Accelerated Radiation Therapy, Seven Fractions Per Week, For Advanced Head And Neck Cancer–A Feasibility Study

2002 ◽  
Vol 14 (3) ◽  
pp. 236-240 ◽  
Author(s):  
Joe M. O'Sullivan ◽  
Donal P. Hollywood ◽  
Nuala Cody ◽  
Joe Dillon ◽  
Steve Buckney ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Feasibility Study ◽  
Neck Cancer ◽  
Advanced Head ◽  
Accelerated Radiation Therapy

Hyperfractionated Accelerated Chemoradiation With Concurrent Fluorouracil-Mitomycin Is More Effective Than Dose-Escalated Hyperfractionated Accelerated Radiation Therapy Alone in Locally Advanced Head and Neck Cancer: Final Results of the Radiotherapy Cooperative Clinical Trials Group of the German Cancer Society 95-06 Prospective Randomized Trial

2005 ◽  
Vol 23 (6) ◽  
pp. 1125-1135 ◽  
Author(s):  
Volker Budach ◽  
Martin Stuschke ◽  
Wilfried Budach ◽  
Michael Baumann ◽  
Dirk Geismar ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head ◽  
Cancer Society ◽  
Secondary Neoplasms ◽  
Randomized Clinical Study ◽  
Accelerated Radiation Therapy

Purpose To report the results and corresponding acute and late reactions of a prospective, randomized, clinical study in locally advanced head and neck cancer comparing concurrent fluorouracil (FU) and mitomycin (MMC) chemotherapy and hyperfractionated accelerated radiation therapy (C-HART; 70.6 Gy) to hyperfractionated accelerated radiation therapy alone (HART; 77.6 Gy). Patients and Methods Three hundred eighty-four stage III (6%) and IV (94%) oropharyngeal (59.4%), hypopharyngeal (32.3%), and oral cavity (8.3%) cancer patients were randomly assigned to receive either 30 Gy (2 Gy every day) followed by 1.4 Gy bid to a total of 70.6 Gy concurrently with FU (600 mg/m2, 120 hours continuous infusion) days 1 through 5 and MMC (10 mg/m2) on days 5 and 36 (C-HART) or 14 Gy (2 Gy every day) followed by 1.4 Gy bid to a total dose of 77.6 Gy (HART). The data were analyzed on an intent-to-treat basis. Results At 5 years, the locoregional control and overall survival rates were 49.9% and 28.6% for C-HART versus 37.4% and 23.7% for HART, respectively (P = .001 and P = .023, respectively). Progression-free and freedom from metastases rates were 29.3% and 51.9% for C-HART versus 26.6% and 54.7% for HART, respectively (P = .009 and P = .575, respectively). For C-HART, maximum acute reactions of mucositis, moist desquamation, and erythema were lower than with HART, whereas no differences in late reactions and overall rates of secondary neoplasms were observed. Conclusion C-HART (70.6 Gy) is superior to dose-escalated HART (77.6 Gy) with comparable or less acute reactions and equivalent late reactions, indicating an improvement of the therapeutic ratio.

A phase II study of docetaxel and carboplatin with concurrent radiation therapy for locally advanced head and neck cancer

2011 ◽  
Vol 38 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Imjai Chitapanarux ◽  
Vicharn Lorvidhaya ◽  
Ekasit Tharavichitkul ◽  
Somvilai Mayurasakorn ◽  
Pichit Sittitrai ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Advanced Head
Sign in / Sign up

Export Citation Format

Share Document