Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients

2002 ◽  
Vol 40 (6) ◽  
pp. 1283-1288 ◽  
Author(s):  
Daniel W. Coyne ◽  
Marvin Grieff ◽  
Shubhada N. Ahya ◽  
Karla Giles ◽  
Kathy Norwood ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Vitamin D3 ◽  
Hemodialysis Patients ◽  
Acute Administration ◽  
Vitamin D2 ◽  
Differential Effects ◽  
Calcium And Phosphorus ◽  
1,25 Dihydroxy Vitamin D3

scholarly journals Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial

2019 ◽  
Vol 104 (12) ◽  
pp. 5831-5839 ◽  
Author(s):  
Adrian R Martineau ◽  
Kenneth E Thummel ◽  
Zhican Wang ◽  
David A Jolliffe ◽  
Barbara J Boucher ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Bolus Dose ◽  
Total Serum ◽  
Vitamin D2 ◽  
Serum Concentrations ◽  
Vitamin D Metabolism ◽  
Dihydroxyvitamin D3 ◽  
Differential Effects ◽  
The Mean

Abstract Context Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism. Objective To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3. Methods We measured baseline and 4-month serum concentrations of vitamin D3, 25-hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2, 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3], 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], and 4β,25-dihydroxyvitamin D3 [4β,25(OH)2D3] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D2 (n = 28) or vitamin D3 (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of vitamin D2 and vitamin D3 on metabolism of vitamin D. Mean postsupplementation metabolite-to-parent ratios were then compared between groups. Results Vitamin D2 was less effective than vitamin D3 in elevating total serum 25(OH)D concentration. Vitamin D2 suppressed mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and mean ratios of 25(OH)D3 to D3 and 1α,25(OH)2D3 to 25(OH)D3, while increasing the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Vitamin D3 increased mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Participants receiving vitamin D2 had lower mean postsupplementation ratios of 25(OH)D3 to vitamin D3 and 1α,25(OH)2D3 to 25(OH)D3 than those receiving vitamin D3. Mean postsupplementation ratios of 24R,25(OH)2D3 to 25(OH)D3 and 4β,25(OH)2D3 to 25(OH)D3 did not differ between groups. Conclusions Bolus-dose vitamin D2 is less effective than bolus-dose vitamin D3 in elevating total serum 25(OH)D concentration. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3.

scholarly journals Serum Calcium and Phosphorus Levels in Hemodialysis Patients: A Large Population-Based Multicenter Study

2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mohsen Nafar ◽  
Tahereh Sabaghian ◽  
Alireza Khoshdel ◽  
Behrang Alipour ◽  
Shiva Samavat
Keyword(s):  
Serum Calcium ◽  
Multicenter Study ◽  
Large Population ◽  
Population Based ◽  
Hemodialysis Patients ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels

Differential effects of vitamin D3 vs vitamin D2 on cellular uptake, tissue distribution and activation of vitamin D in mice and cells

2020 ◽  
Vol 204 ◽  
pp. 105768
Author(s):  
Anja C. Baur ◽  
Corinna Brandsch ◽  
Benita Steinmetz ◽  
Alexandra Schutkowski ◽  
Monika Wensch-Dorendorf ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tissue Distribution ◽  
Cellular Uptake ◽  
Vitamin D3 ◽  
Vitamin D2 ◽  
Differential Effects

scholarly journals A STUDY TO DETECT THE PROPORTION OF ALTERED SERUM CALCIUM, PHOSPHOROUS AND VITAMIN D3 LEVEL IN NEWLY DIAGNOSED PULMONARY TUBERCULOSIS PATIENTS ATTENDING CHEST OPD IN BURDWAN MEDICAL COLLEGE & HOSPITAL

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Rupam Kumar Ta ◽  
Debashree Mukherjee ◽  
Pronoy Sen
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Newly Diagnosed ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Calcium And Phosphorus

Introduction: Pulmonary Tuberculosis (PTB) is still a very common cause of morbidity & morbidity in India.[7] Calcium and phosphorus metabolism plays an important role in the healing of lesions in PTB. Vitamin D deficient individuals have a greater susceptibility to develop TB[14] and worse disease progression if infected with TB.[15] Due to paucity of studies this study was carried out to estimate the mean value of serum calcium phosphorous and Vitamin D3 level in newly diagnosed PTB patients and find out correlation among the altered values of these biochemical parameters. Methods: This was an observational cross sectional hospital based study carried out on 120 patients attending Burdwan Medical College over a period of one and a half years. All patients of PTB were included, while patients with Sarcoidosis, hepatitis, chronic kidney disease, post menopausal women were excluded from study. Serum Calcium, Phosphorus and Vitamin D3 were estimated in these patients. Data collected was entered in Excel Spreadsheet, and analysed in SPSS version 19.0 using descriptive statistical methods, percentiles and scatter diagrams. Main Findings: Serum calcium and phosphorus was not significantly decreased in our study. Moderate prevalence of vitamin D deficiency was found among newly diagnosed PTB patients. Significant correlation was found between altered vitamin D3, serum phosphorus and serum calcium level. Conclusion: Since Serum vitamin D3 is significantly decreased in pulmonary tuberculosis it is essential to monitor the serum levels of vitamin D3 in PTB patients and provide adequate supplementation of vitamin D3. Keywords: Pulmonary Tuberculosis, Calcium, Vitamin D3, Phosphorus

Vitamin D2 versus vitamin D3 supplementation in hemodialysis patients: a comparative pilot study

2012 ◽  
Vol 26 (1) ◽  
pp. 152-157 ◽  
Author(s):  
Maïté Daroux ◽  
Milhad Shenouda ◽  
Jean-Louis Bacri ◽  
Vincent Lemaitre ◽  
Philippe Vanhille ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vitamin D3 ◽  
Hemodialysis Patients ◽  
Vitamin D2 ◽  
Vitamin D3 Supplementation
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