Goodpasture's disease in the absence of circulating anti-glomerular basement membrane antibodies as detected by standard techniques

2002 ◽  
Vol 39 (6) ◽  
pp. 1162-1167 ◽  
Author(s):  
Alan D. Salama ◽  
Tammy Dougan ◽  
Jeremy B. Levy ◽  
H.Terry Cook ◽  
Steve H. Morgan ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Goodpasture's Disease ◽  
Goodpasture’S Disease ◽  
Standard Techniques

Two cases of anti-glomerular basement membrane (Goodpasture’s) disease in female adolescents

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Elena V Zakharova ◽  
Tatyana A Makarova ◽  
Zhanna V Sheikh ◽  
Hadyja M Emirova ◽  
Ekaterina S Stolyarevich
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Female Adolescents ◽  
Goodpasture's Disease ◽  
Goodpasture’S Disease

scholarly journals Atypical Goodpasture’s disease: a clinical case report and literature review

2018 ◽  
Vol 90 (6) ◽  
pp. 130-136 ◽  
Author(s):  
M L Bulanova ◽  
D V Potapov ◽  
N M Bulanov ◽  
L V Lysenko(Kozlovskaya)
Keyword(s):  
Basement Membrane ◽  
Renal Involvement ◽  
Rapidly Progressive Glomerulonephritis ◽  
Young Male ◽  
Alveolar Hemorrhage ◽  
Disease Course ◽  
Small Vessels ◽  
Goodpasture's Disease ◽  
Pulmonary Renal Syndrome ◽  
Goodpasture’S Disease

Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease.

Antiglomerular basement membrane disease

2010 ◽  
pp. 3995-4001
Author(s):  
Jeremy Levy ◽  
Charles Pusey
Keyword(s):  
Autoimmune Disease ◽  
Basement Membrane ◽  
Type Iv Collagen ◽  
Complement C3 ◽  
Terminal Domain ◽  
Type Iv ◽  
Goodpasture's Disease ◽  
Goodpasture’S Disease

Antiglomerular basement membrane disease (anti-GBM disease, also known as Goodpasture’s disease) is a rare autoimmune disease caused by pathogenic autoantibodies directed against the noncollagenous, C-terminal domain of the α‎-3 chain of type IV collagen (α‎3(IV)NC1). Immunohistology is characteristic, with linear deposition of IgG (sometimes with IgA or IgM) and complement C3 along the GBMs....

Goodpasture's disease: Antiglomerular basement membrane disease

Nephrology ◽  
2004 ◽  
Vol 9 (2) ◽  
pp. 49-51 ◽  
Author(s):  
JONATHAN H ERLICH ◽  
JACOB SEVASTOS ◽  
BRUCE A PUSSELL
Keyword(s):  
Basement Membrane ◽  
Goodpasture's Disease ◽  
Goodpasture’S Disease

Electron microscopic radioautographic studies on the incorporation of 3H proline in the glomerular basement membrane (GBM) in antistreptococcal-cell-membrane (SCM) injected mice

1984 ◽  
Vol 42 ◽  
pp. 188-189
Author(s):  
R.P. Nayyar ◽  
C.F. Lange ◽  
J. L. Borke
Keyword(s):  
Body Weight ◽  
Cell Membrane ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Mesangial Matrix ◽  
Electron Microscopic ◽  
Group A ◽  
Injection Protocol

Streptococcal cell membrane (SCM) antiserum injected mice show a significant thickening of glomerular basement membrane (GBM) and an increase in mesangial matrix within 4 to 24 hours of antiserum administration (1,2,3). This study was undertaken to evaluate the incorporation of 3H proline into glomerular cells and GBM under normal and anti-SCM induced conditions. Mice were administered, intraperitoneally, 0.1 ml of normal or anti-SCM serum followed by a 10 µC/g body weight injection of 3H proline. Details of the preparation of anti-SCM (Group A type 12 streptococcal pyogenes) and other sera and injection protocol have been described elsewhere (2). After 15 minutes of isotope injection a chase of cold proline was given and animal sacrificed at 20 minutes, 1,2,4,8,24 and 48 hours. One of the removed kidneys was processed for immunofluorescence, light and electron microscopic radioautographic studies; second kidney was used for GBM isolation and aminoacid analysis.

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