Regional toxicity after isolated limb perfusion with melphalan and tumour necrosis factor- α versus toxicity after melphalan alone

2001 ◽  
Vol 27 (4) ◽  
pp. 390-395 ◽  
Author(s):  
B.C. Vrouenraets ◽  
A.M.M. Eggermont ◽  
A.A.M. Hart ◽  
J.M. Klaase ◽  
A.N. van Geel ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Isolated Limb Perfusion ◽  
Tumour Necrosis Factor Α ◽  
Limb Perfusion ◽  
Factor Α ◽  
Necrosis Factor

Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis

2014 ◽  
Vol 101 (13) ◽  
pp. 1674-1680 ◽  
Author(s):  
D. L. M. van Broekhoven ◽  
J. P. Deroose ◽  
S. Bonvalot ◽  
A. Gronchi ◽  
D. J. Grünhagen ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Aggressive Fibromatosis ◽  
Isolated Limb Perfusion ◽  
Tumour Necrosis Factor Α ◽  
Limb Perfusion ◽  
Factor Α ◽  
Necrosis Factor

Low-dose tumour necrosis factor α and melphalan in hyperthermic isolated limb perfusion

1993 ◽  
Vol 80 (8) ◽  
pp. 995-997 ◽  
Author(s):  
S. Hill ◽  
W. J. Fawcett ◽  
J. Sheldon ◽  
N. Soni ◽  
T. Williams ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Low Dose ◽  
Isolated Limb Perfusion ◽  
Tumour Necrosis Factor Α ◽  
Limb Perfusion ◽  
Factor Α ◽  
Necrosis Factor

Long-term outcome of isolated limb perfusion with tumour necrosis factor-α for patients with melanoma in-transit metastases

2011 ◽  
Vol 98 (11) ◽  
pp. 1573-1580 ◽  
Author(s):  
J. P. Deroose ◽  
D. J. Grünhagen ◽  
A. N. van Geel ◽  
J. H. W. de Wilt ◽  
A. M. M. Eggermont ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Limb Perfusion ◽  
Factor Α ◽  
In Transit ◽  
Necrosis Factor

Substrate specificity and inducibility of TACE (tumour necrosis factor α-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity

2003 ◽  
Vol 70 ◽  
pp. 39-52 ◽  
Author(s):  
Roy A. Black ◽  
John R. Doedens ◽  
Rajeev Mahimkar ◽  
Richard Johnson ◽  
Lin Guo ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Recent Work ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Transforming Growth Factor ◽  
Intrinsic Activity ◽  
Converting Enzyme ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Tumour necrosis factor α (TNFα)-converting enzyme (TACE/ADAM-17, where ADAM stands for a disintegrin and metalloproteinase) releases from the cell surface the extracellular domains of TNF and several other proteins. Previous studies have found that, while purified TACE preferentially cleaves peptides representing the processing sites in TNF and transforming growth factor α, the cellular enzyme nonetheless also sheds proteins with divergent cleavage sites very efficiently. More recent work, identifying the cleavage site in the p75 TNF receptor, quantifying the susceptibility of additional peptides to cleavage by TACE and identifying additional protein substrates, underlines the complexity of TACE-substrate interactions. In addition to substrate specificity, the mechanism underlying the increased rate of shedding caused by agents that activate cells remains poorly understood. Recent work in this area, utilizing a peptide substrate as a probe for cellular TACE activity, indicates that the intrinsic activity of the enzyme is somehow increased.

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