Acquired posterior choanal stenosis and atresia: Management of this unusual complication after radiotherapy for nasopharyngeal carcinoma

2001 ◽  
Vol 22 (4) ◽  
pp. 225-229 ◽  
Author(s):  
Peter K.M. Ku ◽  
Michael C.F. Tong ◽  
S.S. Tsang ◽  
Andrew van Hasselt
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Unusual Complication ◽  
Choanal Stenosis

scholarly journals Choanal stenosis post radiotherapy for nasopharyngeal carcinoma: about an endoscopic management

2019 ◽  
Vol 34 ◽  
Author(s):  
Youssef Lakhdar ◽  
Sara Rochd ◽  
Mohamed Elbouderkaoui ◽  
Youssef Rochdi ◽  
Hassan Nouri ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Endoscopic Management ◽  
Choanal Stenosis

scholarly journals Dosimetric parameters predict radiation-induced choanal stenosis in patients with nasopharyngeal carcinoma

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hui Chang ◽  
Kai Chen ◽  
Ya-lan Tao ◽  
Fei Han ◽  
Wei-jun Ye ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Radiation Induced ◽  
Choanal Stenosis

Application of holmium yttrium aluminium garnet (YAG) laser in treatment of acquired posterior choanal atresia following radiotherapy for nasopharyngeal carcinoma

2006 ◽  
Vol 121 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Peter K M Ku ◽  
Michael C F Tong ◽  
Andrew van Hasselt
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Choanal Atresia ◽  
Yttrium Aluminium Garnet ◽  
Unusual Complication ◽  
External Radiotherapy ◽  
Yag Laser ◽  
Laser Resection ◽  
Yttrium Aluminium ◽  
The Mean

Aims: To report on the use of holmium yttrium aluminium garnet (YAG) laser in the treatment of acquired posterior choanal atresia following radiotherapy in patients with nasopharyngeal carcinoma.Materials and methods: Five patients with acquired bilateral choanal atresia and two with unilateral choanal atresia in the posterior choanae were identified following treatment of nasopharyngeal carcinoma by external radiotherapy, from July 1998 to April 1999. The mean age was 44.6 years (range, 22–65 years). Two patients had stage two and five had stage three disease according to Ho's classification. All patients received 66 Gy of external irradiation delivered to the nasopharynx and a mean dose of 61 Gy (39.8–72 Gy) to the neck. Five patients received an additional external boost of 20 Gy and two received 14 Gy delivered to the parapharyngeal region. Two other patients also received intracavitatory brachytherapy of 18 Gy delivered to the nasopharynx. One patient had concurrent chemotherapy by cisplatinum during external radiotherapy. The mean onset of nasal symptoms was 17 months (range, 2–38 months) following irradiation. All patients were treated by transnasal endoscopic holmium YAG laser resection. Merocel® epistaxis packing and a modified nasopharyngeal tube were used to stent the nasal airway for two weeks post-operatively.Results: The mean follow up was 26.8 months (range, 20–32 months) after surgery. All patients were symptom free on follow up. Five patients (71 per cent) retained full patency in the posterior choanae. Two patients (28 per cent) had bilateral mild restenosis in the postnasal space, not requiring revision surgery. The surgical fields were almost bloodless. No adverse post-operative complications occurred, except for delayed nasal septal perforation in one patient and unilateral exposure of the septal cartilage in another; no further treatment was required in either patient.Conclusion: Acquired posterior choanal atresia is an unusual complication following radiotherapy, and it can occur early after treatment. It can be successfully treated by transnasal endoscopic holmium YAG laser resection of the scar tissue, with minimal bleeding. A two week period of Merocel® nasal packing and nasopharyngeal tube stenting was sufficient to prevent severe restenosis in the posterior choanae; nasal breathing through the tube lumen was possible during this time.

Velopharyngeal and choanal stenosis after radiotherapy for nasopharyngeal carcinoma

2013 ◽  
Vol 40 (3) ◽  
pp. 323-326 ◽  
Author(s):  
Jalal Hussein ◽  
Teck Soon Tan ◽  
Aun Wee Chong ◽  
Prepageran Narayanan ◽  
Rahmat Omar
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Choanal Stenosis

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

1975 ◽  
Vol 33 ◽  
pp. 342-343
Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau
Keyword(s):  
Electron Microscopy ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
If Technique ◽  
Infected Cells ◽  
Virus Antigens ◽  
Epstein Barr ◽  
Virus Capsid Antigen ◽  
Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

Sign in / Sign up

Export Citation Format

Share Document