scholarly journals Dipyridamole in chronic stable angina pectoris. A randomized, double blind, placebo-controlled, parallel group study

2001 ◽  
Vol 22 (19) ◽  
pp. 1785-1793 ◽  
Author(s):  
E Picano, on behalf of the PISA (Pers
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Parallel Group Study ◽  
Parallel Group

scholarly journals A double blind placebo controlled comparison of verapamil, atenolol, and their combination in patients with chronic stable angina pectoris.

Heart ◽  
1987 ◽  
Vol 57 (4) ◽  
pp. 336-343 ◽  
Author(s):  
I N Findlay ◽  
K MacLeod ◽  
G Gillen ◽  
A T Elliott ◽  
T Aitchison ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Double Blind Placebo

Randomized Double-blind Placebo-controlled Comparison of Nicardipine and Nifedipine in Patients with Chronic Stable Angina Pectoris

CHEST Journal ◽  
1986 ◽  
Vol 89 (2) ◽  
pp. 260-265 ◽  
Author(s):  
Michael J. Bowles ◽  
Nardev S. Khurmi ◽  
Martin J. O’Hara ◽  
Edward B. Rafiery
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Double Blind Placebo

Chronic Stable Angina: Comparison of Verapamil and Propranolol

1982 ◽  
Vol 10 (5) ◽  
pp. 361-366 ◽  
Author(s):  
E Southall ◽  
N R Nutt ◽  
R D Thomas
Keyword(s):  
Angina Pectoris ◽  
Exercise Testing ◽  
Stable Angina ◽  
Crossover Trial ◽  
Chronic Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Exercise Time ◽  
Electrocardiographic Monitoring ◽  
St Segment

The effect of verapamil 120 mg t.d.s. was compared with propranolol 160 mg b.d. in the treatment of stable angina pectoris. Nineteen patients were studied in a randomized, double-blind, crossover trial, using patient diaries, exercise-testing and ambulatory electrocardiographic monitoring. Both drugs were given for 1 month. On average the number of attacks of angina was reduced equally by verapamil and propranolol. The degree of electrocardiographic evidence of myocardial ischaemia was decreased by the same amount, but verapamil was significantly more effective in prolonging the exercise time. Both drugs reduced the number of episodes of ST-segment depression during 24 hours of ambulatory electrocardiographic monitoring, which was analyzed in nine patients. It is concluded that verapamil compares very favourably with propranolol in the treatment of stable angina, and is more beneficial in improving exercise capacity.

scholarly journals Acupoint Application in Patients with Chronic Stable Angina Pectoris: Study Protocol of a Randomized, Double-Blind, Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yulan Ren ◽  
Dehua Li ◽  
Hui Zheng ◽  
Junling Lv ◽  
Junyan Leng ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Study Protocol ◽  
Stable Angina ◽  
Controlled Trial ◽  
Chronic Stable Angina ◽  
Treatment Phase ◽  
Controlled Clinical Trial ◽  
Stable Angina Pectoris ◽  
Double Blind

Background. Chronic stable angina pectoris (CSAP) is a major syndrome of ischemic heart disease (IHD). CSAP manifests as chest pain or discomfort and affects patients’ quality of life. Acupoint application (AP) has been reported to be effective for managing the symptoms of CSAP, but the evidence is not convincing. Therefore, we designed a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy of AP in the treatment of CSAP.Methods and Analysis. Two hundred participants with CSAP will be randomly assigned in a 1 : 1 : 1 : 1 ratio into 4 groups. All participants will receive 12 sessions of treatment in 4 weeks and the same basic treatment procedure. The participants will be visited and assessed for 12 weeks, including a 4-week screening, a 4-week treatment phase, and a 4-week follow-up phase. The primary outcome is the change in the total frequency of self-reported angina attack at 4th week compared with the baseline. The secondary outcomes include the intensity of angina pain, consumption of nitroglycerin orSuxiao Jiuxinpills, CCS angina classification, SAQ, SAS and SDS score.Ethics. The study protocol has been reviewed and approved by the Sichuan Regional Ethics Review Committee on TCM (number 2013kl-001). This trial is registered with clinicaltrials.govNCT02029118.

An Acute Double-Blind Placebo-Controlled Study of Transdermal Glyceryl Trinitrate with 12 Months' Follow-up in Patients with Stable Angina Pectoris

1987 ◽  
Vol 15 (4) ◽  
pp. 198-204
Author(s):  
W. Heepe
Keyword(s):  
Angina Pectoris ◽  
Glyceryl Trinitrate ◽  
Stable Angina ◽  
Controlled Study ◽  
Transdermal Patch ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Acute Study

In an acute double-blind placebo-controlled randomized crossover study, 1 day of treatment with a glyceryl trinitrate transdermal patch releasing 10 mg glyceryl trinitrate daily was compared with placebo in 40 men with stable angina pectoris. Subsequently, the patients participated in an uncontrolled efficacy and tolerability study during which the transdermal patch was applied to the front of the chest for 22–23 hours daily for 12 months. In the acute study, one patch of glyceryl trinitrate or matching placebo was applied at 8.00 a.m. for 24 h; 48 h later the other treatment was applied. Bicycle ergometry was performed 24 and 16 h before the beginning of the treatment, and 8 and 24 h after each dose. Ergometry was repeated after 1, 3, 6 and 12 months' treatment with one patch daily of glyceryl trinitrate during the long-term open follow-up study. In the acute study, a significant reduction of ST-segment depression was observed with treatment compared with placebo. This reduction persisted throughout the 12 months of the open study. During this period also, the mean number of anginal attacks was reduced from 5.3 to 3.6 during week 1 of treatment, and this reduction was maintained throughout the 12 months of the study. No patient needed to be withdrawn because of systemic side-effects or local intolerance to the patch.

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