Reconstitution of T-cell repertoire after autologous stem cell transplantation: Influence of CD34 selection and cytomegalovirus infection

2003 ◽  
Vol 9 (3) ◽  
pp. 198-205 ◽  
Author(s):  
Karl S. Peggs ◽  
Stephanie Verfuerth ◽  
Arnold Pizzey ◽  
Naeem Khan ◽  
Paul Moss ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Cytomegalovirus Infection ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Cd34 Selection

scholarly journals T cell repertoire following autologous stem cell transplantation for multiple sclerosis

2014 ◽  
Vol 124 (3) ◽  
pp. 1168-1172 ◽  
Author(s):  
Paolo A. Muraro ◽  
Harlan Robins ◽  
Sachin Malhotra ◽  
Michael Howell ◽  
Deborah Phippard ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
T Cell Repertoire ◽  
Cell Repertoire

scholarly journals Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation

2013 ◽  
Vol 19 (3) ◽  
pp. 372-377 ◽  
Author(s):  
Jeroen W J van Heijst ◽  
Izaskun Ceberio ◽  
Lauren B Lipuma ◽  
Dane W Samilo ◽  
Gloria D Wasilewski ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Quantitative Assessment ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hematopoietic Stem

Resetting of the Mucosal T Cell Repertoire after Hematopoietic Stem Cell Transplantation in Refractory Crohn’s Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S613-S614 ◽  
Author(s):  
Lionel Le Bourhis ◽  
Ana Maria Corraliza ◽  
Claire Auzolle ◽  
Elena Ricart ◽  
Christopher J. Hawkey ◽  
...  
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hematopoietic Stem

scholarly journals Reconstitution of T cell immunity against EBV in the immunocompromised host by adoptive transfer of peptide-stimulated T cells after allogeneic stem cell transplantation

2021 ◽  
Author(s):  
María Fernanda Lammoglia Cobo ◽  
Julia Ritter ◽  
Regina Gary ◽  
Volkhard Seitz ◽  
Josef Mautner ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Adoptive Transfer ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Cell Immunity

Reconstitution of T cell repertoire after allogeneic stem cell transplantation is a long and often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent complication that may be treated by adoptive transfer of donor-derived EBV-specific T cells. We generated donor-derived EBV-specific T cells by peptide stimulation and adoptively transferred them to a patient with angioimmunoblastic T-cell lymphoma (AITL), who had developed persisting high titers of EBV concomitant to relapse after transplantation. T cell receptor beta (TCRβ) deep sequencing showed that the T cell repertoire of the patient early after transplantation (day 60) was strongly reduced and only very low numbers of EBV-specific T cells were detectable. Manufacturing and in vitro expansion of donor-derived EBV-specific T cells resulted in enrichment of EBV epitope-specific, HLA-restricted T cells. Monitoring after adoptive transfer revealed that the dominant TCR sequences from peptide-stimulated T cells persisted long-term and established an EBV-specific TCR clonotype repertoire in the host, with many of the EBV-specific TCRs present in the donor. This reconstituted repertoire was associated with immunological control of EBV and with lack of further AITL relapse.

scholarly journals Fractal Organization of the Human T Cell Repertoire in Health and after Stem Cell Transplantation

2013 ◽  
Vol 19 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Jeremy Meier ◽  
Catherine Roberts ◽  
Kassi Avent ◽  
Allison Hazlett ◽  
Jennifer Berrie ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Fractal Organization ◽  
Human T Cell
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