Surgical treatment of malignant tumours of the sacrum

1999 ◽  
Vol 25 (1) ◽  
pp. 44-49 ◽  
Author(s):  
M.H. Ozdemir ◽  
I. Gürkan ◽  
Y. Yildiz ◽  
C. Yilmaz ◽  
Y. Saglik
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumours

Benign tumours: The forgotten neoplasms

2019 ◽  
pp. 453-462
Author(s):  
Francesco Pezzella ◽  
Adrian L. Harris ◽  
Mahvash Tavassoli
Keyword(s):  
Surgical Treatment ◽  
Malignant Lesion ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Malignant Tumours ◽  
Neoplastic Growth ◽  
Risk Of Progression ◽  
Benign Nature ◽  
Malignant Lesions ◽  
Benign Tumours

Benign tumours are exceedingly common neoplastic growth which, similar to malignant tumours, recognize genetic basis. However, benign tumours differ in one essential characteristic: by definition, these neoplasms do not produce metastases. Only some types are at risk of progression into a malignant lesion. Complete surgical removal is always curative. Because of their non-aggressive ‘benign’ nature and, in many cases, easy, straightforward possibility of surgical treatment, the biology of these tumours has not received much attention as compared to that of the malignant neoplasms. However, several studies have recently started to unveil the involvement of mechanisms overlapping with those of the malignant lesions, raising the issue that, by ignoring the biology of benign tumours, we are perhaps missing information vital for understanding malignancies. Only a few types have been subjects of studies comparable to that we can found in malignancy and therefore their biology is still largely unknown.

scholarly journals A massive malignant phyllodes tumor – case study

2021 ◽  
Vol 34 (1) ◽  
pp. 17-19
Author(s):  
Barbara Madej-Czerwonka
Keyword(s):  
Surgical Treatment ◽  
Adjuvant Therapy ◽  
Breast Neoplasm ◽  
Phyllodes Tumor ◽  
Late Diagnosis ◽  
Malignant Tumours ◽  
Treatment Methods ◽  
Malignant Phyllodes Tumor ◽  
Breast Malignancy

Abstract The paper aims to introduce the case of an extensive breast malignancy – phyllodes tumor. This type of breast neoplasm is relatively rare. Indeed, it accounts for only 0.3-1% of all breast malignant tumours. In the paper, patient, disease, and treatment methods were described and evaluated. The efficacy of surgical treatment and adjuvant therapy (radiotherapy and chemotherapy) was assessed based on literature data. The authors concluded that late diagnosis of phyllodes tumor causes the necessity of mastectomy and radiotherapy and aggravates the prognosis.

Phyllodes tumours – a retrospective review of 83 clinical cases

2019 ◽  
Vol 98 (9) ◽  
pp. 362-369
Keyword(s):  
Surgical Treatment ◽  
Retrospective Review ◽  
Total Mastectomy ◽  
Malignant Tumours ◽  
Biological Behaviour ◽  
Free Margin ◽  
Borderline Tumour ◽  
Local Progression ◽  
Benign Tumours ◽  
Phyllodes Tumours

Introduction: Phyllodes tumours are rare, accounting for 0.3–1.0% of all primary breast tumours. According to biological behaviour, they are divided into three categories: benign, borderline and malignant. Due to the rare incidence, the requirements for the radicality of surgical treatment are not well known. According to respected foreign recommendations, resection with a free margin of 10 mm or more is desirable. Methods: A retrospective review of patients, who underwent surgical treatment due to phyllodes tumour in the Masaryk Memorial Cancer lnstitute in 2003–2014. Results: 83 patients were evaluated with a median follow-up of 68.0 months. Benign tumours accounted for 62.3%, borderline tumours accounted for 16.9% and malignant accounted for 20.8% of all tumours. Malignant phyllodes tumours reached a bigger average size (84.9 mm) than borderline (41.4 mm) and benign tumours (33.3 mm) and occurred in older patients (mean 56.4 years) than benign (mean 42.5 years). Results from preoperative core-cut biopsy were often inaccurate. In 70 cases, the primary resection was breast preserving, but the free margin above 1 mm was achieved only in 13 cases. The width of the resection edge never exceeded the recommended 10 mm. Nevertheless, there was a relapse in benign tumours in two cases and in the borderline tumours only in one case. Malignant tumours recurred more frequently, even after total mastectomy. Four patients with malignant tumours experienced distant metastases. There has never been a death caused by benign or borderline tumour. Conclusion: The 10 mm resection margin is unachievable in our conditions. However, it seems that such radicality is not necessary in benign tumours, because they rarely recur even with close margins. Conversely, neither total mastectomy of the malignant phyllodes tumours will protect against local progression or distant metastasis.

scholarly journals Vaikų priekinio tarpuplaučio navikų ir displazijų chirurginis

2007 ◽  
Vol 5 (3) ◽  
pp. 0-0
Author(s):  
Stanislovas Jonas Maknavičius ◽  
Benjaminas Siaurusaitis ◽  
Arūnas Valiulis
Keyword(s):  
Surgical Treatment ◽  
Respiratory Distress ◽  
Myasthenia Gravis ◽  
Clinical Symptoms ◽  
Malignant Tumors ◽  
Diagnostic Methods ◽  
Benign Tumors ◽  
Histological Structure ◽  
Malignant Tumours ◽  
Mediastinal Tumours

Stanislovas Jonas Maknavičius, Benjaminas Siaurusaitis, Arūnas ValiulisVilniaus universiteto Vaikų ligoninės Vaikų chirurgijos centras,Santariškių g. 7, LT-08406 VilniusEl paštas: [email protected] Įvadas / tikslas Vaikų priekinio tarpuplaučio navikai ir displazijos yra dažnesni nei plaučių/bronchų navikai. Jie yra embrioninės kilmės, labai įvairios histologinės struktūros. Iki operacijos jų diferencinė diagnostika yra sunki, ji patikslinama atlikus naviko biopsiją ir histologinį tyrimą. Literatūroje diskutuojama dėl operacinio pjūvio, operacijų apimties. Ypač daug neaiškumų yra analizuojant užkrūčio liaukos patologiją. Mūsų tyrimo tikslas – panagrinėti vaikų priekinio tarpuplaučio navikų ir displazijų įvairovę, aptarti diagnostikos ir chirurginio gydymo taktiką. Ligoniai ir metodai Retrospektyviai analizavome 73 vaikų, gydytų 1985–2006 metais Vilniaus universiteto Vaikų ligoninės 1-ajame chirurgijos skyriuje dėl priekinio tarpuplaučio navikų ir displazijų, ligos istorijas, operacijų protokolus, tyrimų duomenis. Ligoniai buvo tirti klinikiniais metodais, atlikti navikinių žymenų tyrimai, acetilcholino antikūnų kiekio tyrimas, rentgenogramos (ir su kontrastuota stemple), kompiuterinės tomogramos, echoskopija, angiogramos, aortogramos. Rezultatai Iš mūsų gydytų ligonių 45-iems nustatyti nepiktybiniai navikai ir displazijos, o 28-iems – piktybiniai navikai. Navikai dažniausiai lokalizavosi užkrūčio liaukoje (48 ligoniams), ne užkrūčio liaukoje (25 ligoniams). Kvėpavimo takų distreso ir kompresijos simptomai buvo 58 ligoniams (79,5%) ir visiems vaikams iki 3 metų. Myasthenia gravis simptomai buvo 11 vaikų, iš jų 7 sirgo sunkia forma. Tiksliai diagnozei nustatyti buvo atliekama naviko biopsija ir histologinis tyrimas. Visos displazijos, nepiktybiniai, solidiniai piktybiniai navikai ir ribotos limfomos pašalinti operaciniu būdu. Šešiems ligoniams, sirgusiems Hodžkino ir ne Hodžkino limfoma, atlikta tik židinio biopsija. Išvados Svarbiausias priekinio tarpuplaučio navikų klinikinis simptomas yra kvėpavimo distresas, rečiau būna karščiavimas ir myasthenia gravis sindromas. Šis sindromas būdingas tikrajai užkrūčio liaukos hiperplazijai, limfoidinei hiperplazijai bei timomoms. Priekinio tarpuplaučio navikai ir displazijos yra labai įvairūs. Diagnozei patikslinti atliekama biopsija ir histologinis tyrimas. Visus nepiktybinius navikus, displazijas, solidinius piktybinius navikus bei ribotas limfomas reikia šalinti tik nustačius diagnozę. Pagrindiniai žodžiai: vaikų priekinio tarpuplaučio navikai, užkrūčio liaukos navikai, chirurginis gydymas Surgical treatment of anterior mediastinal tumours and dysplasias in children Stanislovas Jonas Maknavičius, Benjaminas Siaurusaitis, Arūnas ValiulisVilnius University Children’s Hospital, Centre of the Pediatric Surgery,Santariškių str. 7, LT-08406 Vilnius, LithuaniaE-mail: [email protected] Background / objective Anterior mediastinal tumours and dysplasias are more common than pulmonary – bronchial tumours in children. They differ in histological structure. In children, the differential diagnosis and surgical treatment of mediastinal tumours and dysplasias are very difficult. The aim of this study was to analyse the diagnostic methods of various tumours and dysplasias and the tactics of surgical treatment. Patients and methods We analysed retrospectively 73 children‘s cases histories with anterior mediastinal tumours and dysplasias from the period 1985–2006. Clinical symptoms, histological diagnosis and methods of surgical treatment were analysed. Results Forty-five patients had benign tumors and dysplasias and 28 patients had malignant tumours. Thymic gland pathology was found in 48 patients. Respiratory distress syndrome was have diagnosed in 58 cases (79.5%). All children under 3 years had severe respiratory symptoms. Myasthenia gravis was present in 11 cases. Our data are based on histological analysis after biopsy or operation. All dysplasias, benign tumours, solid malignant tumours and local lymphomas were operated on and removed. Conclusions Anterior mediastinal tumours and dysplasias differed in histological structure. The most frequent symptom was respiratory distress, rare symptoms were fever or myasthenia gravis. All dysplasias, benign and solid malignant tumors and localised lymphomas were operated on and removed when the diagnosis had been confirmed. Keywords: anterior mediastinal tumours in children, thymic gland tumours, surgical treatment

Medulloblastoma

2019 ◽  
pp. 353-360
Author(s):  
James Rutka
Keyword(s):  
Surgical Treatment ◽  
Side Effects ◽  
Significant Variation ◽  
Survival Rates ◽  
Molecular Targets ◽  
Malignant Neoplasms ◽  
Malignant Tumours ◽  
Who Grade ◽  
The Common ◽  
Embryonal Tumours

Under the term embryonal tumours, we examine the malignant neoplasms medulloblastomas, CNS-PNETs, AT/RTs, and ETANTRs. The common histological link between them is the small, round, blue cells which appear on H&E stains. They are considered highly malignant tumours (WHO Grade IV), although significant variation of prognosis exists between the different subtypes. Current classification is based on their histopathological features. Advances on understanding of the molecular biology and behaviour of their cellular lines, has dramatically changed their stratification and scientific approach. Combination of surgical treatment with new schemes of adjuvant chemo- and radiotherapy offers improved survival rates but comes with a high cost on neurocognitive, endocrine, and overall functional status. New therapies with molecular targets will hopefully improve outcomes with minimal side effects and collateral damage.

scholarly journals Influence of surgical treatment of selected malignant tumours on gait kinematics – a pilot study

2018 ◽  
Vol 26 (4) ◽  
pp. 33-39
Author(s):  
Anna Latajka ◽  
Marek Woźniewski ◽  
Iwona Malicka
Keyword(s):  
Surgical Treatment ◽  
Pilot Study ◽  
Malignant Tumours ◽  
Gait Kinematics
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