Primary neonatal thalamic haemorrhage and epilepsy with continuous spike-wave during sleep: a longitudinal follow-up of a possible significant relation

2001 ◽  
Vol 5 (1) ◽  
pp. 41-47 ◽  
Author(s):  
José Paulo Monteiro ◽  
Eliane Roulet-Perez ◽  
Veronique Davidoff ◽  
Thierry Deonna
Keyword(s):  
Significant Relation ◽  
Thalamic Haemorrhage ◽  
Spike Wave

scholarly journals Adverse reactions to oxacillin in hospitalized children: a prospective study

2007 ◽  
Vol 7 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Mariana de Oliveira Brizeno de Souza ◽  
Maria da Conceição Castro de Araújo ◽  
Raquel Araújo de Santiago ◽  
Helena Lutéscia Luna Coelho ◽  
Marta Maria de França Fonteles
Keyword(s):  
Exposure Time ◽  
Treatment Duration ◽  
Adverse Reactions ◽  
Therapeutic Interventions ◽  
Hospitalized Children ◽  
Significant Relation ◽  
Moderate Severity ◽  
A Prospective Study ◽  
Established Treatment

OBJECTIVES: follow-up of children exposed to oxacillin during hospitalization focusing on adverse reactions. METHODS: patients were selected from the pediatric wards of two hospitals in Fortaleza (Hospital Universitário Walter Cantídio-HUWC and Hospital Infantil Albert Sabin-HIAS) from the first oxacillin prescription with a prospective cohort study between October, 2000 and July, 2001 (HUWC) and July/2001 and March, 2002 (HIAS). Patients' follow-up was performed by daily visits to the wards and medical charts and prescription analysis. Suspected oxacillininduced adverse reactions (OxAR cases) were notified and classified according to causality and severity. Related statistic tests were completed. RESULTS: of the 130 patients exposed to oxacillin, 27 had OxAR (20.8%). Fever was the most frequent reaction (50%) followed by rash (35.7%). The majority of reactions were considered Probable, for oxacillin was the only medication involved and 92.6% of the cases had Moderate severity with the need of therapeutic interventions caused by OxAR. A significant relation between oxacillin exposure time and OxAR was determined as well as hospitalization time and the appearance of adverse reactions. Exposure time over 14 days to oxacillin was established as a risk factor for OxAR (relative risk = 5.49). CONCLUSIONS: careful administration of oxacillin in children is recommended with established treatment duration. Empiric and prolonged use must be avoided.

scholarly journals Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy

2018 ◽  
Vol 46 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Anita N. Datta ◽  
Laura Wallbank ◽  
Peter K. H. Wong
Keyword(s):  
Clinical Data ◽  
Seizure Control ◽  
Age Of Onset ◽  
Absence Epilepsy ◽  
Childhood Absence Epilepsy ◽  
Drug Induced ◽  
Favorable Prognosis ◽  
Spike Wave Discharges ◽  
Spike Wave

AbstractObjectiveBenign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features.MethodsAll EEGs at BC Children’s Hospital are entered in a database, which include EEG findings and clinical data. Patients with both centro-temporal spikes and 3 Hz GSW discharges were identified from the database and clinical data were reviewed.ResultsAmong the 43,061 patients in the database from 1992 to 2017, 1426 with isolated rolandic discharges and 528 patients with isolated 3 Hz GSW discharges were identified, and 20 (0.05%) patients had both findings: 3/20 had BECTS, and subsequently developed childhood absence epilepsy and 17/20 had no seizures characteristic for BECTS. At follow-up, 17 (85%) were seizure-free, 1 (5%) had rare, and 2 (10%) had frequent seizures.ConclusionsThis is the largest reported group of patients to our knowledge with the co-existence of rolandic and 3 Hz GSW discharges on EEGs in one institution, not drug-induced. As the presence of both findings is extremely rare, distinct pathophysiological mechanisms are likely. The majority had excellent seizure control at follow-up, similar to what would be expected for each type of epilepsy alone.

scholarly journals Evaluation of laboratory markers of progression of HIV disease to death

2011 ◽  
Vol 44 (6) ◽  
pp. 657-660 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Maria do Desterro Soares Brandão Nascimento ◽  
Aila de Menezes Ferreira ◽  
Érica Milena Fernandes Rabelo ◽  
João Arnaud Diniz Neto ◽  
...  
Keyword(s):  
Viral Load ◽  
Hiv Disease ◽  
Significant Relation ◽  
Chi Square ◽  
Laboratory Markers ◽  
Cd4 Lymphocyte Count ◽  
Chi Square Test ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

scholarly journals Presence, Cybersickness, Anxiety, and Heart Rate Variability in a Non-Clinical Population Using Virtual Reality Environments Designed For Specific Phobias' Treatment

2020 ◽  
Vol 4 (1) ◽  
pp. 01-09
Author(s):  
Maria Jose Distefano ◽  
Lucas P. Labandeira ◽  
Fernando M. Tarnogol ◽  
Belen Mesurado
Keyword(s):  
Virtual Environments ◽  
State Anxiety ◽  
Clinical Population ◽  
Simulator Sickness ◽  
State Trait Anxiety Inventory ◽  
Significant Relation ◽  
Future Studies ◽  
Follow Up Study ◽  
Autonomic Activation

The current study was performed to assess the phenomenon known as Presence, to measure Anxiety responses, simulator sickness and autonomic activation in subjects of the general population. The sample consisted in 37 Argentine participants (15 male, 22 female) between ages 20 and 40; who were exposed to 3 virtual environments designed to research and treat phobias. Instruments utilized for this study were the Symptom Checklist 90-R, Acrophobia Questionnaire, Fear of Spiders Questionnaire, The Claustrophobia Questionnaire, Igroup Presence Questionnaire, Simulator Sickness Questionnaire and the State-Trait Anxiety Inventory. All virtual environments generated sufficient feeling of presence. Cybersickness was only registered in the Elevator scenario. The Apartment and Spiders environments have shown not to be anxiety triggers within this population. As for Elevator, a significant increase in the level of state anxiety was generated. A possible hypothesis to account for this fact might be that reported anxiety responds to movement simulated in the virtual scenario while on the other two scenarios the subjects remained static. The existence of a correlation between HRV and state anxiety has been analyzed and no significant relation has been found between the variables. Even though there is a relation between anxiety and presence, no significant relation has been found between anxiety and presence. Regarding sensory conflict, a follow up study in the Elevator environment should be done, eliminating movement and exposing subjects to the stimuli while static at different heights. Future studies should consider broadening the size of the sample and studying clinical population to compare results.

Course of cognitive decline in Parkinson's disease: A meta-analysis

2007 ◽  
Vol 13 (6) ◽  
pp. 920-932 ◽  
Author(s):  
DINO MUSLIMOVIĆ ◽  
BEN SCHMAND ◽  
JOHANNES D. SPEELMAN ◽  
ROB J. DE HAAN
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Ability ◽  
Educational Level ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Neuropsychological Performance ◽  
Significant Relation ◽  
Cognitive Domains

A meta-analysis was conducted on 25 longitudinal studies involving 901 initially non-demented Parkinson's disease (PD) patients to examine the magnitude of decline across multiple cognitive domains associated with disease progression. Pooled effect sizes reflecting the standardized difference between baseline and follow-up neuropsychological performance were calculated for 8 cognitive domains using a random-effects model. Relatively small effect sizes were found across all cognitive domains (d= .00 − .40). During a mean follow-up interval of 29 months, significant declines were detected in global cognitive ability (d= .40), visuoconstructive skills (d= .32), and memory (d= .29). Age showed a significant relation with decline in global cognitive ability and memory. Lower educational level was associated with greater decline in all cognitive domains. Studies with longer follow-up intervals yielded larger effect sizes for global cognitive ability. In non-demented PD patients, changes in cognitive functions over time appear to be modest. Educational level, age, and length of the follow-up interval are likely to affect the magnitude of decline in several domains. Methodological flaws, such as selection bias and uncontrolled practice effects, may have caused underestimation of the true extent of decline (JINS, 2007,13, 920–932.)

scholarly journals Psychosis and Violence: Stories, Fears, and Reality

2008 ◽  
Vol 53 (10) ◽  
pp. 647-659 ◽  
Author(s):  
Pamela J Taylor
Keyword(s):  
Literature Search ◽  
Cochrane Library ◽  
Significant Relation ◽  
Manual Search ◽  
Violent Acts ◽  
Victims Of Violence ◽  
Almost All ◽  
The Cochrane Library ◽  
Substantial Change

Individuals with psychosis are often feared. In fact, they are themselves likely to be victims of violence; however, the main aim of this review is to provide an overview of the evidence on relations between psychosis and violence to others. The terms psychosis and violence were used in a literature search limited to the Cochrane Library and PubMed, a manual search of 8 journals, and a follow-up of additional references in the articles found. The overview draws on new empirical data and major reviews. Almost all sound epidemiologic data on psychosis and violence dates from 1990. There is consistency on a small but significant relation between schizophrenia and violent acts. Since then there has also been movement toward understanding the nature of associations and progress on strategies for managing individuals who have psychosis and are violent. Public fears about individuals with psychotic illnesses are largely unfounded, although there would be benefit in greater attention to the safety of those in their close social circle. The task for the next 10 years must be the development and application of knowledge to improve specific treatments—that is, interventions that go beyond holding and caring to bring about substantial change.

scholarly journals Language aspects of children infected with HIV

Revista CEFAC ◽  
2013 ◽  
Vol 15 (6) ◽  
pp. 1621-1626 ◽  
Author(s):  
Raphaela Barroso Guedes Granzotti ◽  
Silvia Fabiana Biason de Moura Negrini ◽  
Marisa Tomoe Hebihara Fukuda ◽  
Osvaldo Massaiti Takayanagui
Keyword(s):  
Early Stage ◽  
Clinical Classification ◽  
Significant Relation ◽  
Immunological Parameters ◽  
Clinical Criteria ◽  
Immunological Profile ◽  
Viral Burden ◽  
Study Population

PURPOSE: to assess the lexical proficiency and the incidence of phonologic disorders in the language of children infected with HIV. METHOD: the study population consisted of 31 children between three and seven year-old. For evaluation purposes the Test of Infantile Language - ABFW was applied in the areas of phonology and vocabulary. RESULTS: the results obtained were analyzed according to the clinical criteria for the classification of the disease proposed by the CDC and regarding the immunological profile and the viral burden using the Mann-Whitney test for statistical analysis. In the vocabulary evaluation, 100% of the children presented an inappropriate response for their age in at least two distinct conceptual fields. In the phonologic evaluation, 67.7% of the assessed children were considered to be affected by some phonologic disorder. When we compared adequate and inadequate results of phonologic evaluation to the clinical and immunological parameters of AIDS such as clinical classification (p=0,16), CD4 count (p=0,37) and viral burden (p=0,82), we did not detect a statistically significant relation between language alterations and disease severity. CONCLUSION: this research has shown that the studied group presents a high risk for language disorders and that constant phonoaudiological follow-up is essential to identify the alterations in early stage.

scholarly journals Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Juliano Coelho de Oliveira Zakir ◽  
Luiz Augusto Casulari ◽  
José Wilson Corrêa Rosa ◽  
João Willy Corrêa Rosa ◽  
Paulo Andrade de Mello ◽  
...  
Keyword(s):  
Pituitary Tumors ◽  
Biological Behavior ◽  
Significant Relation ◽  
Ki 67 ◽  
Radiological Features ◽  
Current Classification ◽  
Geographical Cluster

Although some pituitary adenomas may have an aggressive behavior, the vast majority are benign. There are still controversies about predictive factors regarding the biological behavior of these particular tumors. This study evaluated potential markers of invasion and proliferation compared to current classification patterns and epidemiogeographical parameters. The study included 50 patients, operated on for tumors greater than 30 mm, with a mean postoperative follow-up of 15.2 ± 4.8 years. Pituitary magnetic resonance was used to evaluate regrowth, invasion, and extension to adjacent tissue. Three tissue biomarkers were analyzed: p53, Ki-67, and c-erbB2. Tumors were classified according to a combination of histological and radiological features, ranging from noninvasive and nonproliferative (grade 1A) to invasive-proliferative (grade 2B). Tumors grades 2A and 2B represented 42% and 52%, respectively. Ki-67 (p=0.23) and c-erbB2 (p=0.71) had no significant relation to tumor progression status. P53 (p=0.003), parasellar invasion (p=0.03), and classification, grade 2B (p=0.01), were associated with worse clinical outcome. Parasellar invasion prevails as strong predictive factor of tumor recurrence. Severe suprasellar extension should be considered as invasion parameter and could impact prognosis. No environmental factors or geographical cluster were associated with tumor behavior.

Oral Acetazolamide Administration to Control Intraocular Pressure on First Day Post Phacoemulsification Surgery : Is It Necessary ?

2019 ◽  
Vol 43 (2) ◽  
pp. 118
Author(s):  
Reinne Natali Christine ◽  
Henricus Datu Respatika ◽  
Gilbert Simanjuntak
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Oral Administration ◽  
Descriptive Study ◽  
Nuclear Density ◽  
Significant Relation ◽  
History Of ◽  
Iop Elevation ◽  
The Relationship

Introduction : The incidence of early postoperative intraocular pressure (IOP) increase is reported to be 2.3–8.9% in phacoemulsification surgery. This increase typically peaks at 3–7 hours after surgery and persists during the first 24 hours. Although most eyes can tolerate the transient IOP elevation that occurs after cataract surgery, IOP spikes are potentially more dangerous if it persist. In order to minimize postoperative intraocular pressure (IOP) rise, routine medication by oral acetazolamide has been widely used among ophthalmologists. Objective of this study is to investigate the relationship between IOP changes on first day after phacoemulsification with administration of oral acetazolamide. Method : This is a descriptive study. The samples were include 50 patients diagnosed with cataract who underwent phacoemulsification surgery with intraocular lens implantatios. Samples were randomized divided into two groups. First group is patient who treated with 250 mg acetazolamide post operative and other group is untreated. All respondents must have no history of glaucoma or ocular hypertensive and attend follow up on the first day postoperative. IOP is measured with non-contact tonometer. Results : Mean age of respondents is 61  9.8 years old. Preoperative IOP mean is 18.04  3.6 mmHg and postoperative IOP mean is 18.58  6.9 mmHg. This study revealed that there is no significant relation between oral administration of acetazolamide and the lowering of intraocular pressure on first day post phacoemulsification(p = 0.2) Visual acuity pre operative and nuclear density of cataract are also no relationship with the IOP on first day postoperative (p = 0.2 ) Conclusion : The use of oral acetazolamide is not significantly related to the IOP on first day post phacoemulsification surgery.

Clinical drivers for imaging testing in nonmetastatic castration-resistant prostate cancer: May they be optimized?—Data of “IDENTIFICA” study.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 318-318
Author(s):  
Eduardo Useros RodrÃguez ◽  
Álvaro Juárez ◽  
Joaquín Carballido Rodríguez ◽  
Jose Rubio ◽  
Alfredo Rodríguez Antolín ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Critical Event ◽  
Castration Resistant Prostate Cancer ◽  
Significant Relation ◽  
Curative Intent ◽  
Castration Resistant ◽  
Disease Characteristics ◽  
Relevant Factors ◽  
Rule Out

318 Background: Metastases (M+) detection is a critical event in non-metastatic castration-resistant prostate cancer (nmCRPC), as it entails a change in PC management and is a potential surrogate for survival at this stage. PSA doubling time (PSA-DT) has been described as a prognostic factor to develop M+. However, there could be other relevant factors to raise suspicion of progression in nmCRPC patients. The “IDENTIFICA” study tries to describe disease characteristics and clinical drivers that make physicians suspect the presence of M+ in nmCRPC patients in clinical practice in Spain. Methods: Observational, transversal, multicenter study. nmCRPC patients with physician’s suspiction of M+ were selected. Imaging tests to rule out metastases were requested; clinical drivers were described, along with clinical data related to prostate cancer (PC). Results: 197 nmCRPC patients were recruited (Jan-Jun 2018). Median age was 81.3 years. Median time from the onset of androgen deprivation therapy (ADT) to CRPC was 5.1 years (IQR: 2.5-8.2). ADT was the first PC treatment for 64.4% of , while 41.2% went through a curative-intent treatment. Median PSA-DT at CRPC diagnosis was 7.5 months. Time from PC diagnosis to CRPC was influenced by Gleason score at diagnosis ( p=0.001), primary curative intent treatment ( p<0.001), and PSA-DT at CRPC diagnosis ( p=0.04). Most important clinical drivers leading physicians to request imaging were PSA value, PSA-DT and PC guidelines recommendations. M+ were detected in 23 patients (16.5%). In the multivariate analysis, there was a statistically significant relation between positive imaging and time on ADT (OR 1.16; 95% CI 1.018-1.325; p=0.026) and time on CRPC status (OR 1.55; 95% CI 1.038-2.302; p=0.032). In this interim analysis, PSA and PSA-DT seemed not to be statistically related to M+ appearance. Conclusions: PSA and PSA-DT seem to be the most influential drivers to request imaging tests during follow-up of nmCRPC patients. Time on ADT and time on CRPC status could be relevant factors for M+ detection and phycisians should be aware of them and not just PSA or PSADT to properly ask for imaging tests.

Sign in / Sign up

Export Citation Format

Share Document