-linear dynamics of heart rate and ventricular repolarization duration in coronary heart disease

EP Europace ◽  
2001 ◽  
Vol 3 (1) ◽  
pp. 39-45 ◽  
Author(s):  
M Sosnowski
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ventricular Repolarization ◽  
Linear Dynamics ◽  
Non Linear

Non-linear analysis of heart rate variability in patients with coronary heart disease

2003 ◽  
Author(s):  
G. Krstacic ◽  
A. Krstacic ◽  
M. Martinis ◽  
E. Vargovic ◽  
A. Knezevic ◽  
...  
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Linear Analysis ◽  
Non Linear

Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report

Brain Injury ◽  
2008 ◽  
Vol 22 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Marco Sarà ◽  
Fabio Sebastiano ◽  
Simona Sacco ◽  
Francesca Pistoia ◽  
Paolo Onorati ◽  
...  
Keyword(s):  
Heart Rate ◽  
Preliminary Report ◽  
Vegetative State ◽  
Persistent Vegetative State ◽  
Linear Dynamics ◽  
Non Linear

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

2014 ◽  
Vol 44 (14) ◽  
pp. 2975-2984 ◽  
Author(s):  
F. Zimmermann-Viehoff ◽  
L. K. Kuehl ◽  
H. Danker-Hopfe ◽  
M. A. Whooley ◽  
C. Otte
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Tricyclic Antidepressants ◽  
Autonomic Function ◽  
Control Group ◽  
Observational Period ◽  
Lower Heart Rate

BackgroundAntidepressants reduce depressive symptoms in patients with coronary heart disease, but they may be associated with increased mortality. This study aimed to examine whether the use of tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRI) is associated with mortality in patients with coronary heart disease, and to determine whether this association is mediated by autonomic function.MethodA total of 956 patients with coronary heart disease were followed for a mean duration of 7.2 years. Autonomic function was assessed as heart rate variability, and plasma and 24-h urinary norepinephrine.ResultsOf 956 patients, 44 (4.6%) used TCA, 89 (9.3%) used SSRI, and 823 (86.1%) did not use antidepressants. At baseline, TCA users exhibited lower heart rate variability and higher norepinephrine levels compared with SSRI users and antidepressant non-users. At the end of the observational period, 52.3% of the TCA users had died compared with 38.2% in the SSRI group and 37.3% in the control group. The adjusted hazard ratio (HR) for TCA use compared with non-use was 1.74 [95% confidence interval (CI) 1.12–2.69, p = 0.01]. Further adjustment for measures of autonomic function reduced the association between TCA use and mortality (HR = 1.27, 95% CI 0.67–2.43, p = 0.47). SSRI use was not associated with mortality (HR = 1.15, 95% CI 0.81–1.64, p = 0.44).ConclusionsThe use of TCA was associated with increased mortality. This association was at least partially mediated by differences in autonomic function. Our findings suggest that TCA should be avoided in patients with coronary heart disease.

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